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ArticlesPeer ReviewedFull Text
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies
Author / Creator:Linse, Sara ; Scheidt, Tom ; Bernfur, Katja ; Vendruscolo, Michele ; Dobson, Christopher M. ; Cohen, Samuel I. A. ; Sileikis, Eimantas ; Lundqvist, Martin ; Qian, Fang ; O’Malley, Tiernan ; Bussiere, Thierry ; Weinreb, Paul H. ; Xu, Catherine K. ; Meisl, Georg ; Devenish, Sean R. A. ; Knowles, Tuomas P. J. ; Hansson, Oskar
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-12, Vol.27 (12), p.1125-1133
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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies
Author / Creator:Sanders, Rogier W ; Derking, Ronald ; Cupo, Albert ; Julien, Jean-Philippe ; Yasmeen, Anila ; de Val, Natalia ; Kim, Helen J ; Blattner, Claudia ; de la Peña, Alba Torrents ; Korzun, Jacob ; Golabek, Michael ; de Los Reyes, Kevin ; Ketas, Thomas J ; van Gils, Marit J ; King, C Richter ; Wilson, Ian A ; Ward, Andrew B ; Klasse, P J ; Moore, John P
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-09, Vol.9 (9), p.e1003618
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Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy
Author / Creator:Javed, Ibrahim ; Peng, Guotao ; Xing, Yanting ; Yu, Tianyu ; Zhao, Mei ; Kakinen, Aleksandr ; Faridi, Ava ; Parish, Clare L. ; Ding, Feng ; Davis, Thomas P. ; Ke, Pu Chun ; Lin, Sijie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-08, Vol.10 (1), p.3780-14, Article 3780
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Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry
Author / Creator:Young, Lydia M. ; Saunders, Janet C. ; Mahood, Rachel A. ; Revill, Charlotte H. ; Foster, Richard J. ; Tu, Ling-Hsien ; Raleigh, Daniel P. ; Radford, Sheena E. ; Ashcroft, Alison E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2015-01, Vol.7 (1), p.73-81
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NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy
Author / Creator:Nakanishi, Hiroshi ; Kawashima, Yoshiyuki ; Kurima, Kiyoto ; Chae, Jae Jin ; Ross, Astin M. ; Pinto-Patarroyo, Gineth ; Patel, Seema K. ; Muskett, Julie A. ; Ratay, Jessica S. ; Chattaraj, Parna ; Park, Yong Hwan ; Grevich, Sriharsha ; Brewer, Carmen C. ; Hoa, Michael ; Kim, H. Jeffrey ; Butman, John A. ; Broderick, Lori ; Hoffman, Hal M. ; Aksentijevich, Ivona ; Kastner, Daniel L. ; Goldbach-Mansky, Raphaela ; Griffith, Andrew J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (37), p.E7766-E7775
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Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo
Author / Creator:Maldini, Colby R. ; Claiborne, Daniel T. ; Okawa, Ken ; Chen, Tao ; Dopkin, Derrick L. ; Shan, Xiaochuan ; Power, Karen A. ; Trifonova, Radiana T. ; Krupp, Katharine ; Phelps, Meredith ; Vrbanac, Vladimir D. ; Tanno, Serah ; Bateson, Timothy ; Leslie, George J. ; Hoxie, James A. ; Boutwell, Christian L. ; Riley, James L. ; Allen, Todd M.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-11, Vol.26 (11), p.1776-1787
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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers
Author / Creator:Ruggeri, Francesco Simone ; Habchi, Johnny ; Chia, Sean ; Horne, Robert I. ; Vendruscolo, Michele ; Knowles, Tuomas P. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.688-9, Article 688
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Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway
Author / Creator:Jian, Min ; Kwan, Jason Shing-Cheong ; Bunting, Myriam ; Ng, Roy Chun-Laam ; Chan, Koon Ho
Publisher:England: BioMed Central
Journal title:Journal of neuroinflammation, 2019-05, Vol.16 (1), p.110-110, Article 110
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Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial
Author / Creator:Stephenson, Kathryn E. ; Julg, Boris ; Tan, C. Sabrina ; Zash, Rebecca ; Walsh, Stephen R. ; Rolle, Charlotte-Paige ; Monczor, Ana N. ; Lupo, Sofia ; Gelderblom, Huub C. ; Ansel, Jessica L. ; Kanjilal, Diane G. ; Maxfield, Lori F. ; Nkolola, Joseph ; Borducchi, Erica N. ; Abbink, Peter ; Liu, Jinyan ; Peter, Lauren ; Chandrashekar, Abishek ; Nityanandam, Ramya ; Lin, Zijin ; Setaro, Alessandra ; Sapiente, Joseph ; Chen, Zhilin ; Sunner, Lisa ; Cassidy, Tyler ; Bennett, Chelsey ; Sato, Alicia ; Mayer, Bryan ; Perelson, Alan S. ; deCamp, Allan ; Priddy, Frances H. ; Wagh, Kshitij ; Giorgi, Elena E. ; Yates, Nicole L. ; Arduino, Roberto C. ; DeJesus, Edwin ; Tomaras, Georgia D. ; Seaman, Michael S. ; Korber, Bette ; Barouch, Dan H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2021-10, Vol.27 (10), p.1718-1724
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Moving the Needle on Alzheimer’s Disease with an Anti-Oligomer Antibody
Author / Creator:Gandy, Sam ; Ehrlich, Michelle E.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-01, Vol.388 (1), p.80-81
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Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model
Author / Creator:Viswanathan, Guru Krishnakumar ; Shwartz, Dana ; Losev, Yelena ; Arad, Elad ; Shemesh, Chen ; Pichinuk, Edward ; Engel, Hamutal ; Raveh, Avi ; Jelinek, Raz ; Cooper, Itzik ; Gosselet, Fabien ; Gazit, Ehud ; Segal, Daniel
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2020-07, Vol.77 (14), p.2795-2813
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ArticlesPeer ReviewedFull Text
Safely targeting cancer stem cells via selective catenin coactivator antagonism
Author / Creator:Lenz, Heinz‐Josef ; Kahn, Michael
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2014-09, Vol.105 (9), p.1087-1092
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ArticlesPeer ReviewedFull Text
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein
Author / Creator:Podracky, Christopher J. ; An, Chihui ; DeSousa, Alexandra ; Dorr, Brent M. ; Walsh, Dominic M. ; Liu, David R.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2021-03, Vol.17 (3), p.317-325
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ArticlesPeer ReviewedFull Text
Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR)
Author / Creator:Ilangovan, Aravindan ; Fletcher, Matthew ; Rampioni, Giordano ; Pustelny, Christian ; Rumbaugh, Kendra ; Heeb, Stephan ; Cámara, Miguel ; Truman, Alex ; Chhabra, Siri Ram ; Emsley, Jonas ; Williams, Paul
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2013-07, Vol.9 (7), p.e1003508
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ArticlesPeer ReviewedFull Text
The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer
Author / Creator:Yan, Yuqian ; Ma, Jian ; Wang, Dejie ; Lin, Dong ; Pang, Xiaodong ; Wang, Shangqian ; Zhao, Yu ; Shi, Lei ; Xue, Hui ; Pan, Yunqian ; Zhang, Jun ; Wahlestedt, Claes ; Giles, Francis J ; Chen, Yu ; Gleave, Martin E ; Collins, Collin C ; Ye, Dingwei ; Wang, Yuzhuo ; Huang, Haojie
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2019-11, Vol.11 (11), p.e10659-n/a
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ArticlesPeer ReviewedFull Text
Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis
Author / Creator:Zhang, Can ; Griciuc, Ana ; Hudry, Eloise ; Wan, Yu ; Quinti, Luisa ; Ward, Joseph ; Forte, Angela M. ; Shen, Xunuo ; Ran, ChongZhao ; Elmaleh, David R. ; Tanzi, Rudolph E.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-01, Vol.8 (1), p.1144-9, Article 1144
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ArticlesPeer ReviewedFull Text
Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model
Author / Creator:Lin, Lin ; Li, Cheng ; Zhang, Deyi ; Yuan, Mingxiang ; Chen, Chun-hai ; Li, Maoquan
Publisher:New York: Springer US
Journal title:Neurochemical research, 2020-05, Vol.45 (5), p.1130-1141
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Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia
Author / Creator:Gang, E J ; Hsieh, Y-T ; Pham, J ; Zhao, Y ; Nguyen, C ; Huantes, S ; Park, E ; Naing, K ; Klemm, L ; Swaminathan, S ; Conway, E M ; Pelus, L M ; Crispino, J ; Mullighan, C G ; McMillan, M ; Müschen, M ; Kahn, M ; Kim, Y-M
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-04, Vol.33 (17), p.2169-2178
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ArticlesPeer ReviewedFull Text
Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit
Author / Creator:Diomede, Luisa ; Rigacci, Stefania ; Romeo, Margherita ; Stefani, Massimo ; Salmona, Mario
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e58893
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Optimal control strategies for inhibition of protein aggregation
Author / Creator:Michaels, Thomas C. T. ; Weber, Christoph A. ; Mahadevan, L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (29), p.14593-14598
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Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies

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A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies

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Inhibition of amyloid beta toxicity in zebrafish with a chaperone-gold nanoparticle dual strategy

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Screening and classifying small-molecule inhibitors of amyloid formation using ion mobility spectrometry–mass spectrometry

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NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy

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Dual CD4-based CAR T cells with distinct costimulatory domains mitigate HIV pathogenesis in vivo

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Infrared nanospectroscopy reveals the molecular interaction fingerprint of an aggregation inhibitor with single Aβ42 oligomers

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Adiponectin suppresses amyloid-β oligomer (AβO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-κB signaling pathway

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Safety, pharmacokinetics and antiviral activity of PGT121, a broadly neutralizing monoclonal antibody against HIV-1: a randomized, placebo-controlled, phase 1 clinical trial

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Moving the Needle on Alzheimer’s Disease with an Anti-Oligomer Antibody

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Purpurin modulates Tau-derived VQIVYK fibrillization and ameliorates Alzheimer’s disease-like symptoms in animal model

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Safely targeting cancer stem cells via selective catenin coactivator antagonism

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Laboratory evolution of a sortase enzyme that modifies amyloid-β protein

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Structural basis for native agonist and synthetic inhibitor recognition by the Pseudomonas aeruginosa quorum sensing regulator PqsR (MvfR)

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The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

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Cromolyn Reduces Levels of the Alzheimer’s Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis

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Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer’s Disease Mouse Model

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Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

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Oleuropein aglycone protects transgenic C. elegans strains expressing Aβ42 by reducing plaque load and motor deficit

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Optimal control strategies for inhibition of protein aggregation

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