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77 results for Receptors,+Opioid,+mu+-+chemistry

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ArticlesPeer ReviewedFull Text
Structural insights into µ-opioid receptor activation
Author / Creator:Huang, Weijiao ; Manglik, Aashish ; Venkatakrishnan, A. J. ; Laeremans, Toon ; Feinberg, Evan N. ; Sanborn, Adrian L. ; Kato, Hideaki E. ; Livingston, Kathryn E. ; Thorsen, Thor S. ; Kling, Ralf C. ; Granier, Sébastien ; Gmeiner, Peter ; Husbands, Stephen M. ; Traynor, John R. ; Weis, William I. ; Steyaert, Jan ; Dror, Ron O. ; Kobilka, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-08, Vol.524 (7565), p.315-321
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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
Author / Creator:Manglik, Aashish ; Kruse, Andrew C. ; Kobilka, Tong Sun ; Thian, Foon Sun ; Mathiesen, Jesper M. ; Sunahara, Roger K. ; Pardo, Leonardo ; Weis, William I. ; Kobilka, Brian K. ; Granier, Sébastien
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-05, Vol.485 (7398), p.321-326
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Structure-based design of bitopic ligands for the µ-opioid receptor
Author / Creator:Faouzi, Abdelfattah ; Wang, Haoqing ; Zaidi, Saheem A. ; DiBerto, Jeffrey F. ; Che, Tao ; Qu, Qianhui ; Robertson, Michael J. ; Madasu, Manish K. ; El Daibani, Amal ; Varga, Balazs R. ; Zhang, Tiffany ; Ruiz, Claudia ; Liu, Shan ; Xu, Jin ; Appourchaux, Kevin ; Slocum, Samuel T. ; Eans, Shainnel O. ; Cameron, Michael D. ; Al-Hasani, Ream ; Pan, Ying Xian ; Roth, Bryan L. ; McLaughlin, Jay P. ; Skiniotis, Georgios ; Katritch, Vsevolod ; Kobilka, Brian K. ; Majumdar, Susruta
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-01, Vol.613 (7945), p.767-774
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Propagation of conformational changes during μ-opioid receptor activation
Author / Creator:Sounier, Rémy ; Mas, Camille ; Steyaert, Jan ; Laeremans, Toon ; Manglik, Aashish ; Huang, Weijiao ; Kobilka, Brian K. ; Déméné, Héléne ; Granier, Sébastien
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-08, Vol.524 (7565), p.375-378
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A nontoxic pain killer designed by modeling of pathological receptor conformations
Author / Creator:Spahn, V. ; Del Vecchio, G. ; Labuz, D. ; Rodriguez-Gaztelumendi, A. ; Massaly, N. ; Temp, J. ; Durmaz, V. ; Sabri, P. ; Reidelbach, M. ; Machelska, H. ; Weber, M. ; Stein, C.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6328), p.966-969
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How μ-opioid receptor recognizes fentanyl
Author / Creator:Vo, Quynh N. ; Mahinthichaichan, Paween ; Shen, Jana ; Ellis, Christopher R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-02, Vol.12 (1), p.984-11, Article 984
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Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor
Author / Creator:Mafi, Amirhossein ; Kim, Soo-Kyung ; Goddard, William A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (28), p.16346-16355
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Predicting opioid receptor binding affinity of pharmacologically unclassified designer substances using molecular docking
Author / Creator:Ellis, Christopher R ; Kruhlak, Naomi L ; Kim, Marlene T ; Hawkins, Edward G ; Stavitskaya, Lidiya
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-05, Vol.13 (5), p.e0197734-e0197734
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Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator
Author / Creator:Kaneko, Shun ; Imai, Shunsuke ; Uchikubo-Kamo, Tomomi ; Hisano, Tamao ; Asao, Nobuaki ; Shirouzu, Mikako ; Shimada, Ichio
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.3544-3544, Article 3544
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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site
Author / Creator:Uprety, Rajendra ; Che, Tao ; Zaidi, Saheem A ; Grinnell, Steven G ; Varga, Balázs R ; Faouzi, Abdelfattah ; Slocum, Samuel T ; Allaoa, Abdullah ; Varadi, András ; Nelson, Melissa ; Bernhard, Sarah M ; Kulko, Elizaveta ; Le Rouzic, Valerie ; Eans, Shainnel O ; Simons, Chloe A ; Hunkele, Amanda ; Subrath, Joan ; Pan, Ying Xian ; Javitch, Jonathan A ; McLaughlin, Jay P ; Roth, Bryan L ; Pasternak, Gavril W ; Katritch, Vsevolod ; Majumdar, Susruta
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-02, Vol.10
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Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model
Author / Creator:Marino, Kristen A ; Prada-Gracia, Diego ; Provasi, Davide ; Filizola, Marta
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2016-12, Vol.12 (12), p.e1005240-e1005240
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A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor
Author / Creator:Dekan, Zoltan ; Sianati, Setareh ; Yousuf, Arsalan ; Sutcliffe, Katy J. ; Gillis, Alexander ; Mallet, Christophe ; Singh, Paramjit ; Jin, Aihua H. ; Wang, Anna M. ; Mohammadi, Sarasa A. ; Stewart, Michael ; Ratnayake, Ranjala ; Fontaine, Frank ; Lacey, Ernest ; Piggott, Andrew M. ; Du, Yan P. ; Canals, Meritxell ; Sessions, Richard B. ; Kelly, Eamonn ; Capon, Robert J. ; Alewood, Paul F. ; Christ, MacDonald J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (44), p.22353-22358
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Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons
Author / Creator:Halikere, Apoorva ; Popova, Dina ; Scarnati, Matthew S. ; Hamod, Aula ; Swerdel, Mavis R. ; Moore, Jennifer C. ; Tischfield, Jay A. ; Hart, Ronald P. ; Pang, Zhiping P.
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2020-07, Vol.25 (7), p.1406-1419
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Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis
Author / Creator:Hu, Xiaohu ; Wang, Yibo ; Hunkele, Amanda ; Provasi, Davide ; Pasternak, Gavril W ; Filizola, Marta
Publisher:United States: Public Library of Science
Journal title:PLoS computational biology, 2019-01, Vol.15 (1), p.e1006689-e1006689
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Kappa but not delta or mu opioid receptors form homodimers at low membrane densities
Author / Creator:Cechova, Kristina ; Lan, Chenyang ; Macik, Matus ; Barthes, Nicolas P. F. ; Jung, Manfred ; Ulbrich, Maximilian H.
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2021-12, Vol.78 (23), p.7557-7568
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Exploring the activation pathway and G i -coupling specificity of the μ-opioid receptor
Author / Creator:Mondal, Dibyendu ; Kolev, Vesselin ; Warshel, Arieh
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-10, Vol.117 (42), p.26218-26225
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μ Opioid receptor: novel antagonists and structural modeling
Author / Creator:Kaserer, Teresa ; Lantero, Aquilino ; Schmidhammer, Helmut ; Spetea, Mariana ; Schuster, Daniela
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-02, Vol.6 (1), p.21548, Article 21548
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Structural basis of μ-opioid receptor targeting by a nanobody antagonist
Author / Creator:Yu, Jun ; Kumar, Amit ; Zhang, Xuefeng ; Martin, Charlotte ; Van holsbeeck, Kevin ; Raia, Pierre ; Koehl, Antoine ; Laeremans, Toon ; Steyaert, Jan ; Manglik, Aashish ; Ballet, Steven ; Boland, Andreas ; Stoeber, Miriam
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-10, Vol.15 (1), p.8687-15, Article 8687
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Molecular insights into the interaction of hemorphin and its targets
Author / Creator:Ali, Amanat ; Baby, Bincy ; Soman, Soja Saghar ; Vijayan, Ranjit
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-10, Vol.9 (1), p.14747-16, Article 14747
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Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects
Author / Creator:Majumdar, Susruta ; Grinnell, Steven ; Le Rouzic, Valerie ; Burgman, Maxim ; Polikar, Lisa ; Ansonoff, Michael ; Pintar, John ; Pan, Ying-Xian ; Pasternak, Gavril W
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19778-19783
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Structural insights into µ-opioid receptor activation

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Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

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Structure-based design of bitopic ligands for the µ-opioid receptor

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Propagation of conformational changes during μ-opioid receptor activation

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A nontoxic pain killer designed by modeling of pathological receptor conformations

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How μ-opioid receptor recognizes fentanyl

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Mechanism of β-arrestin recruitment by the μ-opioid G protein-coupled receptor

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Predicting opioid receptor binding affinity of pharmacologically unclassified designer substances using molecular docking

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Structural and dynamic insights into the activation of the μ-opioid receptor by an allosteric modulator

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Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

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Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model

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A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

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Addiction associated N40D mu-opioid receptor variant modulates synaptic function in human neurons

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Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis

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Kappa but not delta or mu opioid receptors form homodimers at low membrane densities

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Exploring the activation pathway and G i -coupling specificity of the μ-opioid receptor

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μ Opioid receptor: novel antagonists and structural modeling

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Structural basis of μ-opioid receptor targeting by a nanobody antagonist

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Molecular insights into the interaction of hemorphin and its targets

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Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects

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