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469 results for Receptors,+Opioid,+mu+-+genetics

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Structure-based discovery of opioid analgesics with reduced side effects
Author / Creator:Manglik, Aashish ; Lin, Henry ; Aryal, Dipendra K. ; McCorvy, John D. ; Dengler, Daniela ; Corder, Gregory ; Levit, Anat ; Kling, Ralf C. ; Bernat, Viachaslau ; Hübner, Harald ; Huang, Xi-Ping ; Sassano, Maria F. ; Giguère, Patrick M. ; Löber, Stefan ; Da Duan ; Scherrer, Grégory ; Kobilka, Brian K. ; Gmeiner, Peter ; Roth, Bryan L. ; Shoichet, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-09, Vol.537 (7619), p.185-190
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Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
Author / Creator:Corder, Gregory ; Tawfik, Vivianne L ; Wang, Dong ; Sypek, Elizabeth I ; Low, Sarah A ; Dickinson, Jasmine R ; Sotoudeh, Chaudy ; Clark, J David ; Barres, Ben A ; Bohlen, Christopher J ; Scherrer, Grégory
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-02, Vol.23 (2), p.164-173
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Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects
Author / Creator:Kliewer, A. ; Schmiedel, F. ; Sianati, S. ; Bailey, A. ; Bateman, J. T. ; Levitt, E. S. ; Williams, J. T. ; Christie, M. J. ; Schulz, S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.367-11, Article 367
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Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice
Author / Creator:He, Li ; Gooding, Sarah W ; Lewis, Elinor ; Felth, Lindsey C ; Gaur, Anirudh ; Whistler, Jennifer L
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2021-12, Vol.46 (13), p.2241-2249
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A nontoxic pain killer designed by modeling of pathological receptor conformations
Author / Creator:Spahn, V. ; Del Vecchio, G. ; Labuz, D. ; Rodriguez-Gaztelumendi, A. ; Massaly, N. ; Temp, J. ; Durmaz, V. ; Sabri, P. ; Reidelbach, M. ; Machelska, H. ; Weber, M. ; Stein, C.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6328), p.966-969
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Neural basis of opioid-induced respiratory depression and its rescue
Author / Creator:Liu, Shijia ; Kim, Dong-Il ; Oh, Tae Gyu ; Pao, Gerald M. ; Kim, Jong-Hyun ; Palmiter, Richard D. ; Banghart, Matthew R. ; Lee, Kuo-Fen ; Evans, Ronald M. ; Han, Sung
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (23), p.1-9
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Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors
Author / Creator:Möller, Jan ; Isbilir, Ali ; Sungkaworn, Titiwat ; Osberg, Brendan ; Karathanasis, Christos ; Sunkara, Vikram ; Grushevskyi, Eugene O. ; Bock, Andreas ; Annibale, Paolo ; Heilemann, Mike ; Schütte, Christof ; Lohse, Martin J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2020-09, Vol.16 (9), p.946-954
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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
Author / Creator:Liu, Yuchen ; Li, Dameng ; Liu, Zhengya ; Zhou, Yu ; Chu, Danping ; Li, Xihan ; Jiang, Xiaohong ; Hou, Dongxia ; Chen, Xi ; Chen, Yuda ; Yang, Zhanzhao ; Jin, Ling ; Jiang, Waner ; Tian, Chenfei ; Zhou, Geyu ; Zen, Ke ; Zhang, Junfeng ; Zhang, Yujing ; Li, Jing ; Zhang, Chen-Yu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2015-12, Vol.5 (1), p.17543-17543, Article 17543
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Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity
Author / Creator:Robinson, Mike J F ; Burghardt, Paul R ; Patterson, Christa M ; Nobile, Cameron W ; Akil, Huda ; Watson, Stanley J ; Berridge, Kent C ; Ferrario, Carrie R
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2015-08, Vol.40 (9), p.2113-2123
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Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures
Author / Creator:Peciña, Marta ; Love, Tiffany ; Stohler, Christian S ; Goldman, David ; Zubieta, Jon-Kar
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2015-03, Vol.40 (4), p.957-965
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Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors
Author / Creator:Falcon, Edgardo ; Browne, Caroline A ; Leon, Rosa M ; Fleites, Vanessa C ; Sweeney, Rachel ; Kirby, Lynn G ; Lucki, Irwin
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2016-08, Vol.41 (9), p.2344-2351
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Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
Author / Creator:Gaddis, Nathan ; Mathur, Ravi ; Marks, Jesse ; Zhou, Linran ; Quach, Bryan ; Waldrop, Alex ; Levran, Orna ; Agrawal, Arpana ; Randesi, Matthew ; Adelson, Miriam ; Jeffries, Paul W. ; Martin, Nicholas G. ; Degenhardt, Louisa ; Montgomery, Grant W. ; Wetherill, Leah ; Lai, Dongbing ; Bucholz, Kathleen ; Foroud, Tatiana ; Porjesz, Bernice ; Runarsdottir, Valgerdur ; Tyrfingsson, Thorarinn ; Einarsson, Gudmundur ; Gudbjartsson, Daniel F. ; Webb, Bradley Todd ; Crist, Richard C. ; Kranzler, Henry R. ; Sherva, Richard ; Zhou, Hang ; Hulse, Gary ; Wildenauer, Dieter ; Kelty, Erin ; Attia, John ; Holliday, Elizabeth G. ; McEvoy, Mark ; Scott, Rodney J. ; Schwab, Sibylle G. ; Maher, Brion S. ; Gruza, Richard ; Kreek, Mary Jeanne ; Nelson, Elliot C. ; Thorgeirsson, Thorgeir ; Stefansson, Kari ; Berrettini, Wade H. ; Gelernter, Joel ; Edenberg, Howard J. ; Bierut, Laura ; Hancock, Dana B. ; Johnson, Eric Otto
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-10, Vol.12 (1), p.16873-16, Article 16873
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The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor
Author / Creator:Samuels, Benjamin Adam ; Nautiyal, Katherine M ; Kruegel, Andrew C ; Levinstein, Marjorie R ; Magalong, Valerie M ; Gassaway, Madalee M ; Grinnell, Steven G ; Han, Jaena ; Ansonoff, Michael A ; Pintar, John E ; Javitch, Jonathan A ; Sames, Dalibor ; Hen, René
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2017-09, Vol.42 (10), p.2052-2063
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Mu opioid receptors in the medial habenula contribute to naloxone aversion
Author / Creator:Boulos, L J ; Ben Hamida, S ; Bailly, J ; Maitra, M ; Ehrlich, A T ; Gavériaux-Ruff, C ; Darcq, E ; Kieffer, B L
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology, 2020-01, Vol.45 (2), p.247-255
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μ-opioid receptor system mediates reward processing in humans
Author / Creator:Nummenmaa, Lauri ; Saanijoki, Tiina ; Tuominen, Lauri ; Hirvonen, Jussi ; Tuulari, Jetro J. ; Nuutila, Pirjo ; Kalliokoski, Kari
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-04, Vol.9 (1), p.1500-7, Article 1500
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The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer
Author / Creator:Lennon, Frances E ; Mirzapoiazova, Tamara ; Mambetsariev, Bolot ; Poroyko, Valeriy A ; Salgia, Ravi ; Moss, Jonathan ; Singleton, Patrick A
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-03, Vol.9 (3), p.e91577
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Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids
Author / Creator:Cai, Ning-Sheng ; Quiroz, César ; Bonaventura, Jordi ; Bonifazi, Alessandro ; Cole, Thomas O ; Purks, Julia ; Billing, Amy S ; Massey, Ebonie ; Wagner, Michael ; Wish, Eric D ; Guitart, Xavier ; Rea, William ; Lam, Sherry ; Moreno, Estefanía ; Casadó-Anguera, Verònica ; Greenblatt, Aaron D ; Jacobson, Arthur E ; Rice, Kenner C ; Casadó, Vicent ; Newman, Amy H ; Winkelman, John W ; Michaelides, Michael ; Weintraub, Eric ; Volkow, Nora D ; Belcher, Annabelle M ; Ferré, Sergi
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-07, Vol.129 (7), p.2730-2744
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Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection
Author / Creator:Way, Baldwin M ; Taylor, Shelley E ; Eisenberger, Naomi I
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-09, Vol.106 (35), p.15079-15084
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Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network
Author / Creator:Baertsch, Nathan A ; Bush, Nicholas E ; Burgraff, Nicholas J ; Ramirez, Jan-Marino
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-08, Vol.10
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Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome
Author / Creator:Mechling, Anna E. ; Arefin, Tanzil ; Lee, Hsu-Lei ; Bienert, Thomas ; Reisert, Marco ; Hamida, Sami Ben ; Darcq, Emmanuel ; Ehrlich, Aliza ; Gaveriaux-Ruff, Claire ; Parent, Maxime J. ; Rosa-Neto, Pedro ; Hennig, Jürgen ; von Elverfeldt, Dominik ; Kieffer, Brigitte Lina ; Harsan, Laura-Adela
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-10, Vol.113 (41), p.11603-11608
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Structure-based discovery of opioid analgesics with reduced side effects

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Loss of μ opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia

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Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

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Pharmacological and genetic manipulations at the µ-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice

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A nontoxic pain killer designed by modeling of pathological receptor conformations

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Neural basis of opioid-induced respiratory depression and its rescue

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Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors

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Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse

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Individual Differences in Cue-Induced Motivation and Striatal Systems in Rats Susceptible to Diet-Induced Obesity

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Effects of the Mu opioid receptor polymorphism (OPRM1 A118G) on pain regulation, placebo effects and associated personality trait measures

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Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors

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Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond

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The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

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Mu opioid receptors in the medial habenula contribute to naloxone aversion

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μ-opioid receptor system mediates reward processing in humans

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The Mu opioid receptor promotes opioid and growth factor-induced proliferation, migration and Epithelial Mesenchymal Transition (EMT) in human lung cancer

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Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids

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Variation in the μ-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

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Dual mechanisms of opioid-induced respiratory depression in the inspiratory rhythm-generating network

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Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome

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