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ArticlesPeer ReviewedFull Text
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes
Author / Creator:Guma, Monica ; Dadpey, Benyamin ; Coras, Roxana ; Mikuls, Ted R. ; Hamilton, Bartlett ; Quehenberger, Oswald ; Thorisdottir, Hilda ; Bittleman, David ; Lauro, Kimberly ; Reilly, Shannon M. ; Liu-Bryan, Ru ; Terkeltaub, Robert
Publisher:England: BioMed Central Ltd
Journal title:Arthritis research & therapy, 2022-07, Vol.24 (1), p.175-13, Article 175
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ArticlesPeer ReviewedFull Text
Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
Author / Creator:Mowers, Jonathan ; Uhm, Maeran ; Reilly, Shannon M ; Simon, Joshua ; Leto, Dara ; Chiang, Shian-Huey ; Chang, Louise ; Saltiel, Alan R
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2013-12, Vol.2, p.e01119-e01119
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RalA controls glucose homeostasis by regulating glucose uptake in brown fat
Author / Creator:Skorobogatko, Yuliya ; Dragan, Morgan ; Cordon, Claudia ; Reilly, Shannon M. ; Hung, Chao-Wei ; Xia, Wenmin ; Zhao, Peng ; Wallace, Martina ; Lackey, Denise E. ; Chen, Xiao-Wei ; 陈晓伟 ; Osborn, Olivia ; Bogner-Strauss, Juliane G. ; Theodorescu, Dan ; Metallo, Christian M. ; Olefsky, Jerrold M. ; Saltiel, Alan R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (30), p.7819-7824
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Adapting to obesity with adipose tissue inflammation
Author / Creator:Reilly, Shannon M. ; Saltiel, Alan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2017-11, Vol.13 (11), p.633-643
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ArticlesPeer ReviewedFull Text
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Author / Creator:Fang, Sungsoon ; Suh, Jae Myoung ; Reilly, Shannon M ; Yu, Elizabeth ; Osborn, Olivia ; Lackey, Denise ; Yoshihara, Eiji ; Perino, Alessia ; Jacinto, Sandra ; Lukasheva, Yelizaveta ; Atkins, Annette R ; Khvat, Alexander ; Schnabl, Bernd ; Yu, Ruth T ; Brenner, David A ; Coulter, Sally ; Liddle, Christopher ; Schoonjans, Kristina ; Olefsky, Jerrold M ; Saltiel, Alan R ; Downes, Michael ; Evans, Ronald M
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-02, Vol.21 (2), p.159-165
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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes
Author / Creator:Keinan, Omer ; Valentine, Joseph M. ; Xiao, Haopeng ; Mahata, Sushil K. ; Reilly, Shannon M. ; Abu-Odeh, Mohammad ; Deluca, Julia H. ; Dadpey, Benyamin ; Cho, Leslie ; Pan, Austin ; Yu, Ruth T. ; Dai, Yang ; Liddle, Christopher ; Downes, Michael ; Evans, Ronald M. ; Lusis, Aldons J. ; Laakso, Markku ; Chouchani, Edward T. ; Rydén, Mikael ; Saltiel, Alan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-11, Vol.599 (7884), p.296-301
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YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity
Author / Creator:Wang, Lirui ; Mazagova, Magdalena ; Pan, Chuyue ; Yang, Song ; Brandl, Katharina ; Liu, Jun ; Reilly, Shannon M. ; Wang, Yanhan ; Miao, Zhaorui ; Loomba, Rohit ; Lu, Na ; Guo, Qinglong ; Liu, Jihua ; Yu, Ruth T. ; Downes, Michael ; Evans, Ronald M. ; Brenner, David A. ; Saltiel, Alan R. ; Beutler, Bruce ; Schnabl, Bernd
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (30), p.15184-15193
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A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis
Author / Creator:Reilly, Shannon M. ; Ahmadian, Maryam ; Zamarron, Brian F. ; Chang, Louise ; Uhm, Maeran ; Poirier, BreAnne ; Peng, Xiaoling ; Krause, Danielle M. ; Korytnaya, Evgenia ; Neidert, Adam ; Liddle, Christopher ; Yu, Ruth T. ; Lumeng, Carey N. ; Oral, Elif A. ; Downes, Michael ; Evans, Ronald M. ; Saltiel, Alan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-01, Vol.6 (1), p.6047-6047, Article 6047
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FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition
Author / Creator:Reilly, Shannon M. ; Abu-Odeh, Mohammad ; Ameka, Magdalene ; DeLuca, Julia H. ; Naber, Meghan C. ; Dadpey, Benyamin ; Ebadat, Nima ; Gomez, Andrew V. ; Peng, Xiaoling ; Poirier, BreAnne ; Walk, Elyse ; Potthoff, Matthew J. ; Saltiel, Alan R.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2021-05, Vol.131 (10), p.1-15
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ArticlesPeer ReviewedFull Text
Countering inflammatory signals in obesity
Author / Creator:Reilly, Shannon M ; Saltiel, Alan R
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2014-05, Vol.15 (5), p.410-411
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ArticlesPeer ReviewedFull Text
Obesity: A complex role for adipose tissue macrophages
Author / Creator:Reilly, Shannon M ; Saltiel, Alan R
Publisher:England: Nature Publishing Group
Journal title:Nature reviews. Endocrinology, 2014-04, Vol.10 (4), p.193-194
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ArticlesPeer ReviewedFull Text
A complex role for adipose tissue macrophages
Author / Creator:Reilly, Shannon M. ; Saltiel, Alan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2014-04, Vol.10 (4), p.193-194
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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
Author / Creator:Reilly, Shannon M ; Chiang, Shian-Huey ; Decker, Stuart J ; Chang, Louise ; Uhm, Maeran ; Larsen, Martha J ; Rubin, John R ; Mowers, Jonathan ; White, Nicole M ; Hochberg, Irit ; Downes, Michael ; Yu, Ruth T ; Liddle, Christopher ; Evans, Ronald M ; Oh, Dayoung ; Li, Pingping ; Olefsky, Jerrold M ; Saltiel, Alan R
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2013-03, Vol.19 (3), p.313-321
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Countering inflammatory signals in obesity: although it is generally considered a proinflammatory cytokine, interleukin 6 has anti-inflammatory effects in macrophages by sensitizing them to IL-4 throu...
Author / Creator:Reilly, Shannon M ; Saltiel, Alan R
Publisher:Nature Publishing Group
Journal title:Nature immunology, 2014-05, Vol.15 (5), p.410
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Alternative Complement Pathway Regulates Thermogenic Fat Function via Adipsin and Adipocyte-derived C3aR1 in a Sex-dependent Fashion
Author / Creator:Ma, Lunkun ; Gilani, Ankit ; Rubio-Navarro, Alfonso ; Cortada, Eric ; Ang, Li ; Reilly, Shannon M ; Tang, Liling ; Lo, James C
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-12
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FGF21 is required for the metabolic benefits of IKK[epsilon]/ TBK1 inhibition
Author / Creator:Reilly, Shannon M ; Abu-Odeh, Mohammad ; Ameka, Magdalene ; DeLuca, Julia H ; Naber, Meghan C ; Dadpey, Benyamin ; Ebadat, Nima ; Gomez, Andrew V ; Peng, Xiaoling ; Poirier, BreAnne ; Walk, Elyse ; Potthoff, Matthew J ; Saltiel, Alan R
Publisher:American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2021-05, Vol.131 (10)
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An inhibitor of the protein kinases TBK1 and IKK-[varepsilon] improves obesity-related metabolic dysfunctions in mice
Author / Creator:Reilly, Shannon M ; Chiang, Shian-huey ; Decker, Stuart J ; Chang, Louise ; Uhm, Maeran ; Larsen, Martha J ; Rubin, John R ; Mowers, Jonathan ; White, Nicole M ; Hochberg, Irit ; Downes, Michael ; Yu, Ruth T ; Liddle, Christopher ; Evans, Ronald M ; Oh, Dayoung ; Li, Pingping ; Olefsky, Jerrold M ; Saltiel, Alan R
Publisher:New York: Nature Publishing Group
Journal title:Nature medicine, 2013-03, Vol.19 (3), p.313
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An inhibitor of the protein kinases TBK1 and IKKζ improves obesity-related metabolic dysfunctions in mice
Author / Creator:Reilly, Shannon M ; Chiang, Shian-Huey ; Decker, Stuart J ; Chang, Louise ; Uhm, Maeran ; Larsen, Martha J ; Rubin, John R ; Mowers, Jonathan ; White, Nicole M ; Hochberg, Irit ; Downes, Michael ; Yu, Ruth T ; Liddle, Christopher ; Evans, Ronald M ; Oh, Dayoung ; Li, Pingping ; Olefsky, Jerrold M ; Saltiel, Alan R
Publisher:Nature Publishing Group
Journal title:Nature medicine, 2013-03, Vol.19 (3), p.313
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An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions
Author / Creator:Reilly, Shannon M. ; Chiang, Shian-Huey ; Decker, Stuart J. ; Chang, Louise ; Uhm, Maeran ; Larsen, Martha J. ; Rubin, John R. ; Mowers, Jonathan ; White, Nicole M. ; Hochberg, Irit ; Downes, Michael ; Yu, Ruth ; Liddle, Christopher ; Evans, Ronald M. ; Oh, Dayoung ; Li, Pingping ; Olefsky, Jerrold M. ; Saltiel, Alan R.
Journal title:Nature medicine, 2013-02, Vol.19 (3), p.313-321
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Adipocyte-secreted IL-6 sensitizes macrophages to IL-4 signaling
Author / Creator:Luan, Danny A ; Benyamin Dadpey ; Zaid, Jessica ; Bridge-Comer, Pania E ; Deluca, Julia H ; Xia, Wenmin ; Castle, Joshua ; Reilly, Shannon Marie
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2022-10
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Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes

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Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

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RalA controls glucose homeostasis by regulating glucose uptake in brown fat

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Adapting to obesity with adipose tissue inflammation

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Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

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Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes

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YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity

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A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis

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FGF21 is required for the metabolic benefits of IKKε/TBK1 inhibition

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Countering inflammatory signals in obesity

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Obesity: A complex role for adipose tissue macrophages

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A complex role for adipose tissue macrophages

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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

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Countering inflammatory signals in obesity: although it is generally considered a proinflammatory cytokine, interleukin 6 has anti-inflammatory effects in macrophages by sensitizing them to IL-4 throu...

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Alternative Complement Pathway Regulates Thermogenic Fat Function via Adipsin and Adipocyte-derived C3aR1 in a Sex-dependent Fashion

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FGF21 is required for the metabolic benefits of IKK[epsilon]/ TBK1 inhibition

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An inhibitor of the protein kinases TBK1 and IKK-[varepsilon] improves obesity-related metabolic dysfunctions in mice

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An inhibitor of the protein kinases TBK1 and IKKζ improves obesity-related metabolic dysfunctions in mice

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An inhibitor of the protein kinases TBK1/IKKε improves obesity-related metabolic dysfunctions

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Adipocyte-secreted IL-6 sensitizes macrophages to IL-4 signaling

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