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Reference EntriesFull Text
Shokat, Kevan M
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: SAR-SOK, 2022, p.10444-10444
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Shokat, Kevan M
Journal title:American Men & Women of Science : A Biographical Directory of Today’s Leaders in Physical, Biological and Related Sciences: SAV-SOP, 2021, p.10413-10413
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ArticlesPeer ReviewedFull Text
Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design
Author / Creator:Ostrem, Jonathan M. L. ; Shokat, Kevan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2016-11, Vol.15 (11), p.771-785
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ArticlesPeer ReviewedFull Text
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Author / Creator:Ostrem, Jonathan M. ; Peters, Ulf ; Sos, Martin L. ; Wells, James A. ; Shokat, Kevan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-11, Vol.503 (7477), p.548-551
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ArticlesPeer ReviewedFull Text
Evolutionarily divergent mTOR remodels translatome for tissue regeneration
Author / Creator:Zhulyn, Olena ; Rosenblatt, Hannah D. ; Shokat, Leila ; Dai, Shizhong ; Kuzuoglu-Öztürk, Duygu ; Zhang, Zijian ; Ruggero, Davide ; Shokat, Kevan M. ; Barna, Maria
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-08, Vol.620 (7972), p.163-171
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ArticlesPeer ReviewedFull Text
Chemical genetic discovery of targets and anti-targets for cancer polypharmacology
Author / Creator:Dar, Arvin C. ; Das, Tirtha K. ; Shokat, Kevan M. ; Cagan, Ross L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-06, Vol.486 (7401), p.80-84
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ArticlesPeer ReviewedFull Text
Site-specific incorporation of phosphotyrosine using an expanded genetic code
Author / Creator:Hoppmann, Christian ; Wong, Allison ; Yang, Bing ; Li, Shuwei ; Hunter, Tony ; Shokat, Kevan M ; Wang, Lei
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2017-08, Vol.13 (8), p.842-844
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ArticlesPeer ReviewedFull Text
Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II
Author / Creator:Larochelle, Stéphane ; Amat, Ramon ; Glover-Cutter, Kira ; Sansó, Miriam ; Zhang, Chao ; Allen, Jasmina J ; Shokat, Kevan M ; Bentley, David L ; Fisher, Robert P
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2012-11, Vol.19 (11), p.1108-1115
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ArticlesPeer ReviewedFull Text
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
Author / Creator:Pourdehnad, Michael ; Truitt, Morgan L. ; Siddiqi, Imran N. ; Ducker, Gregory S. ; Shokat, Kevan M. ; Ruggero, Davide
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.11988-11993
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ArticlesPeer ReviewedFull Text
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
Author / Creator:Feldman, Morris E ; Apsel, Beth ; Uotila, Aino ; Loewith, Robbie ; Knight, Zachary A ; Ruggero, Davide ; Shokat, Kevan M
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2009-02, Vol.7 (2), p.e1000038-e1000038
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ArticlesPeer ReviewedFull Text
IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response
Author / Creator:Lin, Jonathan H ; Li, Han ; Yasumura, Douglas ; Cohen, Hannah R ; Zhang, Chao ; Panning, Barbara ; Shokat, Kevan M ; LaVail, Matthew M ; Walter, Peter
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2007-11, Vol.318 (5852), p.944-949
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ArticlesPeer ReviewedFull Text
sharp T-cell antigen receptor signaling threshold for T-cell proliferation
Author / Creator:Au-Yeung, Byron B. ; Zikherman, Julie ; Mueller, James L. ; Ashouri, Judith F. ; Matloubian, Mehrdad ; Cheng, Debra A. ; Chen, Yiling ; Shokat, Kevan M. ; Weiss, Arthur
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (35), p.E3679-E3688
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ArticlesPeer ReviewedFull Text
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
Author / Creator:Sauer, Stephan ; Bruno, Ludovica ; Hertweck, Arnulf ; Finlay, David ; Leleu, Marion ; Spivakov, Mikhail ; Knight, Zachary A ; Cobb, Bradley S ; Cantrell, Doreen ; O'Connor, Eric ; Shokat, Kevan M ; Fisher, Amanda G ; Merkenschlager, Matthias
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-06, Vol.105 (22), p.7797-7802
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ArticlesPeer ReviewedFull Text
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
Author / Creator:Sergina, Natalia V. ; Rausch, Megan ; Wang, Donghui ; Blair, Jimmy ; Hann, Byron ; Shokat, Kevan M. ; Moasser, Mark M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature, 2007-01, Vol.445 (7126), p.437-441
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ArticlesPeer ReviewedFull Text
Recognizing and exploiting differences between RNAi and small-molecule inhibitors
Author / Creator:Weiss, William A ; Taylor, Stephen S ; Shokat, Kevan M
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2007-12, Vol.3 (12), p.739-744
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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin
Author / Creator:Chen, Ligong ; Shu, Yan ; Liang, Xiaomin ; Chen, Eugene C. ; Yee, Sook Wah ; Zur, Arik A. ; Li, Shuanglian ; Xu, Lu ; Keshari, Kayvan R. ; Lin, Michael J. ; Chien, Huan-Chieh ; Zhang, Youcai ; Morrissey, Kari M. ; Liu, Jason ; Ostrem, Jonathan ; Younger, Noah S. ; Kurhanewicz, John ; Shokat, Keven M. ; Ashrafi, Kaveh ; Giacomini, Kathleen M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (27), p.9983-9988
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Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice
Author / Creator:Ehinger, Yann ; Zhang, Ziyang ; Phamluong, Khanhky ; Soneja, Drishti ; Shokat, Kevan M. ; Ron, Dorit
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-07, Vol.12 (1), p.4407-4407, Article 4407
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Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling
Author / Creator:Tan, Ying Xim ; Manz, Boryana N ; Freedman, Tanya S ; Zhang, Chao ; Shokat, Kevan M ; Weiss, Arthur
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2014-02, Vol.15 (2), p.186-194
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ArticlesPeer ReviewedFull Text
Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates
Author / Creator:Blethrow, Justin D ; Glavy, Joseph S ; Morgan, David O ; Shokat, Kevan M
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-02, Vol.105 (5), p.1442-1447
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Rewiring of Genetic Networks in Response to DNA Damage
Author / Creator:Bandyopadhyay, Sourav ; Mehta, Monika ; Kuo, Dwight ; Sung, Min-Kyung ; Chuang, Ryan ; Jaehnig, Eric J ; Bodenmiller, Bernd ; Licon, Katherine ; Copeland, Wilbert ; Shales, Michael ; Fiedler, Dorothea ; Dutkowski, Janusz ; Guénolé, Aude ; van Attikum, Haico ; Shokat, Kevan M ; Kolodner, Richard D ; Huh, Won-Ki ; Aebersold, Ruedi ; Keogh, Michael-Christopher ; Krogan, Nevan J ; Ideker, Trey
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-12, Vol.330 (6009), p.1385-1389
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Shokat, Kevan M

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Shokat, Kevan M

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Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

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Evolutionarily divergent mTOR remodels translatome for tissue regeneration

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Chemical genetic discovery of targets and anti-targets for cancer polypharmacology

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Site-specific incorporation of phosphotyrosine using an expanded genetic code

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Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

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Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

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IRE1 Signaling Affects Cell Fate During the Unfolded Protein Response

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sharp T-cell antigen receptor signaling threshold for T-cell proliferation

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T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

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Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3

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Recognizing and exploiting differences between RNAi and small-molecule inhibitors

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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin

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Brain-specific inhibition of mTORC1 eliminates side effects resulting from mTORC1 blockade in the periphery and reduces alcohol intake in mice

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Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

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Covalent capture of kinase-specific phosphopeptides reveals Cdk1-cyclin B substrates

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Rewiring of Genetic Networks in Response to DNA Damage

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