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ArticlesPeer ReviewedFull Text
Structural insights into µ-opioid receptor activation
Author / Creator:Huang, Weijiao ; Manglik, Aashish ; Venkatakrishnan, A. J. ; Laeremans, Toon ; Feinberg, Evan N. ; Sanborn, Adrian L. ; Kato, Hideaki E. ; Livingston, Kathryn E. ; Thorsen, Thor S. ; Kling, Ralf C. ; Granier, Sébastien ; Gmeiner, Peter ; Husbands, Stephen M. ; Traynor, John R. ; Weis, William I. ; Steyaert, Jan ; Dror, Ron O. ; Kobilka, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-08, Vol.524 (7565), p.315-321
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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody
Author / Creator:Ring, Aaron M. ; Manglik, Aashish ; Kruse, Andrew C. ; Enos, Michael D. ; Weis, William I. ; Garcia, K. Christopher ; Kobilka, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-10, Vol.502 (7472), p.575-579
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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
Author / Creator:DeVree, Brian T. ; Mahoney, Jacob P. ; Vélez-Ruiz, Gisselle A. ; Rasmussen, Soren G. F. ; Kuszak, Adam J. ; Edwald, Elin ; Fung, Juan-Jose ; Manglik, Aashish ; Masureel, Matthieu ; Du, Yang ; Matt, Rachel A. ; Pardon, Els ; Steyaert, Jan ; Kobilka, Brian K. ; Sunahara, Roger K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-07, Vol.535 (7610), p.182-186
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ArticlesPeer ReviewedFull Text
Propagation of conformational changes during μ-opioid receptor activation
Author / Creator:Sounier, Rémy ; Mas, Camille ; Steyaert, Jan ; Laeremans, Toon ; Manglik, Aashish ; Huang, Weijiao ; Kobilka, Brian K. ; Déméné, Héléne ; Granier, Sébastien
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-08, Vol.524 (7565), p.375-378
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ArticlesPeer ReviewedFull Text
Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
Author / Creator:Niewoehner, Jens ; Bohrmann, Bernd ; Collin, Ludovic ; Urich, Eduard ; Sade, Hadassah ; Maier, Peter ; Rueger, Petra ; Stracke, Jan Olaf ; Lau, Wilma ; Tissot, Alain C ; Loetscher, Hansruedi ; Ghosh, Anirvan ; Freskgård, Per-Ola
Publisher:United States: Elsevier Limited
Journal title:Neuron (Cambridge, Mass.), 2014-01, Vol.81 (1), p.49-60
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ArticlesPeer ReviewedFull Text
Targeting loss of heterozygosity for cancer-specific immunotherapy
Author / Creator:Hwang, Michael S. ; Mog, Brian J. ; Douglass, Jacqueline ; Pearlman, Alexander H. ; Hsiue, Emily Han-Chung ; Paul, Suman ; DiNapoli, Sarah R. ; Konig, Maximilian F. ; Pardoll, Drew M. ; Gabelli, Sandra B. ; Bettegowda, Chetan ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Zhou, Shibin ; Kinzler, Kenneth W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (12), p.1-10
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ArticlesPeer ReviewedFull Text
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection
Author / Creator:Yao, Hangping ; Sun, Yao ; Deng, Yong-Qiang ; Wang, Nan ; Tan, Yongcong ; Zhang, Na-Na ; Li, Xiao-Feng ; Kong, Chao ; Xu, Yan-Peng ; Chen, Qi ; Cao, Tian-Shu ; Zhao, Hui ; Yan, Xintian ; Cao, Lei ; Lv, Zhe ; Zhu, Dandan ; Feng, Rui ; Wu, Nanping ; Zhang, Wenhai ; Hu, Yuhao ; Chen, Keda ; Zhang, Rong-Rong ; Lv, Qingyu ; Sun, Shihui ; Zhou, Yunhua ; Yan, Run ; Yang, Guan ; Sun, Xinglu ; Liu, Chanjuan ; Lu, Xiangyun ; Cheng, Linfang ; Qiu, Hongying ; Huang, Xing-Yao ; Weng, Tianhao ; Shi, Danrong ; Jiang, Weidong ; Shao, Junbin ; Wang, Lei ; Zhang, Jie ; Jiang, Tao ; Lang, Guojun ; Qin, Cheng-Feng ; Li, Lanjuan ; Wang, Xiangxi
Publisher:Singapore: Springer Singapore
Journal title:Cell research, 2021-01, Vol.31 (1), p.25-36
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ArticlesPeer ReviewedFull Text
Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity
Author / Creator:Pai, Chien-Chun Steven ; Simons, Donald M ; Lu, Xiaoqing ; Evans, Michael ; Wei, Junnian ; Wang, Yung-Hua ; Chen, Mingyi ; Huang, John ; Park, Chanhyuk ; Chang, Anthony ; Wang, Jiaxi ; Westmoreland, Susan ; Beam, Christine ; Banach, Dave ; Bowley, Diana ; Dong, Feng ; Seagal, Jane ; Ritacco, Wendy ; Richardson, Paul L ; Mitra, Soumya ; Lynch, Grace ; Bousquet, Pete ; Mankovich, John ; Kingsbury, Gillian ; Fong, Lawrence
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-01, Vol.129 (1), p.349-363
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ArticlesPeer ReviewedFull Text
Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors
Author / Creator:Yang, Meijia ; Tang, Xin ; Zhang, Zongliang ; Gu, Lei ; Wei, Heng ; Zhao, Shasha ; Zhong, Kunhong ; Mu, Min ; Huang, Cheng ; Jiang, Caiying ; Xu, Jianguo ; Guo, Gang ; Zhou, Liangxue ; Tong, Aiping
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2020-01, Vol.10 (17), p.7622-7634
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ArticlesPeer ReviewedFull Text
Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies
Author / Creator:Armstrong, Lee A ; Lange, Sven M ; Dee Cesare, Virginia ; Matthews, Stephen P ; Nirujogi, Raja Sekhar ; Cole, Isobel ; Hope, Anthony ; Cunningham, Fraser ; Toth, Rachel ; Mukherjee, Rukmini ; Bojkova, Denisa ; Gruber, Franz ; Gray, David ; Wyatt, Paul G ; Cinatl, Jindrich ; Dikic, Ivan ; Davies, Paul ; Kulathu, Yogesh
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-07, Vol.16 (7), p.e0253364
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ArticlesPeer ReviewedFull Text
Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma
Author / Creator:Li, Nan ; Fu, Haiying ; Hewitt, Stephen M. ; Dimitrov, Dimiter S. ; Ho, Mitchell
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-08, Vol.114 (32), p.E6623-E6631
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ArticlesPeer ReviewedFull Text
Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma
Author / Creator:Feng, Mingqian ; Gao, Wei ; Wang, Ruoqi ; Chen, Weizao ; Man, Yan-Gao ; Figg, William Douglas ; Wang, Xin Wei ; Dimitrov, Dimiter S ; Ho, Mitchell
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (12), p.E1083-E1091
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ArticlesPeer ReviewedFull Text
Human antibodies neutralizing diphtheria toxin in vitro and in vivo
Author / Creator:Wenzel, Esther Veronika ; Bosnak, Margarita ; Tierney, Robert ; Schubert, Maren ; Brown, Jeffrey ; Dübel, Stefan ; Efstratiou, Androulla ; Sesardic, Dorothea ; Stickings, Paul ; Hust, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-01, Vol.10 (1), p.571, Article 571
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ArticlesPeer ReviewedFull Text
Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor
Author / Creator:Wang, Linya ; Garg, Pankaj ; Chan, Kara Y ; Yuan, Tom Z ; Lujan Hernandez, Ana G ; Han, Zhen ; Peterson, Sean M ; Tuscano, Emily ; Safavi, Crystal ; Kwan, Eric ; Villalta, Mouna ; Mathur, Melina ; Lai, Joyce ; Axelrod, Fumiko ; Souders, Colby A ; Emery, Chloe ; Sato, Aaron K
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-06, Vol.19 (6), p.e0301223
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ArticlesPeer ReviewedFull Text
Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death
Author / Creator:Qiang, Min ; Dong, Xue ; Zha, Zhao ; Zuo, Xiao-Kun ; Song, Xing-Lei ; Zhao, Lixia ; Yuan, Chao ; Huang, Chen ; Tao, Pingdong ; Hu, Qin ; Li, Wei-Guang ; Hu, Wanhui ; Li, Jie ; Nie, Yan ; Buratto, Damiano ; Zonta, Francesco ; Ma, Peixiang ; Yu, Zheng ; Liu, Lili ; Zhang, Yi ; Yang, Bei ; Xie, Jia ; Xu, Tian-Le ; Qu, Zhihu ; Yang, Guang ; Lerner, Richard A.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-08, Vol.115 (32), p.E7469-E7477
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ArticlesPeer ReviewedFull Text
Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity
Author / Creator:Steinhardt, James J. ; Guenaga, Javier ; Turner, Hannah L. ; McKee, Krisha ; Louder, Mark K. ; O’Dell, Sijy ; Chiang, Chi-I ; Lei, Lin ; Galkin, Andrey ; Andrianov, Alexander K. ; A. Doria-Rose, Nicole ; Bailer, Robert T. ; Ward, Andrew B. ; Mascola, John R. ; Li, Yuxing
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-02, Vol.9 (1), p.877-12, Article 877
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A Cell-Penetrating Peptide Improves Anti-HER2 Single-Chain Variable Fragment Internalization and Antitumor Activity against HER2-Positive Breast Cancer In Vitro and In Vivo
Author / Creator:Li, Junmin ; Zhou, Yanting ; Su, Zhuowei ; Li, Xue ; Zhang, Lei ; Li, Shan
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-03, Vol.29 (6), p.1247
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ArticlesPeer ReviewedFull Text
Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library
Author / Creator:Merkouris, Spyros ; Barde, Yves-Alain ; Binley, Kate E. ; Allen, Nicholas D. ; Stepanov, Alexey V. ; Wu, Nicholas C. ; Grande, Geramie ; Lin, Chih-Wei ; Li, Meng ; Nan, Xinsheng ; Chacon-Fernandez, Pedro ; DiStefano, Peter S. ; Lindsay, Ronald M. ; Lerner, Richard A. ; Xie, Jia
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (30), p.E7023-E7032
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ArticlesPeer ReviewedFull Text
Nicotiana benthamiana-derived dupilumab-scFv reaches deep into the cultured human nasal epithelial cells and inhibits CCL26 expression
Author / Creator:Kwon, Beom Jun ; Cho, Na Hyun ; Ahn, Taeyoung ; Kim, Geunah ; Diệu, Nguyễn Thị Xuân ; Kim, Woo Taek ; Cho, Hyung-Ju ; Seo, Dong Hye ; Kim, Joo Young
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-06, Vol.14 (1), p.14558-10, Article 14558
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Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model
Author / Creator:Song, Min-young ; Cho, Jaewon ; Park, Hyosung ; Song, Yujeong ; Kim, Keon ; Ahn, Jae-Hee ; Lee, Chang-Min ; Kim, Dae Hee ; Ko, Hyun-Jeong
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.7574
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Structural insights into µ-opioid receptor activation

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

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Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

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Propagation of conformational changes during μ-opioid receptor activation

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Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

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Targeting loss of heterozygosity for cancer-specific immunotherapy

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Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

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Tumor-conditional anti-CTLA4 uncouples antitumor efficacy from immunotherapy-related toxicity

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Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors

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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

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Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma

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Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

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Human antibodies neutralizing diphtheria toxin in vitro and in vivo

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Discovery of a potent, selective, and tumor-suppressing antibody antagonist of adenosine A2A receptor

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Selection of an ASIC1a-blocking combinatorial antibody that protects cells from ischemic death

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Rational design of a trispecific antibody targeting the HIV-1 Env with elevated anti-viral activity

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A Cell-Penetrating Peptide Improves Anti-HER2 Single-Chain Variable Fragment Internalization and Antitumor Activity against HER2-Positive Breast Cancer In Vitro and In Vivo

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Fully human agonist antibodies to TrkB using autocrine cell-based selection from a combinatorial antibody library

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Nicotiana benthamiana-derived dupilumab-scFv reaches deep into the cultured human nasal epithelial cells and inhibits CCL26 expression

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Discovery and functional characterization of canine PD-L1-targeted antibodies for evaluating antitumor efficacy in a canine osteosarcoma xenograft model

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