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ArticlesPeer ReviewedFull Text
Structural insights into TSC complex assembly and GAP activity on Rheb
Author / Creator:Yang, Huirong ; Yu, Zishuo ; Chen, Xizi ; Li, Jiabei ; Li, Ningning ; Cheng, Jiaxuan ; Gao, Ning ; Yuan, Hai-Xin ; Ye, Dan ; Guan, Kun-Liang ; Xu, Yanhui
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.339-339, Article 339
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ArticlesPeer ReviewedFull Text
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Author / Creator:Giamundo, Giuliana ; Intartaglia, Daniela ; Del Prete, Eugenio ; Polishchuk, Elena ; Andreone, Fabrizio ; Ognibene, Marzia ; Buonocore, Sara ; Hay Mele, Bruno ; Salierno, Francesco Giuseppe ; Monfregola, Jlenia ; Antonini, Dario ; Grumati, Paolo ; Eva, Alessandra ; De Cegli, Rossella ; Conte, Ivan
Publisher:England: eLife Sciences Publications, Ltd
Journal title:eLife, 2025-02, Vol.13
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ArticlesPeer ReviewedFull Text
TSC complex decrease the expression of mTOR by regulated miR-199b-3p
Author / Creator:Zhao, Na ; Xiong, Qiuhong ; Li, Ping ; Chen, Guangxin ; Xiao, Han ; Wu, Changxin
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-01, Vol.15 (1), p.1892-11, Article 1892
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ArticlesPeer ReviewedFull Text
Publisher Correction: TSC complex decrease the expression of mTOR by regulated miR-199b-3p
Author / Creator:Zhao, Na ; Xiong, Qiuhong ; Li, Ping ; Chen, Guangxin ; Xiao, Han ; Wu, Changxin
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-06, Vol.15 (1), p.19421-6
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ArticlesPeer ReviewedFull Text
Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs
Author / Creator:Liko, Dritan ; Rzepiela, Andrzej ; Vukojevic, Vanja ; Zavolan, Mihaela ; Hall, Michael N.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (3), p.1524-1532
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ArticlesPeer ReviewedFull Text
Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase
Author / Creator:Fukuda, Tomoyuki ; Sofyantoro, Fajar ; Tai, Yen Teng ; Chia, Kim Hou ; Matsuda, Takato ; Murase, Takaaki ; Morozumi, Yuichi ; Tatebe, Hisashi ; Kanki, Tomotake ; Shiozaki, Kazuhiro
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2021-02, Vol.10
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ArticlesPeer ReviewedFull Text
Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content
Author / Creator:Zadjali, Fahad ; Kumar, Prashant ; Yao, Ying ; Johnson, Daniel ; Astrinidis, Aristotelis ; Vogel, Peter ; Gross, Kenneth W. ; Bissler, John J.
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-03, Vol.21 (5), p.1729
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Newsletter articlesFull Text
Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling
Publisher:NewsRX LLC
Journal title:Life Science Weekly, 2024, p.1314
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ArticlesFull Text
G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules
Author / Creator:Prentzell, Mirja T ; Rehbein, Ulrike ; Marti Cadena Sandoval ; Ann-Sofie De Meulemeester ; Baumeister, Ralf ; Brohée, Laura ; Berdel, Bianca ; Bockwoldt, Mathias ; Carroll, Bernadette ; Andreas Von Deimling ; Demetriades, Constantinos ; Figlia, Gianluca ; Heberle, Alexander M ; Heiland, Ines ; Holzwarth, Birgit ; Huber, Lukas A ; Jaworski, Jacek ; Kern, Katharina ; Kopach, Andrii ; Korolchuk, Viktor I ; Ineke Van ’t Land-Kuper ; Macias, Matylda ; Nellist, Mark ; Pusch, Stefan ; Reil, Michele ; Reintjes, Anja ; Reuter, Friederike ; Scheldeman, Chloë ; Stefan, Eduard ; Teleman, Aurelio ; Torres-Quesada, Omar ; Trump, Saskia ; De Witte, Peter ; Yordanov, Teodor ; Opitz, Christiane A ; Thedieck, Kathrin
Publisher:Cold Spring Harbor: Cold Spring Harbor Laboratory Press
Journal title:bioRxiv, 2020-10
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ArticlesFull Text
Findings on Science Reported by Investigators at Fudan University (Structural Insights Into Tsc Complex Assembly and Gap Activity On Rheb)
Publisher:NewsRX LLC
Journal title:Obesity, fitness, & wellness week, 2021-07, p.2718
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Newsletter articlesFull Text
Data on Cell and Developmental Biology Discussed by Researchers at University of Innsbruck (The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back)
Publisher:NewsRX LLC
Journal title:Health & Medicine Week, 2021, p.1565
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ArticlesPeer ReviewedFull Text
ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
Author / Creator:Liu, Mingdong ; Zeng, Taoling ; Zhang, Xin ; Liu, Chunyan ; Wu, Zhihui ; Yao, Luming ; Xie, Changchuan ; Xia, Hui ; Lin, Qi ; Xie, Liping ; Zhou, Dawang ; Deng, Xianming ; Chan, Hong-Lin ; Zhao, Tong-Jin ; Wang, Hong-Rui
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4139-14, Article 4139
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Newsletter articlesFull Text
Studies from Salk Institute for Biological Studies Have Provided New Data on Type 2 Diabetes (Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Compl...
Publisher:NewsRX LLC
Journal title:Drug Week, 2017, p.3974
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Newsletter articlesFull Text
Data from Harvard School of Public Health Provide New Insights into Ischemia (The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo)
Publisher:NewsRX LLC
Journal title:Blood Weekly, 2015, p.33
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ArticlesPeer ReviewedFull Text
Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
Author / Creator:Deng, Lu ; Chen, Lei ; Zhao, Linlin ; Xu, Yan ; Peng, Xiaoping ; Wang, Xinbo ; Ding, Lin ; Jin, Jiali ; Teng, Hongqi ; Wang, Yanming ; Pan, Weijuan ; Yu, Fei ; Liao, Lujian ; Li, Li ; Ge, Xin ; Wang, Ping
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2019-02, Vol.29 (2), p.136-150
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ArticlesPeer ReviewedFull Text
Possible mechanisms of disease development in tuberous sclerosis
Author / Creator:Jozwiak, Jaroslaw, Dr ; Jozwiak, Sergiusz, Prof ; Wlodarski, Pawel, MD
Publisher:England: Elsevier Ltd
Journal title:The lancet oncology, 2008, Vol.9 (1), p.73-79
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ArticlesPeer ReviewedFull Text
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
Author / Creator:Carroll, Bernadette ; Maetzel, Dorothea ; Maddocks, Oliver DK ; Otten, Gisela ; Ratcliff, Matthew ; Smith, Graham R ; Dunlop, Elaine A ; Passos, João F ; Davies, Owen R ; Jaenisch, Rudolf ; Tee, Andrew R ; Sarkar, Sovan ; Korolchuk, Viktor I
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2016-01, Vol.5
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ArticlesPeer ReviewedFull Text
Multiple amino acid sensing inputs to mTORC1
Author / Creator:Shimobayashi, Mitsugu ; Hall, Michael N
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2016-01, Vol.26 (1), p.7-20
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ArticlesPeer ReviewedFull Text
The Genetics of Tuberous Sclerosis Complex and Related mTORopathies: Current Understanding and Future Directions
Author / Creator:Man, Alice ; Di Scipio, Matteo ; Grewal, Shan ; Suk, Yujin ; Trinari, Elisabetta ; Ejaz, Resham ; Whitney, Robyn
Publisher:Switzerland: MDPI AG
Journal title:Genes, 2024-03, Vol.15 (3), p.332
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ArticlesPeer ReviewedFull Text
DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity
Author / Creator:Wang, Pinhua ; Sarkar, Sunayana ; Zhang, Menghuan ; Xiao, Tingting ; Kong, Fenhua ; Zhang, Zhe ; Balasubramanian, Deepa ; Jayaram, Nandan ; Datta, Sayantan ; He, Ruyu ; Wu, Ping ; Chao, Peng ; Zhang, Ying ; Washburn, Michael ; Florens, Laurence A ; Nagarkar-Jaiswal, Sonal ; Jaiswal, Manish ; Mohan, Man
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2024-10, Vol.12
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Showing 1 to 20 of 57 results

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Structural insights into TSC complex assembly and GAP activity on Rheb

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Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

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TSC complex decrease the expression of mTOR by regulated miR-199b-3p

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Publisher Correction: TSC complex decrease the expression of mTOR by regulated miR-199b-3p

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Loss of TSC complex enhances gluconeogenesis via upregulation of Dlk1-Dio3 locus miRNAs

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Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 complex, the TSC complex, and Gcn2 kinase

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Tuberous Sclerosis Complex Axis Controls Renal Extracellular Vesicle Production and Protein Content

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Ezrin defines TSC complex activation at endosomal compartments through EGFR-AKT signaling

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G3BP1 tethers the TSC complex to lysosomes and suppresses mTORC1 in the absence of stress granules

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Findings on Science Reported by Investigators at Fudan University (Structural Insights Into Tsc Complex Assembly and Gap Activity On Rheb)

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Data on Cell and Developmental Biology Discussed by Researchers at University of Innsbruck (The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back)

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ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage

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Studies from Salk Institute for Biological Studies Have Provided New Data on Type 2 Diabetes (Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Compl...

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Data from Harvard School of Public Health Provide New Insights into Ischemia (The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo)

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Ubiquitination of Rheb governs growth factor-induced mTORC1 activation

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Possible mechanisms of disease development in tuberous sclerosis

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Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

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Multiple amino acid sensing inputs to mTORC1

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The Genetics of Tuberous Sclerosis Complex and Related mTORopathies: Current Understanding and Future Directions

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DYRK1A interacts with the tuberous sclerosis complex and promotes mTORC1 activity

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