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ArticlesPeer ReviewedFull Text
Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease
Author / Creator:Esrick, Erica B ; Lehmann, Leslie E ; Biffi, Alessandra ; Achebe, Maureen ; Brendel, Christian ; Ciuculescu, Marioara F ; Daley, Heather ; MacKinnon, Brenda ; Morris, Emily ; Federico, Amy ; Abriss, Daniela ; Boardman, Kari ; Khelladi, Radia ; Shaw, Kit ; Negre, Helene ; Negre, Olivier ; Nikiforow, Sarah ; Ritz, Jerome ; Pai, Sung-Yun ; London, Wendy B ; Dansereau, Colleen ; Heeney, Matthew M ; Armant, Myriam ; Manis, John P ; Williams, David A
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2021-01, Vol.384 (3), p.205-215
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Therapeutic base editing of human hematopoietic stem cells
Author / Creator:Zeng, Jing ; Wu, Yuxuan ; Ren, Chunyan ; Bonanno, Jasmine ; Shen, Anne H. ; Shea, Devlin ; Gehrke, Jason M. ; Clement, Kendell ; Luk, Kevin ; Yao, Qiuming ; Kim, Rachel ; Wolfe, Scot A. ; Manis, John P. ; Pinello, Luca ; Joung, J. Keith ; Bauer, Daniel E.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-04, Vol.26 (4), p.535-541
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Transcription factor competition at the γ-globin promoters controls hemoglobin switching
Author / Creator:Liu, Nan ; Xu, Shuqian ; Yao, Qiuming ; Zhu, Qian ; Kai, Yan ; Hsu, Jonathan Y. ; Sakon, Phraew ; Pinello, Luca ; Yuan, Guo-Cheng ; Bauer, Daniel E. ; Orkin, Stuart H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2021-04, Vol.53 (4), p.511-520
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Potent and uniform fetal hemoglobin induction via base editing
Author / Creator:Mayuranathan, Thiyagaraj ; Newby, Gregory A. ; Feng, Ruopeng ; Yao, Yu ; Mayberry, Kalin D. ; Lazzarotto, Cicera R. ; Li, Yichao ; Levine, Rachel M. ; Nimmagadda, Nikitha ; Dempsey, Erin ; Kang, Guolian ; Porter, Shaina N. ; Doerfler, Phillip A. ; Zhang, Jingjing ; Jang, Yoonjeong ; Chen, Jingjing ; Bell, Henry W. ; Crossley, Merlin ; Bhoopalan, Senthil Velan ; Sharma, Akshay ; Tisdale, John F. ; Pruett-Miller, Shondra M. ; Cheng, Yong ; Tsai, Shengdar Q. ; Liu, David R. ; Weiss, Mitchell J. ; Yen, Jonathan S.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2023-07, Vol.55 (7), p.1210-1220
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Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells
Author / Creator:Qin, Kunhua ; Huang, Peng ; Feng, Ruopeng ; Keller, Cheryl A. ; Peslak, Scott A. ; Khandros, Eugene ; Saari, Megan S. ; Lan, Xianjiang ; Mayuranathan, Thiyagaraj ; Doerfler, Phillip A. ; Abdulmalik, Osheiza ; Giardine, Belinda ; Chou, Stella T. ; Shi, Junwei ; Hardison, Ross C. ; Weiss, Mitchell J. ; Blobel, Gerd A.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2022-06, Vol.54 (6), p.874-884
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The induction effect of hydroxyurea and metformin on fetal globin in the K562 cell line
Author / Creator:Eini, Mohammad ; Safarpour, Hossain ; Miri-Moghddam, Ebrahim
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2025-04, Vol.31 (1), p.132, Article 132
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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A
Author / Creator:Sankaran, Vijay G ; Menne, Tobias F ; Xu, Jian ; Akie, Thomas E ; Lettre, Guillaume ; Van Handel, Ben ; Mikkola, Hanna K.A ; Hirschhorn, Joel N ; Cantor, Alan B ; Orkin, Stuart H
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2008-12, Vol.322 (5909), p.1839-1842
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An α-chain modification rivals the effect of fetal hemoglobin in retarding the rate of sickle cell fiber formation
Author / Creator:Worth, Eli H. ; Fugate, Mark K. ; Grasty, Kimberly C. ; Loll, Patrick J. ; Bishop, Marilyn F. ; Ferrone, Frank A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-12, Vol.13 (1), p.21997-21997, Article 21997
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The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
Author / Creator:Zuccato, Cristina ; Cosenza, Lucia Carmela ; Zurlo, Matteo ; Breveglieri, Giulia ; Bianchi, Nicoletta ; Lampronti, Ilaria ; Gasparello, Jessica ; Scapoli, Chiara ; Borgatti, Monica ; Finotti, Alessia ; Gambari, Roberto
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2023-01, Vol.24 (1), p.776
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ArticlesPeer ReviewedFull Text
IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts
Author / Creator:de Vasconcellos, Jaira F. ; Tumburu, Laxminath ; Byrnes, Colleen ; Lee, Y. Terry ; Xu, Pauline C. ; Li, May ; Rabel, Antoinette ; Clarke, Benjamin A. ; Guydosh, Nicholas R. ; Proia, Richard L. ; Miller, Jeffery L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (28), p.E5664-E5672
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Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies
Author / Creator:Paschoudi, Kiriaki ; Yannaki, Evangelia ; Psatha, Nikoletta
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-05, Vol.24 (11), p.9527
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ArticlesPeer ReviewedFull Text
BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression
Author / Creator:Gasparello, Jessica ; Fabbri, Enrica ; Bianchi, Nicoletta ; Breveglieri, Giulia ; Zuccato, Cristina ; Borgatti, Monica ; Gambari, Roberto ; Finotti, Alessia
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2017-11, Vol.18 (12), p.2530
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ArticlesPeer ReviewedFull Text
Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies
Author / Creator:Chandraprabha, Prathibha Babu ; Azhagiri, Manoj Kumar K ; Venkatesan, Vigneshwaran ; Magis, Wendy ; Prasad, Kirti ; Suresh, Sevanthy ; Pai, Aswin Anand ; Marepally, Srujan ; Srivastava, Alok ; Mohankumar, Kumarasamypet Murugesan ; Martin, David I K ; Thangavel, Saravanabhavan
Publisher:England: BioMed Central
Journal title:Stem cell research & therapy, 2024-12, Vol.15 (1), p.504-19, Article 504
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Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia
Author / Creator:Bao, Xiuqin ; Gao, Yuanyi ; Wang, Zhongju ; Ye, Yuhua ; Chen, Diyu ; Zuo, Yangjin ; Zhao, Cunyou ; Xu, Xiangmin
Publisher:Germany: BioMed Central
Journal title:Clinical epigenetics, 2024-01, Vol.16 (1), p.12-12, Article 12
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Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching
Author / Creator:Habara, Alawi
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2025-02, Vol.14 (4), p.312
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miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A
Author / Creator:Gholampour, Mohammad Ali ; Asadi, Marjan ; Naderi, Mehran ; Azarkeivan, Azita ; Soleimani, Masoud ; Atashi, Amir
Publisher:Dordrecht: Springer Netherlands
Journal title:Molecular biology reports, 2020-05, Vol.47 (5), p.3909-3918
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MiR-27a Promotes Hemin-Induced Erythroid Differentiation of K562 Cells by Targeting CDC25B
Author / Creator:Wang, Dongsheng ; Si, Si ; Wang, Qiang ; Luo, Guangcheng ; Du, Qin ; Liang, Qi ; Guo, Xiaolan ; Zhang, Guoyuan ; Feng, Jiafu ; Leng, Zhengwei
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Cellular physiology and biochemistry, 2018-04, Vol.46 (1), p.365-374
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ArticlesPeer ReviewedFull Text
Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences
Author / Creator:Finotti, Alessia ; Gasparello, Jessica ; Zuccato, Cristina ; Cosenza, Lucia Carmela ; Fabbri, Enrica ; Bianchi, Nicoletta ; Gambari, Roberto
Publisher:Switzerland: MDPI AG
Journal title:Genes, 2023-10, Vol.14 (10), p.1927
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Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia
Author / Creator:Gemmo, Chiara ; Breveglieri, Giulia ; Marzaro, Giovanni ; Lampronti, Ilaria ; Cosenza, Lucia Carmela ; Gasparello, Jessica ; Zuccato, Cristina ; Fabbri, Enrica ; Borgatti, Monica ; Chilin, Adriana ; Finotti, Alessia ; Gambari, Roberto
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2019-11, Vol.411 (29), p.7699-7707
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ArticlesPeer ReviewedFull Text
HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts
Author / Creator:de Vasconcellos, Jaira F ; Lee, Y Terry ; Byrnes, Colleen ; Tumburu, Laxminath ; Rabel, Antoinette ; Miller, Jeffery L
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-11, Vol.11 (11), p.e0166928-e0166928
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Showing 1 to 20 of 40 results

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Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease

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Therapeutic base editing of human hematopoietic stem cells

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Transcription factor competition at the γ-globin promoters controls hemoglobin switching

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Potent and uniform fetal hemoglobin induction via base editing

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Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells

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The induction effect of hydroxyurea and metformin on fetal globin in the K562 cell line

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Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A

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An α-chain modification rivals the effect of fetal hemoglobin in retarding the rate of sickle cell fiber formation

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The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers

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IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts

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Precision Editing as a Therapeutic Approach for β-Hemoglobinopathies

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BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression

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Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies

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Activation of γ-globin expression by LncRNA-mediated ERF promoter hypermethylation in β-thalassemia

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Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching

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miR-30a regulates γ-globin expression in erythoid precursors of intermedia thalassemia through targeting BCL11A

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MiR-27a Promotes Hemin-Induced Erythroid Differentiation of K562 Cells by Targeting CDC25B

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Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences

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Surface plasmon resonance based analysis of the binding of LYAR protein to the rs368698783 (G>A) polymorphic Aγ-globin gene sequences mutated in β-thalassemia

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HMGA2 Moderately Increases Fetal Hemoglobin Expression in Human Adult Erythroblasts

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