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421 results for rac1+GTP-Binding+Protein+-+genetics

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Select record 21
ArticlesPeer ReviewedFull Text
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation
Author / Creator:Zhang, Pingzhao ; Wang, Dejie ; Zhao, Yu ; Ren, Shancheng ; Gao, Kun ; Ye, Zhenqing ; Wang, Shangqian ; Pan, Chun-Wu ; Zhu, Yasheng ; Yan, Yuqian ; Yang, Yinhui ; Wu, Di ; He, Yundong ; Zhang, Jun ; Lu, Daru ; Liu, Xiuping ; Yu, Long ; Zhao, Shimin ; Li, Yao ; Lin, Dong ; Wang, Yuzhuo ; Wang, Liguo ; Chen, Yu ; Sun, Yinghao ; Wang, Chenji ; Huang, Haojie
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-09, Vol.23 (9), p.1055-1062
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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Author / Creator:Krauthammer, Michael ; Kong, Yong ; Ha, Byung Hak ; Evans, Perry ; Bacchiocchi, Antonella ; McCusker, Jamie P ; Cheng, Elaine ; Davis, Matthew J ; Goh, Gerald ; Choi, Murim ; Ariyan, Stephan ; Narayan, Deepak ; Dutton-Regester, Ken ; Capatana, Ana ; Holman, Edna C ; Bosenberg, Marcus ; Sznol, Mario ; Kluger, Harriet M ; Brash, Douglas E ; Stern, David F ; Materin, Miguel A ; Lo, Roger S ; Mane, Shrikant ; Ma, Shuangge ; Kidd, Kenneth K ; Hayward, Nicholas K ; Lifton, Richard P ; Schlessinger, Joseph ; Boggon, Titus J ; Halaban, Ruth
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2012-09, Vol.44 (9), p.1006-1014
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Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function
Author / Creator:Guo, Daji ; Peng, Yinghui ; Wang, Laijian ; Sun, Xiaoyu ; Wang, Xiaojun ; Liang, Chunmei ; Yang, Xiaoman ; Li, Shengnan ; Xu, Junyu ; Ye, Wen-Cai ; Jiang, Bin ; Shi, Lei
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2021-05, Vol.26 (5), p.1505-1519
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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Author / Creator:Gao, Jianjiong ; Chang, Matthew T ; Johnsen, Hannah C ; Gao, Sizhi Paul ; Sylvester, Brooke E ; Sumer, Selcuk Onur ; Zhang, Hongxin ; Solit, David B ; Taylor, Barry S ; Schultz, Nikolaus ; Sander, Chris
Publisher:England: BioMed Central Ltd
Journal title:Genome medicine, 2017-01, Vol.9 (1), p.4-4, Article 4
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Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
Author / Creator:Sylow, Lykke ; Jensen, Thomas E ; Kleinert, Maximilian ; Højlund, Kurt ; Kiens, Bente ; Wojtaszewski, Jørgen ; Prats, Clara ; Schjerling, Peter ; Richter, Erik A
Publisher:United States: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-06, Vol.62 (6), p.1865-1875
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The RHO Family GTPases: Mechanisms of Regulation and Signaling
Author / Creator:Mosaddeghzadeh, Niloufar ; Ahmadian, Mohammad Reza
Publisher:Switzerland: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-07, Vol.10 (7), p.1831
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ArticlesPeer ReviewedFull Text
Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation
Author / Creator:Ogrunc, M ; Di Micco, R ; Liontos, M ; Bombardelli, L ; Mione, M ; Fumagalli, M ; Gorgoulis, V G ; d'Adda di Fagagna, F
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2014-06, Vol.21 (6), p.998-1012
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ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation
Author / Creator:Shin, Sejeong ; Buel, Gwen R. ; Nagiec, Michal J. ; Han, Min-Joon ; Roux, Philippe P. ; Blenis, John ; Yoon, Sang-Oh
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (8), p.2967-2976
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ArticlesPeer ReviewedFull Text
Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling
Author / Creator:Felcht, Moritz ; Luck, Robert ; Schering, Alexander ; Seidel, Philipp ; Srivastava, Kshitij ; Hu, Junhao ; Bartol, Arne ; Kienast, Yvonne ; Vettel, Christiane ; Loos, Elias K ; Kutschera, Simone ; Bartels, Susanne ; Appak, Sila ; Besemfelder, Eva ; Terhardt, Dorothee ; Chavakis, Emmanouil ; Wieland, Thomas ; Klein, Christian ; Thomas, Markus ; Uemura, Akiyoshi ; Goerdt, Sergij ; Augustin, Hellmut G
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2012-06, Vol.122 (6), p.1991-2005
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Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy
Author / Creator:Ma, Ning ; Xu, Erqian ; Luo, Qing ; Song, Guanbin
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.2976
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ArticlesPeer ReviewedFull Text
A genetically encoded photoactivatable Rac controls the motility of living cells
Author / Creator:Wu, Yi I. ; Frey, Daniel ; Lungu, Oana I. ; Jaehrig, Angelika ; Schlichting, Ilme ; Kuhlman, Brian ; Hahn, Klaus M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-09, Vol.461 (7260), p.104-108
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ArticlesPeer ReviewedFull Text
Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement
Author / Creator:Zhang, Xun E ; Adderley, Shaquria P ; Breslin, Jerome W
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-05, Vol.11 (5), p.e0155490
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ArticlesPeer ReviewedFull Text
Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state
Author / Creator:Chang, Leifu ; Yang, Jing ; Jo, Chang Hwa ; Boland, Andreas ; Zhang, Ziguo ; McLaughlin, Stephen H. ; Abu-Thuraia, Afnan ; Killoran, Ryan C. ; Smith, Matthew J. ; Côté, Jean-Francois ; Barford, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3464-3464, Article 3464
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Select record 34
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Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1
Author / Creator:Wang, P ; Chen, L ; Zhang, J ; Chen, H ; Fan, J ; Wang, K ; Luo, J ; Chen, Z ; Meng, Z ; Liu, L
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2014-01, Vol.33 (4), p.514-524
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ArticlesPeer ReviewedFull Text
Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation
Author / Creator:Juncadella, Ignacio J. ; Kadl, Alexandra ; Sharma, Ashish K. ; Shim, Yun M. ; Hochreiter-Hufford, Amelia ; Borish, Larry ; Ravichandran, Kodi S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-01, Vol.493 (7433), p.547-551
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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression
Author / Creator:Golden, Sam A ; Christoffel, Daniel J ; Heshmati, Mitra ; Hodes, Georgia E ; Magida, Jane ; Davis, Keithara ; Cahill, Michael E ; Dias, Caroline ; Ribeiro, Efrain ; Ables, Jessica L ; Kennedy, Pamela J ; Robison, Alfred J ; Gonzalez-Maeso, Javier ; Neve, Rachael L ; Turecki, Gustavo ; Ghose, Subroto ; Tamminga, Carol A ; Russo, Scott J
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2013-03, Vol.19 (3), p.337-344
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Regulation of local GTP availability controls RAC1 activity and cell invasion
Author / Creator:Bianchi-Smiraglia, Anna ; Wolff, David W. ; Marston, Daniel J. ; Deng, Zhiyong ; Han, Zhannan ; Moparthy, Sudha ; Wombacher, Rebecca M. ; Mussell, Ashley L. ; Shen, Shichen ; Chen, Jialin ; Yun, Dong-Hyun ; O’Brien Cox, Anderson ; Furdui, Cristina M. ; Hurley, Edward ; Feltri, Maria Laura ; Qu, Jun ; Hollis, Thomas ; Kengne, Jules Berlin Nde ; Fongang, Bernard ; Sousa, Rui J. ; Kandel, Mikhail E. ; Kandel, Eugene S. ; Hahn, Klaus M. ; Nikiforov, Mikhail A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6091-6091, Article 6091
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Select record 38
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions
Author / Creator:Akula, Murali K. ; Ibrahim, Mohamed X. ; Ivarsson, Emil G. ; Khan, Omar M. ; Kumar, Israiel T. ; Erlandsson, Malin ; Karlsson, Christin ; Xu, Xiufeng ; Brisslert, Mikael ; Brakebusch, Cord ; Wang, Donghai ; Bokarewa, Maria ; Sayin, Volkan I. ; Bergo, Martin O.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-09, Vol.10 (1), p.3975-13, Article 3975
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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage
Author / Creator:Goulielmaki, Evi ; Ioannidou, Anna ; Tsekrekou, Maria ; Stratigi, Kalliopi ; Poutakidou, Ioanna K. ; Gkirtzimanaki, Katerina ; Aivaliotis, Michalis ; Evangelou, Konstantinos ; Topalis, Pantelis ; Altmüller, Janine ; Gorgoulis, Vassilis G. ; Chatzinikolaou, Georgia ; Garinis, George A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.42-18, Article 42
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Select record 40
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Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity
Author / Creator:Havel, L S ; Kline, E R ; Salgueiro, A M ; Marcus, A I
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2015-04, Vol.34 (15), p.1979-1990
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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

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Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function

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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets

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Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle

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The RHO Family GTPases: Mechanisms of Regulation and Signaling

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Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

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ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

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Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling

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Rac1: A Regulator of Cell Migration and a Potential Target for Cancer Therapy

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A genetically encoded photoactivatable Rac controls the motility of living cells

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Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement

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Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state

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Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1

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Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation

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Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

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Regulation of local GTP availability controls RAC1 activity and cell invasion

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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions

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Tissue-infiltrating macrophages mediate an exosome-based metabolic reprogramming upon DNA damage

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Vimentin regulates lung cancer cell adhesion through a VAV2–Rac1 pathway to control focal adhesion kinase activity

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