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177 results for Analgesics,+Opioid+-+chemistry

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ArticlesPeer ReviewedFull Text
A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor
Author / Creator:Dekan, Zoltan ; Sianati, Setareh ; Yousuf, Arsalan ; Sutcliffe, Katy J. ; Gillis, Alexander ; Mallet, Christophe ; Singh, Paramjit ; Jin, Aihua H. ; Wang, Anna M. ; Mohammadi, Sarasa A. ; Stewart, Michael ; Ratnayake, Ranjala ; Fontaine, Frank ; Lacey, Ernest ; Piggott, Andrew M. ; Du, Yan P. ; Canals, Meritxell ; Sessions, Richard B. ; Kelly, Eamonn ; Capon, Robert J. ; Alewood, Paul F. ; Christ, MacDonald J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (44), p.22353-22358
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Structure-based discovery of opioid analgesics with reduced side effects
Author / Creator:Manglik, Aashish ; Lin, Henry ; Aryal, Dipendra K. ; McCorvy, John D. ; Dengler, Daniela ; Corder, Gregory ; Levit, Anat ; Kling, Ralf C. ; Bernat, Viachaslau ; Hübner, Harald ; Huang, Xi-Ping ; Sassano, Maria F. ; Giguère, Patrick M. ; Löber, Stefan ; Da Duan ; Scherrer, Grégory ; Kobilka, Brian K. ; Gmeiner, Peter ; Roth, Bryan L. ; Shoichet, Brian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-09, Vol.537 (7619), p.185-190
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Insights into distinct signaling profiles of the µOR activated by diverse agonists
Author / Creator:Qu, Qianhui ; Huang, Weijiao ; Aydin, Deniz ; Paggi, Joseph M. ; Seven, Alpay B. ; Wang, Haoqing ; Chakraborty, Soumen ; Che, Tao ; DiBerto, Jeffrey F. ; Robertson, Michael J. ; Inoue, Asuka ; Suomivuori, Carl-Mikael ; Roth, Bryan L. ; Majumdar, Susruta ; Dror, Ron O. ; Kobilka, Brian K. ; Skiniotis, Georgios
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2023-04, Vol.19 (4), p.423-430
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Structure-based design of bitopic ligands for the µ-opioid receptor
Author / Creator:Faouzi, Abdelfattah ; Wang, Haoqing ; Zaidi, Saheem A. ; DiBerto, Jeffrey F. ; Che, Tao ; Qu, Qianhui ; Robertson, Michael J. ; Madasu, Manish K. ; El Daibani, Amal ; Varga, Balazs R. ; Zhang, Tiffany ; Ruiz, Claudia ; Liu, Shan ; Xu, Jin ; Appourchaux, Kevin ; Slocum, Samuel T. ; Eans, Shainnel O. ; Cameron, Michael D. ; Al-Hasani, Ream ; Pan, Ying Xian ; Roth, Bryan L. ; McLaughlin, Jay P. ; Skiniotis, Georgios ; Katritch, Vsevolod ; Kobilka, Brian K. ; Majumdar, Susruta
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-01, Vol.613 (7945), p.767-774
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A nontoxic pain killer designed by modeling of pathological receptor conformations
Author / Creator:Spahn, V. ; Del Vecchio, G. ; Labuz, D. ; Rodriguez-Gaztelumendi, A. ; Massaly, N. ; Temp, J. ; Durmaz, V. ; Sabri, P. ; Reidelbach, M. ; Machelska, H. ; Weber, M. ; Stein, C.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6328), p.966-969
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Biased Opioid Ligands
Author / Creator:Faouzi, Abdelfattah ; Varga, Balazs R ; Majumdar, Susruta
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2020-09, Vol.25 (18), p.4257
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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides
Author / Creator:Meyrath, Max ; Szpakowska, Martyna ; Zeiner, Julian ; Massotte, Laurent ; Merz, Myriam P. ; Benkel, Tobias ; Simon, Katharina ; Ohnmacht, Jochen ; Turner, Jonathan D. ; Krüger, Rejko ; Seutin, Vincent ; Ollert, Markus ; Kostenis, Evi ; Chevigné, Andy
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-06, Vol.11 (1), p.3033-3033, Article 3033
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Biased versus Partial Agonism in the Search for Safer Opioid Analgesics
Author / Creator:Azevedo Neto, Joaquim ; Costanzini, Anna ; De Giorgio, Roberto ; Lambert, David G ; Ruzza, Chiara ; Calò, Girolamo
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-08, Vol.25 (17), p.3870
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ArticlesPeer ReviewedFull Text
Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters
Author / Creator:Pidathala, Shabareesh ; Mallela, Aditya Kumar ; Joseph, Deepthi ; Penmatsa, Aravind
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2199-2199, Article 2199
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ArticlesPeer ReviewedFull Text
Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor
Author / Creator:Muratspahić, Edin ; Deibler, Kristine ; Han, Jianming ; Tomašević, Nataša ; Jadhav, Kirtikumar B. ; Olivé-Marti, Aina-Leonor ; Hochrainer, Nadine ; Hellinger, Roland ; Koehbach, Johannes ; Fay, Jonathan F. ; Rahman, Mohammad Homaidur ; Hegazy, Lamees ; Craven, Timothy W. ; Varga, Balazs R. ; Bhardwaj, Gaurav ; Appourchaux, Kevin ; Majumdar, Susruta ; Muttenthaler, Markus ; Hosseinzadeh, Parisa ; Craik, David J. ; Spetea, Mariana ; Che, Tao ; Baker, David ; Gruber, Christian W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-12, Vol.14 (1), p.8064-8064, Article 8064
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ArticlesPeer ReviewedFull Text
Kratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review
Author / Creator:Schimmel, Jonathan ; Dart, Richard C.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2020-02, Vol.80 (3), p.263-283
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In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances
Author / Creator:Vandeputte, Marthe M. ; Cannaert, Annelies ; Stove, Christophe P.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Archives of toxicology, 2020-11, Vol.94 (11), p.3819-3830
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Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach
Author / Creator:Goode-Romero, Guillermo ; Dominguez, Laura
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-07, Vol.19 (7), p.e0304068
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Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids
Author / Creator:Olson, Keith M ; Duron, David I ; Womer, Daniel ; Fell, Ryan ; Streicher, John M
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-06, Vol.14 (6), p.e0217371
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Changes in Opioid-Involved Overdose Deaths by Opioid Type and Presence of Benzodiazepines, Cocaine, and Methamphetamine — 25 States, July–December 2017 to January–June 2018
Author / Creator:Gladden, R. Matt ; O’Donnell, Julie ; Mattson, Christine L. ; Seth, Puja
Publisher:United States: Centers for Disease Control & Prevention (CDC)
Journal title:MMWR. Morbidity and mortality weekly report, 2019-08, Vol.68 (34), p.737-744
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Multifunctional Opioid-Derived Hybrids in Neuropathic Pain: Preclinical Evidence, Ideas and Challenges
Author / Creator:Starnowska-Sokół, Joanna ; Przewłocka, Barbara
Publisher:Switzerland: MDPI
Journal title:Molecules (Basel, Switzerland), 2020-11, Vol.25 (23), p.5520
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Fentanyl Formulations in the Management of Pain: An Update
Author / Creator:Schug, Stephan A. ; Ting, Sonya
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2017-05, Vol.77 (7), p.747-763
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Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs
Author / Creator:Vandeputte, Marthe M. ; Walton, Sara E. ; Shuda, Sarah A. ; Papsun, Donna M. ; Krotulski, Alex J. ; Stove, Christophe P.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Analytical and bioanalytical chemistry, 2023-09, Vol.415 (21), p.5165-5180
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Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists
Author / Creator:Guo, Yanhao ; Yu, Ruimin ; Zhang, Tao ; Ren, Fengxia ; Yu, Zixing ; Cheng, Jingchao ; Jia, Hongxin ; Shi, Weiguo ; Zhang, Yatong
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-06, Vol.29 (13), p.2961
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Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development
Author / Creator:Li, Zoe ; Huang, Ruili ; Xia, Menghang ; Chang, Nancy ; Guo, Wenjing ; Liu, Jie ; Dong, Fan ; Liu, Bailang ; Varghese, Ann ; Aslam, Aasma ; Patterson, Tucker A ; Hong, Huixiao
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2024-06, Vol.29 (11), p.2635
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A tetrapeptide class of biased analgesics from an Australian fungus targets the μ-opioid receptor

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Structure-based discovery of opioid analgesics with reduced side effects

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Insights into distinct signaling profiles of the µOR activated by diverse agonists

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Structure-based design of bitopic ligands for the µ-opioid receptor

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A nontoxic pain killer designed by modeling of pathological receptor conformations

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Biased Opioid Ligands

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The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

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Biased versus Partial Agonism in the Search for Safer Opioid Analgesics

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Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters

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Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor

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Kratom (Mitragyna Speciosa) Liver Injury: A Comprehensive Review

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In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances

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Descriptive molecular pharmacology of the δ opioid receptor (DOR): A computational study with structural approach

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Comprehensive molecular pharmacology screening reveals potential new receptor interactions for clinically relevant opioids

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Changes in Opioid-Involved Overdose Deaths by Opioid Type and Presence of Benzodiazepines, Cocaine, and Methamphetamine — 25 States, July–December 2017 to January–June 2018

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Multifunctional Opioid-Derived Hybrids in Neuropathic Pain: Preclinical Evidence, Ideas and Challenges

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Fentanyl Formulations in the Management of Pain: An Update

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Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs

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Synthesis and Biological Evaluation of Novel Biased Mu-Opioid Receptor Agonists

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Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development

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