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ArticlesPeer ReviewedFull Text
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Author / Creator:Hooftman, Alexander ; Peace, Christian G. ; Ryan, Dylan G. ; Day, Emily A. ; Yang, Ming ; McGettrick, Anne F. ; Yin, Maureen ; Montano, Erica N. ; Huo, Lihong ; Toller-Kawahisa, Juliana E. ; Zecchini, Vincent ; Ryan, Tristram A. J. ; Bolado-Carrancio, Alfonso ; Casey, Alva M. ; Prag, Hiran A. ; Costa, Ana S. H. ; De Los Santos, Gabriela ; Ishimori, Mariko ; Wallace, Daniel J. ; Venuturupalli, Swamy ; Nikitopoulou, Efterpi ; Frizzell, Norma ; Johansson, Cecilia ; Von Kriegsheim, Alexander ; Murphy, Michael P. ; Jefferies, Caroline ; Frezza, Christian ; O’Neill, Luke A. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-03, Vol.615 (7952), p.490-498
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Arginine dependence of tumor cells: targeting a chink in cancer’s armor
Author / Creator:Patil, M D ; Bhaumik, J ; Babykutty, S ; Banerjee, U C ; Fukumura, D
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2016-09, Vol.35 (38), p.4957-4972
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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
Author / Creator:Rabinovich, Shiran ; Adler, Lital ; Yizhak, Keren ; Sarver, Alona ; Silberman, Alon ; Agron, Shani ; Stettner, Noa ; Sun, Qin ; Brandis, Alexander ; Helbling, Daniel ; Korman, Stanley ; Itzkovitz, Shalev ; Dimmock, David ; Ulitsky, Igor ; Nagamani, Sandesh C. S. ; Ruppin, Eytan ; Erez, Ayelet
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-11, Vol.527 (7578), p.379-383
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FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis
Author / Creator:Sun, Wenbo ; Kou, Hengyuan ; Fang, Yao ; Xu, Fan ; Xu, Zhi ; Wang, Xiumei ; Yin, Rong ; Zhang, Qin ; Jiang, Qin ; Xu, Yong
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2024-01, Vol.43 (3), p.216-223
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Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy
Author / Creator:Changou, Chun A. ; Chen, Yun-Ru ; Xing, Li ; Yen, Yun ; Chuang, Frank Y. S. ; Cheng, R. Holland ; Bold, Richard J. ; Ann, David K. ; Kung, Hsing-Jien
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (39), p.14147-14152
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Bench-to-Bedside Studies of Arginine Deprivation in Cancer
Author / Creator:Field, George C ; Pavlyk, Iuliia ; Szlosarek, Peter W
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2023-02, Vol.28 (5), p.2150
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Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor
Author / Creator:Zou, Zizheng ; Hu, Xiyuan ; Luo, Tiao ; Ming, Zhengnan ; Chen, Xiaodan ; Xia, Li ; Luo, Wensong ; Li, Jijia ; Xu, Na ; Chen, Ling ; Cao, Dongsheng ; Wen, Min ; Kong, Fanrong ; Peng, Kunjian ; Xie, Yuanzhu ; Li, Xuan ; Ma, Dayou ; Yang, Chuanyu ; Chen, Ceshi ; Yi, Wenjun ; Liu, Ousheng ; Liu, Suyou ; Luo, Junli ; Luo, Zhiyong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-04, Vol.12 (1), p.2263-2263, Article 2263
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Hepatic urea, creatinine and uric acid metabolism in dairy cows with divergent milk urea concentrations
Author / Creator:Prahl, Marie C. ; Müller, Carolin B. M. ; Albrecht, Dirk ; Koch, Franziska ; Wimmers, Klaus ; Kuhla, Björn
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-10, Vol.12 (1), p.17593-17593, Article 17593
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Requirement of argininosuccinate lyase for systemic nitric oxide production
Author / Creator:Erez, Ayelet ; Nagamani, Sandesh C S ; Shchelochkov, Oleg A ; Premkumar, Muralidhar H ; Campeau, Philippe M ; Chen, Yuqing ; Garg, Harsha K ; Li, Li ; Mian, Asad ; Bertin, Terry K ; Black, Jennifer O ; Zeng, Heng ; Tang, Yaoping ; Reddy, Anilkumar K ; Summar, Marshall ; O'Brien, William E ; Harrison, David G ; Mitch, William E ; Marini, Juan C ; Aschner, Judy L ; Bryan, Nathan S ; Lee, Brendan
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2011-12, Vol.17 (12), p.1619-1626
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Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma
Author / Creator:Liu, Qingqing ; Stewart, John ; Wang, Hua ; Rashid, Asif ; Zhao, Jun ; Katz, Matthew H ; Lee, Jeffrey E ; Fleming, Jason B ; Maitra, Anirban ; Wolff, Robert A ; Varadhachary, Gauri R ; Krishnan, Sunil ; Wang, Huamin
Publisher:United States: Public Library of Science
Journal title:PloS one, 2017-02, Vol.12 (2), p.e0171985-e0171985
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Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
Author / Creator:Kim, Sanghwa ; Lee, Minji ; Song, Yeonhwa ; Lee, Su-Yeon ; Choi, Inhee ; Park, I-Seul ; Kim, Jiho ; Kim, Jin-Sun ; Kim, Kang Mo ; Seo, Haeng Ran
Publisher:England: BioMed Central
Journal title:Journal of experimental & clinical cancer research, 2021-04, Vol.40 (1), p.127-18, Article 127
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Citrulline metabolism in plants
Author / Creator:Joshi, Vijay ; Fernie, Alisdair R.
Publisher:Vienna: Springer Vienna
Journal title:Amino acids, 2017-09, Vol.49 (9), p.1543-1559
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Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes
Author / Creator:Alexandrou, Constantinos ; Al-Aqbi, Saif Sattar ; Higgins, Jennifer A. ; Boyle, William ; Karmokar, Ankur ; Andreadi, Catherine ; Luo, Jin-Li ; Moore, David A. ; Viskaduraki, Maria ; Blades, Matthew ; Murray, Graeme I. ; Howells, Lynne M. ; Thomas, Anne ; Brown, Karen ; Cheng, Paul N. ; Rufini, Alessandro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-08, Vol.8 (1), p.12096-14, Article 12096
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Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer Treatment
Author / Creator:Chu, Yu-De ; Lai, Ming-Wei ; Yeh, Chau-Ting
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-06, Vol.24 (13), p.10668
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Neonatal mortality and outcome at the end of the first year of life in early onset urea cycle disorders—review and meta-analysis of observational studies published over more than 35 years
Author / Creator:Burgard, Peter ; Kölker, Stefan ; Haege, Gisela ; Lindner, Martin ; Hoffmann, Georg F.
Publisher:Dordrecht: Springer Netherlands
Journal title:Journal of inherited metabolic disease, 2016-03, Vol.39 (2), p.219-229
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Age at disease onset and peak ammonium level rather than interventional variables predict the neurological outcome in urea cycle disorders
Author / Creator:Posset, Roland ; Garcia-Cazorla, Angeles ; Valayannopoulos, Vassili ; Teles, Elisa Leão ; Dionisi-Vici, Carlo ; Brassier, Anaïs ; Burlina, Alberto B. ; Burgard, Peter ; Cortès-Saladelafont, Elisenda ; Dobbelaere, Dries ; Couce, Maria L. ; Sykut-Cegielska, Jolanta ; Häberle, Johannes ; Lund, Allan M. ; Chakrapani, Anupam ; Schiff, Manuel ; Walter, John H. ; Zeman, Jiri ; Vara, Roshni ; Kölker, Stefan
Publisher:Dordrecht: Springer Netherlands
Journal title:Journal of inherited metabolic disease, 2016-09, Vol.39 (5), p.661-672
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Gene Therapy in Combination with Nitrogen Scavenger Pretreatment Corrects Biochemical and Behavioral Abnormalities of Infant Citrullinemia Type 1 Mice
Author / Creator:Bazo, Andrea ; Lantero, Aquilino ; Mauleón, Itsaso ; Neri, Leire ; Poms, Martin ; Häberle, Johannes ; Ricobaraza, Ana ; Bénichou, Bernard ; Combal, Jean-Philippe ; Gonzalez-Aseguinolaza, Gloria ; Aldabe, Rafael
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-11, Vol.23 (23), p.14940
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ArticlesPeer ReviewedFull Text
Putrescine production by engineered Corynebacterium glutamicum
Author / Creator:Schneider, Jens ; Wendisch, Volker F
Publisher:Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Journal title:Applied microbiology and biotechnology, 2010-10, Vol.88 (4), p.859-868
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A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas
Author / Creator:Bean, Gregory R ; Kremer, Jeff C ; Prudner, Bethany C ; Schenone, Aaron D ; Yao, Juo-Chin ; Schultze, Matthew B ; Chen, David Y ; Tanas, Munir R ; Adkins, Douglas R ; Bomalaski, John ; Rubin, Brian P ; Michel, Loren S ; Van Tine, Brian A
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2016-10, Vol.7 (10), p.e2406-e2406
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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells
Author / Creator:Khoury, Oula ; Ghazale, Noura ; Stone, Everett ; El-Sibai, Mirvat ; Frankel, Arthur E. ; Abi-Habib, Ralph J.
Publisher:Boston: Springer US
Journal title:Journal of neuro-oncology, 2015-03, Vol.122 (1), p.75-85
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Macrophage fumarate hydratase restrains mtRNA-mediated interferon production

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Arginine dependence of tumor cells: targeting a chink in cancer’s armor

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Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

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FOXO3a-regulated arginine metabolic plasticity adaptively promotes esophageal cancer proliferation and metastasis

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Arginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy

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Bench-to-Bedside Studies of Arginine Deprivation in Cancer

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Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

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Hepatic urea, creatinine and uric acid metabolism in dairy cows with divergent milk urea concentrations

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Requirement of argininosuccinate lyase for systemic nitric oxide production

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Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma

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Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma

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Citrulline metabolism in plants

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Sensitivity of Colorectal Cancer to Arginine Deprivation Therapy is Shaped by Differential Expression of Urea Cycle Enzymes

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Unlocking the Potential of Arginine Deprivation Therapy: Recent Breakthroughs and Promising Future for Cancer Treatment

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Neonatal mortality and outcome at the end of the first year of life in early onset urea cycle disorders—review and meta-analysis of observational studies published over more than 35 years

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Age at disease onset and peak ammonium level rather than interventional variables predict the neurological outcome in urea cycle disorders

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Gene Therapy in Combination with Nitrogen Scavenger Pretreatment Corrects Biochemical and Behavioral Abnormalities of Infant Citrullinemia Type 1 Mice

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Putrescine production by engineered Corynebacterium glutamicum

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A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas

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Human recombinant arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-induced arginine depletion is selectively cytotoxic to human glioblastoma cells

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