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ArticlesPeer ReviewedFull Text
DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas
Author / Creator:He, Yonghan ; Koch, Raphael ; Budamagunta, Vivekananda ; Zhang, Peiyi ; Zhang, Xuan ; Khan, Sajid ; Thummuri, Dinesh ; Ortiz, Yuma T. ; Zhang, Xin ; Lv, Dongwen ; Wiegand, Janet S. ; Li, Wen ; Palmer, Adam C. ; Zheng, Guangrong ; Weinstock, David M. ; Zhou, Daohong
Publisher:England: BioMed Central Ltd
Journal title:Journal of hematology and oncology, 2020-07, Vol.13 (1), p.95-13, Article 95
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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Author / Creator:Khan, Sajid ; Zhang, Xuan ; Lv, Dongwen ; Zhang, Qi ; He, Yonghan ; Zhang, Peiyi ; Liu, Xingui ; Thummuri, Dinesh ; Yuan, Yaxia ; Wiegand, Janet S. ; Pei, Jing ; Zhang, Weizhou ; Sharma, Abhisheak ; McCurdy, Christopher R. ; Kuruvilla, Vinitha M. ; Baran, Natalia ; Ferrando, Adolfo A. ; Kim, Yong-mi ; Rogojina, Anna ; Houghton, Peter J. ; Huang, Guangcun ; Hromas, Robert ; Konopleva, Marina ; Zheng, Guangrong ; Zhou, Daohong
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-12, Vol.25 (12), p.1938-1947
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Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity
Author / Creator:Park, Han-A ; Licznerski, Pawel ; Mnatsakanyan, Nelli ; Niu, Yulong ; Sacchetti, Silvio ; Wu, Jing ; Polster, Brian M ; Alavian, Kambiz N ; Jonas, Elizabeth A
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2017-11, Vol.24 (11), p.1963-1974
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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
Author / Creator:Yosef, Reut ; Pilpel, Noam ; Tokarsky-Amiel, Ronit ; Biran, Anat ; Ovadya, Yossi ; Cohen, Snir ; Vadai, Ezra ; Dassa, Liat ; Shahar, Elisheva ; Condiotti, Reba ; Ben-Porath, Ittai ; Krizhanovsky, Valery
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-04, Vol.7 (1), p.11190-11190, Article 11190
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Structure-guided design of a selective BCL-XL inhibitor
Author / Creator:Lessene, Guillaume ; Czabotar, Peter E ; Sleebs, Brad E ; Zobel, Kerry ; Lowes, Kym N ; Adams, Jerry M ; Baell, Jonathan B ; Colman, Peter M ; Deshayes, Kurt ; Fairbrother, Wayne J ; Flygare, John A ; Gibbons, Paul ; Kersten, Wilhelmus J A ; Kulasegaram, Sanji ; Moss, Rebecca M ; Parisot, John P ; Smith, Brian J ; Street, Ian P ; Yang, Hong ; Huang, David C S ; Watson, Keith G
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2013-06, Vol.9 (6), p.390-397
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer
Author / Creator:Lopez, Andrea ; Reyna, Denis E. ; Gitego, Nadege ; Kopp, Felix ; Zhou, Hua ; Miranda-Roman, Miguel A. ; Nordstrøm, Lars Ulrik ; Narayanagari, Swathi-Rao ; Chi, Ping ; Vilar, Eduardo ; Tsirigos, Aristotelis ; Gavathiotis, Evripidis
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-03, Vol.13 (1), p.1199-1199, Article 1199
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The Structural Biology of Bcl-xL
Author / Creator:Lee, Erinna F. ; Fairlie, W. Douglas
Publisher:Basel: MDPI AG
Journal title:International journal of molecular sciences, 2019-05, Vol.20 (9), p.2234
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Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL
Author / Creator:Haselager, Marco ; Thijssen, Rachel ; West, Christopher ; Young, Louise ; Van Kampen, Roel ; Willmore, Elaine ; Mackay, Simon ; Kater, Arnon ; Eldering, Eric
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2021-05, Vol.28 (5), p.1658-1668
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity
Author / Creator:Lv, Dongwen ; Pal, Pratik ; Liu, Xingui ; Jia, Yannan ; Thummuri, Dinesh ; Zhang, Peiyi ; Hu, Wanyi ; Pei, Jing ; Zhang, Qi ; Zhou, Shuo ; Khan, Sajid ; Zhang, Xuan ; Hua, Nan ; Yang, Qingping ; Arango, Sebastian ; Zhang, Weizhou ; Nayak, Digant ; Olsen, Shaun K. ; Weintraub, Susan T. ; Hromas, Robert ; Konopleva, Marina ; Yuan, Yaxia ; Zheng, Guangrong ; Zhou, Daohong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6896-6896, Article 6896
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Bcl-xL: A Focus on Melanoma Pathobiology
Author / Creator:Lucianò, Anna Maria ; Pérez-Oliva, Ana B. ; Mulero, Victoriano ; Del Bufalo, Donatella
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2021-03, Vol.22 (5), p.2777
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Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL
Author / Creator:Luo, S ; Rubinsztein, D C
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2010-02, Vol.17 (2), p.268-277
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Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1
Author / Creator:Maiuri, M Chiara ; Le Toumelin, Gaëtane ; Criollo, Alfredo ; Rain, Jean-Christophe ; Gautier, Fabien ; Juin, Philippe ; Tasdemir, Ezgi ; Pierron, Gérard ; Troulinaki, Kostoula ; Tavernarakis, Nektarios ; Hickman, John A ; Geneste, Olivier ; Kroemer, Guido
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2007-05, Vol.26 (10), p.2527-2539
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Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate
Author / Creator:Ma, Kaili ; Zhang, Zhi ; Chang, Rui ; Cheng, Hongcheng ; Mu, Chenglong ; Zhao, Tian ; Chen, Linbo ; Zhang, Chuanmei ; Luo, Qian ; Lin, Jialing ; Zhu, Yushan ; Chen, Quan
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2020-03, Vol.27 (3), p.1036-1051
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Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Author / Creator:Rosa, Nicolas ; Ivanova, Hristina ; Wagner, Larry E. ; Kale, Justin ; La Rovere, Rita ; Welkenhuyzen, Kirsten ; Louros, Nikolaos ; Karamanou, Spyridoula ; Shabardina, Victoria ; Lemmens, Irma ; Vandermarliere, Elien ; Hamada, Kozo ; Ando, Hideaki ; Rousseau, Frederic ; Schymkowitz, Joost ; Tavernier, Jan ; Mikoshiba, Katsuhiko ; Economou, Anastassios ; Andrews, David W. ; Parys, Jan B. ; Yule, David I. ; Bultynck, Geert
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2022-04, Vol.29 (4), p.788-805
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BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis
Author / Creator:Huang, Kai ; O’Neill, Katelyn L. ; Li, Jian ; Zhou, Wei ; Han, Na ; Pang, Xiaming ; Wu, Wei ; Struble, Lucas ; Borgstahl, Gloria ; Liu, Zhaorui ; Zhang, Liqiang ; Luo, Xu
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2019-11, Vol.29 (11), p.942-952
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Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis
Author / Creator:Jaiswal, Arunima ; Jaiswal, Aruna ; Williamson, Elizabeth A. ; Gelfond, Jonathon ; Zheng, Guangrong ; Zhou, Daohong ; Hromas, Robert
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer chemotherapy and pharmacology, 2023-01, Vol.91 (1), p.89-95
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Roles and Regulation of BCL-xL in Hematological Malignancies
Author / Creator:Morales-Martínez, Mario ; Vega, Mario I.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-02, Vol.23 (4), p.2193
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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction
Author / Creator:Saleh, Tareq ; Carpenter, Valerie J. ; Tyutyunyk‐Massey, Liliya ; Murray, Graeme ; Leverson, Joel D. ; Souers, Andrew J. ; Alotaibi, Moureq R. ; Faber, Anthony C. ; Reed, Jason ; Harada, Hisashi ; Gewirtz, David A.
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2020-10, Vol.14 (10), p.2504-2519
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Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition
Author / Creator:Nguyen, Trang Thi Thu ; Ishida, Chiaki Tsuge ; Shang, Enyuan ; Shu, Chang ; Torrini, Consuelo ; Zhang, Yiru ; Bianchetti, Elena ; Sanchez‐Quintero, Maria J ; Kleiner, Giulio ; Quinzii, Catarina M ; Westhoff, Mike‐Andrew ; Karpel‐Massler, Georg ; Canoll, Peter ; Siegelin, Markus D
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2019-10, Vol.11 (10), p.e10769-n/a
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JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL
Author / Creator:Haselager, Marco V. ; Thijssen, Rachel ; Bax, Danique ; Both, Demi ; De Boer, Francien ; Mackay, Simon ; Dubois, Julie ; Mellink, Clemens ; Kater, Arnon P. ; Eldering, Eric
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2023-06, Vol.17 (6), p.1112-1128
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Showing 1 to 20 of 5,826 results

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DT2216—a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas

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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

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Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

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Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

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Structure-guided design of a selective BCL-XL inhibitor

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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer

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The Structural Biology of Bcl-xL

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Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL

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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity

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Bcl-xL: A Focus on Melanoma Pathobiology

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Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

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Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1

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Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate

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Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

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BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

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Resistance to the BCL-XL degrader DT2216 in T-cell acute lymphoblastic leukemia is rare and correlates with decreased BCL-XL proteolysis

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Roles and Regulation of BCL-xL in Hematological Malignancies

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Clearance of therapy‐induced senescent tumor cells by the senolytic ABT‐263 via interference with BCL‐XL–BAX interaction

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Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition

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JAK–STAT signalling shapes the NF‐κB response in CLL towards venetoclax sensitivity or resistance via Bcl‐XL

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