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ArticlesPeer ReviewedFull Text
ATP13A2 deficiency disrupts lysosomal polyamine export
Author / Creator:van Veen, Sarah ; Martin, Shaun ; Van den Haute, Chris ; Benoy, Veronick ; Lyons, Joseph ; Vanhoutte, Roeland ; Kahler, Jan Pascal ; Decuypere, Jean-Paul ; Gelders, Géraldine ; Lambie, Eric ; Zielich, Jeffrey ; Swinnen, Johannes V. ; Annaert, Wim ; Agostinis, Patrizia ; Ghesquière, Bart ; Verhelst, Steven ; Baekelandt, Veerle ; Eggermont, Jan ; Vangheluwe, Peter
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-02, Vol.578 (7795), p.419-424
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Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways
Author / Creator:Xie, Zhen ; Zhao, Mengyuan ; Yan, Chengxiang ; Kong, Wei ; Lan, Fei ; Narengaowa ; Zhao, Shuxuan ; Yang, Qinghu ; Bai, Zhantao ; Qing, Hong ; Ni, Junjun
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2023-04, Vol.14 (4), p.255-255, Article 255
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A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer
Author / Creator:Li, Fangfei ; Lu, Jun ; Liu, Jin ; Liang, Chao ; Wang, Maolin ; Wang, Luyao ; Li, Defang ; Yao, Houzong ; Zhang, Qiulong ; Wen, Jia ; Zhang, Zong-Kang ; Li, Jie ; Lv, Quanxia ; He, Xiaojuan ; Guo, Baosheng ; Guan, Daogang ; Yu, Yuanyuan ; Dang, Lei ; Wu, Xiaohao ; Li, Yongshu ; Chen, Guofen ; Jiang, Feng ; Sun, Shiguo ; Zhang, Bao-Ting ; Lu, Aiping ; Zhang, Ge
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-11, Vol.8 (1), p.1390-14, Article 1390
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Cysteine cathepsins are essential in lysosomal degradation of α-synuclein
Author / Creator:McGlinchey, Ryan P. ; Lee, Jennifer C.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (30), p.9322-9327
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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth
Author / Creator:Bruchard, Mélanie ; Mignot, Grégoire ; Derangère, Valentin ; Chalmin, Fanny ; Chevriaux, Angélique ; Végran, Frédérique ; Boireau, Wilfrid ; Simon, Benoit ; Ryffel, Bernhard ; Connat, Jean Louis ; Kanellopoulos, Jean ; Martin, François ; Rébé, Cédric ; Apetoh, Lionel ; Ghiringhelli, François
Publisher:New York: Nature Publishing Group US
Journal title:Nature Medicine, 2013-01, Vol.19 (1), p.57-64
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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Author / Creator:Duewell, Peter ; Kono, Hajime ; Rayner, Katey J. ; Sirois, Cherilyn M. ; Vladimer, Gregory ; Bauernfeind, Franz G. ; Abela, George S. ; Franchi, Luigi ; Nuñez, Gabriel ; Schnurr, Max ; Espevik, Terje ; Lien, Egil ; Fitzgerald, Katherine A. ; Rock, Kenneth L. ; Moore, Kathryn J. ; Wright, Samuel D. ; Hornung, Veit ; Latz, Eicke
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-04, Vol.464 (7293), p.1357-1361
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Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation
Author / Creator:Tang, Tao-Tao ; Lv, Lin-Li ; Pan, Ming-Ming ; Wen, Yi ; Wang, Bin ; Li, Zuo-Lin ; Wu, Min ; Wang, Feng-Mei ; Crowley, Steve D ; Liu, Bi-Cheng
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2018-03, Vol.9 (3), p.351-14, Article 351
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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
Author / Creator:Rajamäki, Kristiina ; Lappalainen, Jani ; Oörni, Katariina ; Välimäki, Elina ; Matikainen, Sampsa ; Kovanen, Petri T ; Eklund, Kari K
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-07, Vol.5 (7), p.e11765-e11765
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B cell zone reticular cell microenvironments shape CXCL13 gradient formation
Author / Creator:Cosgrove, Jason ; Novkovic, Mario ; Albrecht, Stefan ; Pikor, Natalia B. ; Zhou, Zhaoukun ; Onder, Lucas ; Mörbe, Urs ; Cupovic, Jovana ; Miller, Helen ; Alden, Kieran ; Thuery, Anne ; O’Toole, Peter ; Pinter, Rita ; Jarrett, Simon ; Taylor, Emily ; Venetz, Daniel ; Heller, Manfred ; Uguccioni, Mariagrazia ; Legler, Daniel F. ; Lacey, Charles J. ; Coatesworth, Andrew ; Polak, Wojciech G. ; Cupedo, Tom ; Manoury, Bénedicte ; Thelen, Marcus ; Stein, Jens V. ; Wolf, Marlene ; Leake, Mark C. ; Timmis, Jon ; Ludewig, Burkhard ; Coles, Mark C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3677-3677, Article 3677
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ArticlesPeer ReviewedFull Text
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Author / Creator:Hämälistö, Saara ; Stahl, Jonathan Lucien ; Favaro, Elena ; Yang, Qing ; Liu, Bin ; Christoffersen, Line ; Loos, Ben ; Guasch Boldú, Claudia ; Joyce, Johanna A. ; Reinheckel, Thomas ; Barisic, Marin ; Jäättelä, Marja
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.229-229, Article 229
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ArticlesPeer ReviewedFull Text
Stat3 controls lysosomal-mediated cell death in vivo
Author / Creator:Kreuzaler, Peter A. ; Staniszewska, Anna D. ; Li, Wenjing ; Omidvar, Nader ; Kedjouar, Blandine ; Turkson, James ; Poli, Valeria ; Flavell, Richard A. ; Clarkson, Richard W. E. ; Watson, Christine J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2011-03, Vol.13 (3), p.303-309
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cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1
Author / Creator:Gamdzyk, Marcin ; Doycheva, Desislava Met ; Araujo, Camila ; Ocak, Umut ; Luo, Yujie ; Tang, Jiping ; Zhang, John H.
Publisher:New York: Springer US
Journal title:Molecular neurobiology, 2020-06, Vol.57 (6), p.2600-2619
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CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas
Author / Creator:Ma, Kaiming ; Chen, Xin ; Liu, Weihai ; Chen, Suhua ; Yang, Chenlong ; Yang, Jun
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-03, Vol.12 (1), p.4295-4295, Article 4295
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ArticlesPeer ReviewedFull Text
Eradication of unresectable liver metastasis through induction of tumour specific energy depletion
Author / Creator:Huo, Da ; Zhu, Jianfeng ; Chen, Guojun ; Chen, Qian ; Zhang, Chao ; Luo, Xingyu ; Jiang, Wei ; Jiang, Xiqun ; Gu, Zhen ; Hu, Yong
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-07, Vol.10 (1), p.3051-17, Article 3051
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ArticlesPeer ReviewedFull Text
High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
Author / Creator:Gabandé-Rodríguez, E ; Boya, P ; Labrador, V ; Dotti, C G ; Ledesma, M D
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2014-06, Vol.21 (6), p.864-875
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ArticlesPeer ReviewedFull Text
Molecular Mechanism of NLRP3 Inflammasome Activation
Author / Creator:Jin, Chengcheng ; Flavell, Richard A
Publisher:Boston: Boston : Springer US
Journal title:Journal of clinical immunology, 2010-09, Vol.30 (5), p.628-631
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Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice
Author / Creator:Sendler, Matthias ; Dummer, Annegret ; Weiss, Frank U ; Krüger, Burkhard ; Wartmann, Thomas ; Scharffetter-Kochanek, Karin ; van Rooijen, Nico ; Malla, Sudarshan Ravi ; Aghdassi, Ali ; Halangk, Walter ; Lerch, Markus M ; Mayerle, Julia
Publisher:England: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2013-03, Vol.62 (3), p.430-439
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ArticlesPeer ReviewedFull Text
Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction
Author / Creator:Aufy, Mohammed ; Abdelaziz, Ramadan F ; Hussein, Ahmed M ; Topcagic, Nermina ; Shamroukh, Hadil ; Abdel-Maksoud, Mostafa A ; Salem, Tamer Z ; Studenik, Christian R
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-01, Vol.24 (3), p.2030
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FICD activity and AMPylation remodelling modulate human neurogenesis
Author / Creator:Kielkowski, Pavel ; Buchsbaum, Isabel Y. ; Kirsch, Volker C. ; Bach, Nina C. ; Drukker, Micha ; Cappello, Silvia ; Sieber, Stephan A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.517-517, Article 517
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Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins
Author / Creator:Cermak, Stjepko ; Kosicek, Marko ; Mladenovic-Djordjevic, Aleksandra ; Smiljanic, Kosara ; Kanazir, Selma ; Hecimovic, Silva
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-11, Vol.11 (11), p.e0167428-e0167428
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ATP13A2 deficiency disrupts lysosomal polyamine export

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Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

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A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

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Cysteine cathepsins are essential in lysosomal degradation of α-synuclein

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Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

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NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

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Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation

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Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation

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B cell zone reticular cell microenvironments shape CXCL13 gradient formation

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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

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Stat3 controls lysosomal-mediated cell death in vivo

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cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1

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CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas

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Eradication of unresectable liver metastasis through induction of tumour specific energy depletion

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High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A

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Molecular Mechanism of NLRP3 Inflammasome Activation

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Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice

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Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction

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FICD activity and AMPylation remodelling modulate human neurogenesis

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Loss of Cathepsin B and L Leads to Lysosomal Dysfunction, NPC-Like Cholesterol Sequestration and Accumulation of the Key Alzheimer's Proteins

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