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ArticlesPeer ReviewedFull Text
Disruption of mitochondrial complex I induces progressive parkinsonism
Author / Creator:González-Rodríguez, Patricia ; Zampese, Enrico ; Stout, Kristen A. ; Guzman, Jaime N. ; Ilijic, Ema ; Yang, Ben ; Tkatch, Tatiana ; Stavarache, Mihaela A. ; Wokosin, David L. ; Gao, Lin ; Kaplitt, Michael G. ; López-Barneo, José ; Schumacker, Paul T. ; Surmeier, D. James
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-11, Vol.599 (7886), p.650-656
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Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease
Author / Creator:Marogianni, Chrysoula ; Sokratous, Maria ; Dardiotis, Efthimios ; Hadjigeorgiou, Georgios M ; Bogdanos, Dimitrios ; Xiromerisiou, Georgia
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2020-11, Vol.21 (22), p.8421
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Parkinson's Disease: From Pathogenesis to Pharmacogenomics
Author / Creator:Cacabelos, Ramón
Publisher:Switzerland: MDPI
Journal title:International journal of molecular sciences, 2017-03, Vol.18 (3), p.551-551
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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease
Author / Creator:Kam, Tae-In ; Mao, Xiaobo ; Park, Hyejin ; Chou, Shih-Ching ; Karuppagounder, Senthilkumar S ; Umanah, George Essien ; Yun, Seung Pil ; Brahmachari, Saurav ; Panicker, Nikhil ; Chen, Rong ; Andrabi, Shaida A ; Qi, Chen ; Poirier, Guy G ; Pletnikova, Olga ; Troncoso, Juan C ; Bekris, Lynn M ; Leverenz, James B ; Pantelyat, Alexander ; Ko, Han Seok ; Rosenthal, Liana S ; Dawson, Ted M ; Dawson, Valina L
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6414)
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Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice
Author / Creator:Matheoud, Diana ; Cannon, Tyler ; Voisin, Aurore ; Penttinen, Anna-Maija ; Ramet, Lauriane ; Fahmy, Ahmed M. ; Ducrot, Charles ; Laplante, Annie ; Bourque, Marie-Josée ; Zhu, Lei ; Cayrol, Romain ; Le Campion, Armelle ; McBride, Heidi M. ; Gruenheid, Samantha ; Trudeau, Louis-Eric ; Desjardins, Michel
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-07, Vol.571 (7766), p.565-569
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What do patients with scans without evidence of dopaminergic deficit (SWEDD) have? New evidence and continuing controversies
Author / Creator:Erro, Roberto ; Schneider, Susanne A ; Stamelou, Maria ; Quinn, Niall P ; Bhatia, Kailash P
Publisher:England: BMJ Publishing Group LTD
Journal title:Journal of neurology, neurosurgery and psychiatry, 2016-03, Vol.87 (3), p.319-323
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Initiation and propagation of α-synuclein aggregation in the nervous system
Author / Creator:Hijaz, Baraa A ; Volpicelli-Daley, Laura A
Publisher:England: BioMed Central
Journal title:Molecular neurodegeneration, 2020-03, Vol.15 (1), p.19-19, Article 19
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Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
Author / Creator:Nobili, Annalisa ; Latagliata, Emanuele Claudio ; Viscomi, Maria Teresa ; Cavallucci, Virve ; Cutuli, Debora ; Giacovazzo, Giacomo ; Krashia, Paraskevi ; Rizzo, Francesca Romana ; Marino, Ramona ; Federici, Mauro ; De Bartolo, Paola ; Aversa, Daniela ; Dell’Acqua, Maria Concetta ; Cordella, Alberto ; Sancandi, Marco ; Keller, Flavio ; Petrosini, Laura ; Puglisi-Allegra, Stefano ; Mercuri, Nicola Biagio ; Coccurello, Roberto ; Berretta, Nicola ; D’Amelio, Marcello
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-04, Vol.8 (1), p.14727-14727, Article 14727
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Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration
Author / Creator:Mor, Danielle E ; Tsika, Elpida ; Mazzulli, Joseph R ; Gould, Neal S ; Kim, Hanna ; Daniels, Malcolm J ; Doshi, Shachee ; Gupta, Preetika ; Grossman, Jennifer L ; Tan, Victor X ; Kalb, Robert G ; Caldwell, Kim A ; Caldwell, Guy A ; Wolfe, John H ; Ischiropoulos, Harry
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2017-11, Vol.20 (11), p.1560-1568
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ArticlesPeer ReviewedFull Text
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Author / Creator:Luk, Kelvin C. ; Kehm, Victoria ; Carroll, Jenna ; Zhang, Bin ; O'Brien, Patrick ; Trojanowski, John Q. ; Lee, Virginia M.-Y.
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2012-11, Vol.338 (6109), p.949-953
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ArticlesPeer ReviewedFull Text
The immunology of Parkinson’s disease
Author / Creator:Zhu, Biqing ; Yin, Dominic ; Zhao, Hongyu ; Zhang, Le
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Seminars in immunopathology, 2022-09, Vol.44 (5), p.659-672
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Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
Author / Creator:Bido, Simone ; Muggeo, Sharon ; Massimino, Luca ; Marzi, Matteo Jacopo ; Giannelli, Serena Gea ; Melacini, Elena ; Nannoni, Melania ; Gambarè, Diana ; Bellini, Edoardo ; Ordazzo, Gabriele ; Rossi, Greta ; Maffezzini, Camilla ; Iannelli, Angelo ; Luoni, Mirko ; Bacigaluppi, Marco ; Gregori, Silvia ; Nicassio, Francesco ; Broccoli, Vania
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6237-15, Article 6237
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ArticlesPeer ReviewedFull Text
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
Author / Creator:Thakur, Poonam ; Breger, Ludivine S. ; Lundblad, Martin ; Wan, Oi Wan ; Mattsson, Bengt ; Luk, Kelvin C. ; Lee, Virginia M. Y. ; Trojanowski, John Q. ; Björklund, Anders
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-09, Vol.114 (39), p.E8284-E8293
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ArticlesPeer ReviewedFull Text
Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons
Author / Creator:Pujols, Jordi ; Peña-Díaz, Samuel ; Lázaro, Diana F. ; Peccati, Francesca ; Pinheiro, Francisca ; González, Danilo ; Carija, Anita ; Navarro, Susanna ; Conde-Giménez, María ; García, Jesús ; Guardiola, Salvador ; Giralt, Ernest ; Salvatella, Xavier ; Sancho, Javier ; Sodupe, Mariona ; Outeiro, Tiago Fleming ; Dalfó, Esther ; Ventura, Salvador
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (41), p.10481-10486
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ArticlesPeer ReviewedFull Text
TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation
Author / Creator:Jinn, Sarah ; Drolet, Robert E. ; Cramer, Paige E. ; Wong, Andus Hon-Kit ; Toolan, Dawn M. ; Gretzula, Cheryl A. ; Voleti, Bhavya ; Vassileva, Galya ; Disa, Jyoti ; Tadin-Strapps, Marija ; Stone, David J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-02, Vol.114 (9), p.2389-2394
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ArticlesPeer ReviewedFull Text
Metabolic alterations in Parkinson’s disease astrocytes
Author / Creator:Sonninen, Tuuli-Maria ; Hämäläinen, Riikka H. ; Koskuvi, Marja ; Oksanen, Minna ; Shakirzyanova, Anastasia ; Wojciechowski, Sara ; Puttonen, Katja ; Naumenko, Nikolay ; Goldsteins, Gundars ; Laham-Karam, Nihay ; Lehtonen, Marko ; Tavi, Pasi ; Koistinaho, Jari ; Lehtonen, Šárka
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-09, Vol.10 (1), p.14474-14474, Article 14474
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LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease
Author / Creator:Nguyen, Maria ; Krainc, Dimitri
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (21), p.5576-5581
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Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance
Author / Creator:Brekk, Oeystein Roed ; Honey, Jonathan R. ; Lee, Seungil ; Hallett, Penelope J. ; Isacson, Ole
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-11, Vol.117 (44), p.27646-27654
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Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model
Author / Creator:Wegrzynowicz, Michal ; Bar-On, Dana ; Calo’, Laura ; Anichtchik, Oleg ; Iovino, Mariangela ; Xia, Jing ; Ryazanov, Sergey ; Leonov, Andrei ; Giese, Armin ; Dalley, Jeffrey W. ; Griesinger, Christian ; Ashery, Uri ; Spillantini, Maria Grazia
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2019-10, Vol.138 (4), p.575-595
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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
Author / Creator:Janezic, Stephanie ; Threlfell, Sarah ; Dodson, Paul D ; Dowie, Megan J ; Taylor, Tonya N ; Potgieter, Dawid ; Parkkinen, Laura ; Senior, Steven L ; Anwar, Sabina ; Ryan, Brent ; Deltheil, Thierry ; Kosillo, Polina ; Cioroch, Milena ; Wagner, Katharina ; Ansorge, Olaf ; Bannerman, David M ; Bolam, J Paul ; Magill, Peter J ; Cragg, Stephanie J ; Wade-Martins, Richard
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-10, Vol.110 (42), p.E4016-E4025
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Showing 1 to 20 of 585 results

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Disruption of mitochondrial complex I induces progressive parkinsonism

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Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disease

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Parkinson's Disease: From Pathogenesis to Pharmacogenomics

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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease

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Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

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What do patients with scans without evidence of dopaminergic deficit (SWEDD) have? New evidence and continuing controversies

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Initiation and propagation of α-synuclein aggregation in the nervous system

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Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease

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Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration

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Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

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The immunology of Parkinson’s disease

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Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity

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Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

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Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons

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TMEM175 deficiency impairs lysosomal and mitochondrial function and increases α-synuclein aggregation

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Metabolic alterations in Parkinson’s disease astrocytes

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LRRK2 phosphorylation of auxilin mediates synaptic defects in dopaminergic neurons from patients with Parkinson’s disease

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Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance

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Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model

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Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model

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