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ArticlesPeer ReviewedFull Text
Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation
Author / Creator:Miki, Atsushi ; Ricordi, Camillo ; Sakuma, Yasunaru ; Yamamoto, Toshiyuki ; Misawa, Ryosuke ; Mita, Atsuyoshi ; Molano, Ruth D ; Vaziri, Nosratola D ; Pileggi, Antonello ; Ichii, Hirohito
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-05, Vol.13 (5), p.e0196570-e0196570
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The liver-alpha cell axis and type 2 diabetes
Author / Creator:Wewer Albrechtsen, Nicolai J ; Pedersen, Jens ; Galsgaard, Katrine D ; Winther-Sørensen, Marie ; Suppli, Malte P ; Janah, Lina ; Gromada, Jesper ; Vilstrup, Hendrik ; Knop, Filip K ; Holst, Jens J
Publisher:United States: Copyright Oxford University Press
Journal title:Endocrine reviews, 2019-10, Vol.40 (5), p.1353-1366
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Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases
Author / Creator:Hædersdal, Sofie ; Andersen, Andreas ; Knop, Filip K. ; Vilsbøll, Tina
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2023-06, Vol.19 (6), p.321-335
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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion
Author / Creator:Bonner, Caroline ; Kerr-Conte, Julie ; Gmyr, Valéry ; Queniat, Gurvan ; Moerman, Ericka ; Thévenet, Julien ; Beaucamps, Cédric ; Delalleau, Nathalie ; Popescu, Iuliana ; Malaisse, Willy J ; Sener, Abdullah ; Deprez, Benoit ; Abderrahmani, Amar ; Staels, Bart ; Pattou, François
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-05, Vol.21 (5), p.512-517
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High residual C-peptide likely contributes to glycemic control in type 1 diabetes
Author / Creator:Rickels, Michael R ; Evans-Molina, Carmella ; Bahnson, Henry T ; Ylescupidez, Alyssa ; Nadeau, Kristen J ; Hao, Wei ; Clements, Mark A ; Sherr, Jennifer L ; Pratley, Richard E ; Hannon, Tamara S ; Shah, Viral N ; Miller, Kellee M ; Greenbaum, Carla J
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-04, Vol.130 (4), p.1850-1862
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Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Author / Creator:Furuyama, Kenichiro ; Chera, Simona ; van Gurp, Léon ; Oropeza, Daniel ; Ghila, Luiza ; Damond, Nicolas ; Vethe, Heidrun ; Paulo, Joao A. ; Joosten, Antoinette M. ; Berney, Thierry ; Bosco, Domenico ; Dorrell, Craig ; Grompe, Markus ; Ræder, Helge ; Roep, Bart O. ; Thorel, Fabrizio ; Herrera, Pedro L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-03, Vol.567 (7746), p.43-48
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Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
Author / Creator:Chera, Simona ; Baronnier, Delphine ; Ghila, Luiza ; Cigliola, Valentina ; Jensen, Jan N. ; Gu, Guoqiang ; Furuyama, Kenichiro ; Thorel, Fabrizio ; Gribble, Fiona M. ; Reimann, Frank ; Herrera, Pedro L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-10, Vol.514 (7523), p.503-507
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Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets
Author / Creator:Adriaenssens, Alice E. ; Svendsen, Berit ; Lam, Brian Y. H. ; Yeo, Giles S. H. ; Holst, Jens J. ; Reimann, Frank ; Gribble, Fiona M.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2016-10, Vol.59 (10), p.2156-2165
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ArticlesPeer ReviewedFull Text
Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
Author / Creator:Chiou, Joshua ; Zeng, Chun ; Cheng, Zhang ; Han, Jee Yun ; Schlichting, Michael ; Miller, Michael ; Mendez, Robert ; Huang, Serina ; Wang, Jinzhao ; Sui, Yinghui ; Deogaygay, Allison ; Okino, Mei-Lin ; Qiu, Yunjiang ; Sun, Ying ; Kudtarkar, Parul ; Fang, Rongxin ; Preissl, Sebastian ; Sander, Maike ; Gorkin, David U. ; Gaulton, Kyle J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2021-04, Vol.53 (4), p.455-466
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ArticlesPeer ReviewedFull Text
Epigenomic plasticity enables human pancreatic α to β cell reprogramming
Author / Creator:Bramswig, Nuria C ; Everett, Logan J ; Schug, Jonathan ; Dorrell, Craig ; Liu, Chengyang ; Luo, Yanping ; Streeter, Philip R ; Naji, Ali ; Grompe, Markus ; Kaestner, Klaus H
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-03, Vol.123 (3), p.1275-1284
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ArticlesPeer ReviewedFull Text
Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells
Author / Creator:Ellingsgaard, Helga ; Hauselmann, Irina ; Schuler, Beat ; Habib, Abdella M ; Baggio, Laurie L ; Meier, Daniel T ; Eppler, Elisabeth ; Bouzakri, Karim ; Wueest, Stephan ; Muller, Yannick D ; Hansen, Ann Maria Kruse ; Reinecke, Manfred ; Konrad, Daniel ; Gassmann, Max ; Reimann, Frank ; Halban, Philippe A ; Gromada, Jesper ; Drucker, Daniel J ; Gribble, Fiona M ; Ehses, Jan A ; Donath, Marc Y
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2011-11, Vol.17 (11), p.1481-1489
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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets
Author / Creator:Marchetti, P. ; Lupi, R. ; Bugliani, M. ; Kirkpatrick, C. L. ; Sebastiani, G. ; Grieco, F. A. ; Del Guerra, S. ; D’Aleo, V. ; Piro, S. ; Marselli, L. ; Boggi, U. ; Filipponi, F. ; Tinti, L. ; Salvini, L. ; Wollheim, C. B. ; Purrello, F. ; Dotta, F.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Diabetologia, 2012-12, Vol.55 (12), p.3262-3272
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Author / Creator:Omar-Hmeadi, Muhmmad ; Lund, Per-Eric ; Gandasi, Nikhil R. ; Tengholm, Anders ; Barg, Sebastian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-04, Vol.11 (1), p.1896-1896, Article 1896
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Organisation of the human pancreas in health and in diabetes
Author / Creator:Atkinson, Mark A. ; Campbell-Thompson, Martha ; Kusmartseva, Irina ; Kaestner, Klaus H.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2020-10, Vol.63 (10), p.1966-1973
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Repressing miR-23a promotes the transdifferentiation of pancreatic α cells to β cells via negatively regulating the expression of SDF-1α
Author / Creator:Lang, Hongmei ; Lin, Ning ; Chen, Xiaorong ; Xiang, Jie ; Zhang, Xingping ; Kang, Chao
Publisher:United States: Public Library of Science (PLoS)
Journal title:PloS one, 2024, Vol.19 (3), p.e0299821-e0299821
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ArticlesPeer ReviewedFull Text
PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Author / Creator:Swisa, Avital ; Avrahami, Dana ; Eden, Noa ; Zhang, Jia ; Feleke, Eseye ; Dahan, Tehila ; Cohen-Tayar, Yamit ; Stolovich-Rain, Miri ; Kaestner, Klaus H ; Glaser, Benjamin ; Ashery-Padan, Ruth ; Dor, Yuval
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-01, Vol.127 (1), p.230-243
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The α-cell in diabetes mellitus
Author / Creator:Gromada, Jesper ; Chabosseau, Pauline ; Rutter, Guy A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2018-12, Vol.14 (12), p.694-704
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Primary cilia control glucose homeostasis via islet paracrine interactions
Author / Creator:Hughes, Jing W. ; Cho, Jung Hoon ; Conway, Hannah E. ; DiGruccio, Michael R. ; Ng, Xue Wen ; Roseman, Henry F. ; Abreu, Damien ; Urano, Fumihiko ; Piston, David W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (16), p.8912-8923
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Islet α cells and glucagon—critical regulators of energy homeostasis
Author / Creator:Campbell, Jonathan E. ; Drucker, Daniel J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Endocrinology, 2015-06, Vol.11 (6), p.329-338
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Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
Author / Creator:Thorel, Fabrizio ; Népote, Virginie ; Avril, Isabelle ; Kohno, Kenji ; Desgraz, Renaud ; Chera, Simona ; Herrera, Pedro L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2010-04, Vol.464 (7292), p.1149-1154
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Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

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The liver-alpha cell axis and type 2 diabetes

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Revisiting the role of glucagon in health, diabetes mellitus and other metabolic diseases

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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

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High residual C-peptide likely contributes to glycemic control in type 1 diabetes

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Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

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Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers

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Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets

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Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

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Epigenomic plasticity enables human pancreatic α to β cell reprogramming

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets

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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

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Organisation of the human pancreas in health and in diabetes

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Repressing miR-23a promotes the transdifferentiation of pancreatic α cells to β cells via negatively regulating the expression of SDF-1α

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PAX6 maintains β cell identity by repressing genes of alternative islet cell types

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The α-cell in diabetes mellitus

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Primary cilia control glucose homeostasis via islet paracrine interactions

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Islet α cells and glucagon—critical regulators of energy homeostasis

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Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

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