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29 results for Kuhn,+Peer-hendrik

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ArticlesPeer ReviewedFull Text
PERK activation mitigates tau pathology in vitro and in vivo
Author / Creator:Bruch, Julius ; Xu, Hong ; Rösler, Thomas W ; De Andrade, Anderson ; Kuhn, Peer‐Hendrik ; Lichtenthaler, Stefan F ; Arzberger, Thomas ; Winklhofer, Konstanze F ; Müller, Ulrich ; Höglinger, Günter U
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2017-03, Vol.9 (3), p.371-384
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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function
Author / Creator:Kuhn, Peer-Hendrik ; Colombo, Alessio Vittorio ; Schusser, Benjamin ; Dreymueller, Daniela ; Wetzel, Sebastian ; Schepers, Ute ; Herber, Julia ; Ludwig, Andreas ; Kremmer, Elisabeth ; Montag, Dirk ; Müller, Ulrike ; Schweizer, Michaela ; Saftig, Paul ; Bräse, Stefan ; Lichtenthaler, Stefan F
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2016-01, Vol.5
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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease
Author / Creator:Kretner, Benedikt ; Trambauer, Johannes ; Fukumori, Akio ; Mielke, Janina ; Kuhn, Peer‐Hendrik ; Kremmer, Elisabeth ; Giese, Armin ; Lichtenthaler, Stefan F ; Haass, Christian ; Arzberger, Thomas ; Steiner, Harald
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2016-05, Vol.8 (5), p.458-465
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ArticlesPeer ReviewedFull Text
ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons
Author / Creator:Kuhn, Peer-Hendrik ; Wang, Huanhuan ; Dislich, Bastian ; Colombo, Alessio ; Zeitschel, Ulrike ; Ellwart, Joachim W ; Kremmer, Elisabeth ; Roßner, Steffen ; Lichtenthaler, Stefan F
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2010-09, Vol.29 (17), p.3020-3032
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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
Author / Creator:Kuhn, Peer-Hendrik ; Koroniak, Katarzyna ; Hogl, Sebastian ; Colombo, Alessio ; Zeitschel, Ulrike ; Willem, Michael ; Volbracht, Christiane ; Schepers, Ute ; Imhof, Axel ; Hoffmeister, Albrecht ; Haass, Christian ; Roßner, Steffen ; Bräse, Stefan ; Lichtenthaler, Stefan F
Publisher:Chichester, UK: John Wiley & Sons, Ltd
Journal title:The EMBO journal, 2012-07, Vol.31 (14), p.3157-3168
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The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations
Author / Creator:Willvonseder, Barbara ; Stögbauer, Fabian ; Steiger, Katja ; Jesinghaus, Moritz ; Kuhn, Peer-Hendrik ; Brambs, Christine ; Engel, Jutta ; Bronger, Holger ; Schmidt, Georg Philipp ; Haller, Bernhard ; Weichert, Wilko ; Keller, Gisela ; Noske, Aurelia ; Pfarr, Nicole ; Boxberg, Melanie
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cancer Immunology, Immunotherapy, 2021-06, Vol.70 (6), p.1679-1689
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ArticlesPeer ReviewedFull Text
QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
Author / Creator:Yates, Sharon C ; Groeneboom, Nicolaas E ; Coello, Christopher ; Lichtenthaler, Stefan F ; Kuhn, Peer-Hendrik ; Demuth, Hans-Ulrich ; Hartlage-Rübsamen, Maike ; Roßner, Steffen ; Leergaard, Trygve ; Kreshuk, Anna ; Puchades, Maja A ; Bjaalie, Jan G
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroinformatics, 2019-12, Vol.13, p.75-75
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Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
Author / Creator:Pigoni, Martina ; Wanngren, Johanna ; Kuhn, Peer-Hendrik ; Munro, Kathryn M ; Gunnersen, Jenny M ; Takeshima, Hiroshi ; Feederle, Regina ; Voytyuk, Iryna ; De Strooper, Bart ; Levasseur, Mikail D ; Hrupka, Brian J ; Müller, Stephan A ; Lichtenthaler, Stefan F
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2016-10, Vol.11 (1), p.67-67, Article 67
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ArticlesPeer ReviewedFull Text
The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control
Author / Creator:Hadjipanayi, Ektoras ; Kuhn, Peer-Hendrik ; Moog, Philipp ; Bauer, Anna-Theresa ; Kuekrek, Haydar ; Mirzoyan, Lilit ; Hummel, Anja ; Kirchhoff, Katharina ; Salgin, Burak ; Isenburg, Sarah ; Dornseifer, Ulf ; Ninkovic, Milomir ; Machens, Hans-Günther ; Schilling, Arndt F
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-08, Vol.10 (8), p.e0135618-e0135618
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ArticlesPeer ReviewedFull Text
BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains
Author / Creator:Causevic, Mirsada ; Dominko, Kristina ; Malnar, Martina ; Vidatic, Lea ; Cermak, Stjepko ; Pigoni, Martina ; Kuhn, Peer-Hendrik ; Colombo, Alessio ; Havas, Daniel ; Flunkert, Stefanie ; McDonald, Jessica ; Gunnersen, Jenny M ; Hutter-Paier, Birgit ; Tahirovic, Sabina ; Windisch, Manfred ; Krainc, Dimitri ; Lichtenthaler, Stefan F ; Hecimovic, Silva
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-07, Vol.13 (7), p.e0200344-e0200344
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ArticlesPeer ReviewedFull Text
Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase
Author / Creator:Hogl, Sebastian ; Kuhn, Peer-Hendrik ; Colombo, Alessio ; Lichtenthaler, Stefan F
Publisher:United States: Public Library of Science
Journal title:PloS one, 2011, Vol.6 (6), p.e21337
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ArticlesPeer ReviewedFull Text
Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
Author / Creator:Hartlage-Rübsamen, Maike ; Bluhm, Alexandra ; Piechotta, Anke ; Linnert, Miriam ; Rahfeld, Jens-Ulrich ; Demuth, Hans-Ulrich ; Lues, Inge ; Kuhn, Peer-Hendrik ; Lichtenthaler, Stefan F ; Roßner, Steffen ; Höfling, Corinna
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2018-04, Vol.23 (4), p.924
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ArticlesPeer ReviewedFull Text
Cell-to-cell propagation of infectious cytosolic protein aggregates
Author / Creator:Hofmann, Julia P. ; Denner, Philip ; Nussbaum-Krammer, Carmen ; Kuhn, Peer-Hendrik ; Suhre, Michael H. ; Scheibel, Thomas ; Lichtenthaler, Stefan F. ; Schätzl, Hermann M. ; Bano, Daniele ; Vorberg, Ina M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (15), p.5951-5956
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ArticlesPeer ReviewedFull Text
Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10
Author / Creator:Augustin, Regina ; Endres, Kristina ; Reinhardt, Sven ; Kuhn, Peer-Hendrik ; Lichtenthaler, Stefan F ; Hansen, Jens ; Wurst, Wolfgang ; Trümbach, Dietrich
Publisher:England: BioMed Central
Journal title:BMC genetics, 2012-05, Vol.13 (1), p.35-35, Article 35
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ArticlesPeer ReviewedFull Text
Multi-omics analysis to uncover the molecular basis of tumor budding in head and neck squamous cell carcinoma
Author / Creator:Ourailidis, Iordanis ; Stögbauer, Fabian ; Zhou, Yuxiang ; Beck, Susanne ; Romanovsky, Eva ; Eckert, Stephan ; Wollenberg, Barbara ; Wirth, Markus ; Steiger, Katja ; Kuster, Bernhard ; Gires, Olivier ; Stenzinger, Albrecht ; Schirmacher, Peter ; Weichert, Wilko ; Kuhn, Peer-Hendrik ; Boxberg, Melanie ; Budczies, Jan
Publisher:London: Nature Publishing Group UK
Journal title:NPJ precision oncology, 2025-03, Vol.9 (1), p.73-18, Article 73
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Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies
Author / Creator:Höfling, Corinna ; Morawski, Markus ; Zeitschel, Ulrike ; Zanier, Elisa R. ; Moschke, Katrin ; Serdaroglu, Alperen ; Canneva, Fabio ; Hörsten, Stephan ; De Simoni, Maria‐Grazia ; Forloni, Gianluigi ; Jäger, Carsten ; Kremmer, Elisabeth ; Roßner, Steffen ; Lichtenthaler, Stefan F. ; Kuhn, Peer‐Hendrik
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2016-10, Vol.15 (5), p.953-963
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ArticlesPeer ReviewedFull Text
Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease
Author / Creator:Höfling, Corinna ; Shehabi, Emira ; Kuhn, Peer-Hendrik ; Lichtenthaler, Stefan F ; Hartlage-Rübsamen, Maike ; Roßner, Steffen
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2019-02, Vol.13, p.137-137
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Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU
Author / Creator:Lahmer, Tobias ; Weirich, Gregor ; Porubsky, Stefan ; Rasch, Sebastian ; Kammerstetter, Florian A ; Schustetter, Christian ; Schüffler, Peter ; Erber, Johanna ; Dibos, Miriam ; Delbridge, Claire ; Kuhn, Peer Hendrik ; Jeske, Samuel ; Steinhardt, Manuel ; Chaker, Adam ; Heim, Markus ; Heemann, Uwe ; Schmid, Roland M ; Weichert, Wilko ; Stock, Konrad Friedrich ; Slotta-Huspenina, Julia
Publisher:Switzerland: MDPI AG
Journal title:Diagnostics (Basel), 2024-01, Vol.14 (3), p.294
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ArticlesPeer ReviewedFull Text
γ-secretase directly sheds the survival receptor BCMA from plasma cells
Author / Creator:Laurent, Sarah A. ; Hoffmann, Franziska S. ; Kuhn, Peer-Hendrik ; Cheng, Qingyu ; Chu, Yuanyuan ; Schmidt-Supprian, Marc ; Hauck, Stefanie M. ; Schuh, Elisabeth ; Krumbholz, Markus ; Rübsamen, Heike ; Wanngren, Johanna ; Khademi, Mohsen ; Olsson, Tomas ; Alexander, Tobias ; Hiepe, Falk ; Pfister, Hans-Walter ; Weber, Frank ; Jenne, Dieter ; Wekerle, Hartmut ; Hohlfeld, Reinhard ; Lichtenthaler, Stefan F. ; Meinl, Edgar
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-06, Vol.6 (1), p.7333-7333, Article 7333
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ArticlesPeer ReviewedFull Text
Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance
Author / Creator:Boxberg, Melanie ; Bollwein, Christine ; Jöhrens, Korinna ; Kuhn, Peer-Hendrik ; Haller, Bernhard ; Steiger, Katja ; Wolff, Klaus-Dietrich ; Kolk, Andreas ; Jesinghaus, Moritz ; Weichert, Wilko
Publisher:England: BMJ Publishing Group Ltd and Association of Clinical Pathologists
Journal title:Journal of clinical pathology, 2019-04, Vol.72 (4), p.285-294
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Showing 1 to 20 of 29 results

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PERK activation mitigates tau pathology in vitro and in vivo

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Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

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Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

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ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

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Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

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The immunologic tumor microenvironment in endometrioid endometrial cancer in the morphomolecular context: mutual correlations and prognostic impact depending on molecular alterations

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QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain

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Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons

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The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control

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BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains

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Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase

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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation

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Cell-to-cell propagation of infectious cytosolic protein aggregates

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Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

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Multi-omics analysis to uncover the molecular basis of tumor budding in head and neck squamous cell carcinoma

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Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies

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Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease

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Postmortem Minimally Invasive Autopsy in Critically Ill COVID-19 Patients at the Bedside: A Proof-of-Concept Study at the ICU

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γ-secretase directly sheds the survival receptor BCMA from plasma cells

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Novel prognostic histopathological grading system in oral squamous cell carcinoma based on tumour budding and cell nest size shows high interobserver and intraobserver concordance

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