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824 results for NFATC+Transcription+Factors+-+metabolism

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ArticlesPeer ReviewedFull Text
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
Author / Creator:Khan, Omar ; Giles, Josephine R. ; McDonald, Sierra ; Manne, Sasikanth ; Ngiow, Shin Foong ; Patel, Kunal P. ; Werner, Michael T. ; Huang, Alexander C. ; Alexander, Katherine A. ; Wu, Jennifer E. ; Attanasio, John ; Yan, Patrick ; George, Sangeeth M. ; Bengsch, Bertram ; Staupe, Ryan P. ; Donahue, Greg ; Xu, Wei ; Amaravadi, Ravi K. ; Xu, Xiaowei ; Karakousis, Giorgos C. ; Mitchell, Tara C. ; Schuchter, Lynn M. ; Kaye, Jonathan ; Berger, Shelley L. ; Wherry, E. John
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-07, Vol.571 (7764), p.211-218
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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells
Author / Creator:Seo, Hyungseok ; González-Avalos, Edahí ; Zhang, Wade ; Ramchandani, Payal ; Yang, Chao ; Lio, Chan-Wang J. ; Rao, Anjana ; Hogan, Patrick G.
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2021-08, Vol.22 (8), p.983-995
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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Author / Creator:Bunse, Lukas ; Pusch, Stefan ; Bunse, Theresa ; Sahm, Felix ; Sanghvi, Khwab ; Friedrich, Mirco ; Alansary, Dalia ; Sonner, Jana K. ; Green, Edward ; Deumelandt, Katrin ; Kilian, Michael ; Neftel, Cyril ; Uhlig, Stefanie ; Kessler, Tobias ; von Landenberg, Anna ; Berghoff, Anna S. ; Marsh, Kelly ; Steadman, Mya ; Zhu, Dongwei ; Nicolay, Brandon ; Wiestler, Benedikt ; Breckwoldt, Michael O. ; Al-Ali, Ruslan ; Karcher-Bausch, Simone ; Bozza, Matthias ; Oezen, Iris ; Kramer, Magdalena ; Meyer, Jochen ; Habel, Antje ; Eisel, Jessica ; Poschet, Gernot ; Weller, Michael ; Preusser, Matthias ; Nadji-Ohl, Minou ; Thon, Niklas ; Burger, Michael C. ; Harter, Patrick N. ; Ratliff, Miriam ; Harbottle, Richard ; Benner, Axel ; Schrimpf, Daniel ; Okun, Jürgen ; Herold-Mende, Christel ; Turcan, Sevin ; Kaulfuss, Stefan ; Hess‐Stumpp, Holger ; Bieback, Karen ; Cahill, Daniel P. ; Plate, Karl H. ; Hänggi, Daniel ; Dorsch, Marion ; Suvà, Mario L. ; Niemeyer, Barbara A. ; von Deimling, Andreas ; Wick, Wolfgang ; Platten, Michael
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-08, Vol.24 (8), p.1192-1203
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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Author / Creator:Cardoso, Vânia ; Chesné, Julie ; Ribeiro, Hélder Manuel ; García Cassani, Bethania ; Carvalho, Tânia ; Bouchery, Tiffany ; Shah, Kathleen ; BARBOSA MORAIS, NUNO LUÍS ; Harris, Nicola ; Veiga-Fernandes, Henrique
Publisher:London: Springer Nature
Journal title:Nature (London), 2017-09, Vol.549 (7671), p.277-281
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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
Author / Creator:Cox, Thomas R ; Rumney, Robin M H ; Schoof, Erwin M ; Perryman, Lara ; Høye, Anette M ; Agrawal, Ankita ; Bird, Demelza ; Latif, Norain Ab ; Forrest, Hamish ; Evans, Holly R ; Huggins, Iain D ; Lang, Georgina ; Linding, Rune ; Gartland, Alison ; Erler, Janine T
Publisher:England: Nature Publishing Group
Journal title:Nature (London), 2015-06, Vol.522 (7554), p.106-110
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ArticlesPeer ReviewedFull Text
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas
Author / Creator:Quail, Daniela F. ; Bowman, Robert L. ; Akkari, Leila ; Quick, Marsha L. ; Schuhmacher, Alberto J. ; Huse, Jason T. ; Holland, Eric C. ; Sutton, James C. ; Joyce, Johanna A.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-05, Vol.352 (6288), p.952-952
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RANKL as the master regulator of osteoclast differentiation
Author / Creator:Takayanagi, Hiroshi
Publisher:Singapore: Springer Singapore
Journal title:Journal of bone and mineral metabolism, 2021-01, Vol.39 (1), p.13-18
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T-cell exhaustion in the tumor microenvironment
Author / Creator:Jiang, Y ; Li, Y ; Zhu, B
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2015-06, Vol.6 (6), p.e1792-e1792
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ArticlesPeer ReviewedFull Text
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
Author / Creator:Nonomura, Keiko ; Lukacs, Viktor ; Sweet, Daniel T. ; Goddard, Lauren M. ; Kanie, Akemi ; Whitwam, Tess ; Ranade, Sanjeev S. ; Fujimori, Toshihiko ; Kahn, Mark L. ; Patapoutian, Ardem
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-12, Vol.115 (50), p.12817-12822
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ArticlesPeer ReviewedFull Text
The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion
Author / Creator:Jiang, Runqiu ; Tang, Junwei ; Chen, Yun ; Deng, Lei ; Ji, Jie ; Xie, Yu ; Wang, Ke ; Jia, Wei ; Chu, Wen-Ming ; Sun, Beicheng
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15129-15129, Article 15129
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Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
Author / Creator:Blanchard, Joel W. ; Bula, Michael ; Davila-Velderrain, Jose ; Akay, Leyla Anne ; Zhu, Lena ; Frank, Alexander ; Victor, Matheus B. ; Bonner, Julia Maeve ; Mathys, Hansruedi ; Lin, Yuan-Ta ; Ko, Tak ; Bennett, David A. ; Cam, Hugh P. ; Kellis, Manolis ; Tsai, Li-Huei
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-06, Vol.26 (6), p.952-963
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ArticlesPeer ReviewedFull Text
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
Author / Creator:Luo, Jian ; Yang, Zhengfeng ; Ma, Yu ; Yue, Zhiying ; Lin, Hongyu ; Qu, Guojun ; Huang, Jinping ; Dai, Wentao ; Li, Chenghai ; Zheng, Chunbing ; Xu, Leqin ; Chen, Huaqing ; Wang, Jiqiu ; Li, Dali ; Siwko, Stefan ; Penninger, Josef M ; Ning, Guang ; Xiao, Jianru ; Liu, Mingyao
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2016-05, Vol.22 (5), p.539-546
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ArticlesPeer ReviewedFull Text
Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential
Author / Creator:Luchsinger, Larry L. ; de Almeida, Mariana Justino ; Corrigan, David J. ; Mumau, Melanie ; Snoeck, Hans-Willem
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-01, Vol.529 (7587), p.528-531
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ArticlesPeer ReviewedFull Text
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Author / Creator:Wang, Peng ; Alvarez-Perez, Juan-Carlos ; Felsenfeld, Dan P ; Liu, Hongtao ; Sivendran, Sharmila ; Bender, Aaron ; Kumar, Anil ; Sanchez, Roberto ; Scott, Donald K ; Garcia-Ocaña, Adolfo ; Stewart, Andrew F
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-04, Vol.21 (4), p.383-388
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ArticlesPeer ReviewedFull Text
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin
Author / Creator:Zhou, Taifeng ; Gao, Bo ; Fan, Yi ; Liu, Yuchen ; Feng, Shuhao ; Cong, Qian ; Zhang, Xiaolei ; Zhou, Yaxing ; Yadav, Prem S ; Lin, Jiachen ; Wu, Nan ; Zhao, Liang ; Huang, Dongsheng ; Zhou, Shuanhu ; Su, Peiqiang ; Yang, Yingzi
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2020-03, Vol.9
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Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice
Author / Creator:Dankbar, Berno ; Fennen, Michelle ; Brunert, Daniela ; Hayer, Silvia ; Frank, Svetlana ; Wehmeyer, Corinna ; Beckmann, Denise ; Paruzel, Peter ; Bertrand, Jessica ; Redlich, Kurt ; Koers-Wunrau, Christina ; Stratis, Athanasios ; Korb-Pap, Adelheid ; Pap, Thomas
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2015-09, Vol.21 (9), p.1085-1090
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Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling
Author / Creator:Dai, Chunhua ; Hang, Yan ; Shostak, Alena ; Poffenberger, Greg ; Hart, Nathaniel ; Prasad, Nripesh ; Phillips, Neil ; Levy, Shawn E ; Greiner, Dale L ; Shultz, Leonard D ; Bottino, Rita ; Kim, Seung K ; Powers, Alvin C
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-10, Vol.127 (10), p.3835-3844
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The many ways of osteoclast activation
Author / Creator:Lorenzo, Joseph
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-07, Vol.127 (7), p.2530-2532
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MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation
Author / Creator:Luo, Xiaobin ; Pan, Zhenwei ; Shan, Hongli ; Xiao, Jiening ; Sun, Xuelin ; Wang, Ning ; Lin, Huixian ; Xiao, Ling ; Maguy, Ange ; Qi, Xiao-Yan ; Li, Yue ; Gao, Xu ; Dong, Deli ; Zhang, Yong ; Bai, Yunlong ; Ai, Jing ; Sun, Lihua ; Lu, Hang ; Luo, Xiao-Yan ; Wang, Zhiguo ; Lu, Yanjie ; Yang, Baofeng ; Nattel, Stanley
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2013-05, Vol.123 (5), p.1939-1951
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ArticlesPeer ReviewedFull Text
USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses
Author / Creator:Zou, Qiang ; Jin, Jin ; Hu, Hongbo ; Li, Haiyan S ; Romano, Simona ; Xiao, Yichuan ; Nakaya, Mako ; Zhou, Xiaofei ; Cheng, Xuhong ; Yang, Peirong ; Lozano, Guillermina ; Zhu, Chengming ; Watowich, Stephanie S ; Ullrich, Stephen E ; Sun, Shao-Cong
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2014-06, Vol.15 (6), p.562-570
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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells

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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate

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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U

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The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase

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The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

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RANKL as the master regulator of osteoclast differentiation

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T-cell exhaustion in the tumor microenvironment

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Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation

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The long noncoding RNA lnc-EGFR stimulates T-regulatory cells differentiation thus promoting hepatocellular carcinoma immune evasion

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Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption

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Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication

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Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ß-catenin

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Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice

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Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling

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The many ways of osteoclast activation

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MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation

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USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

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