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608 results for Oxidoreductases+-+antagonists+

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ArticlesPeer ReviewedFull Text
Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
Author / Creator:Ikenaga, Naoki ; Peng, Zhen-Wei ; Vaid, Kahini A ; Liu, Susan B ; Yoshida, Shuhei ; Sverdlov, Deanna Y ; Mikels-Vigdal, Amanda ; Smith, Victoria ; Schuppan, Detlef ; Popov, Yury V
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2017-09, Vol.66 (9), p.1697-1708
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Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins
Author / Creator:Lee, Seul-Gi ; Karadeniz, Fatih ; Seo, Youngwan ; Kong, Chang-Suk
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-09, Vol.22 (9), p.1480
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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Author / Creator:Cronin, Shane J. F. ; Seehus, Corey ; Weidinger, Adelheid ; Talbot, Sebastien ; Reissig, Sonja ; Seifert, Markus ; Pierson, Yann ; McNeill, Eileen ; Longhi, Maria Serena ; Turnes, Bruna Lenfers ; Kreslavsky, Taras ; Kogler, Melanie ; Hoffmann, David ; Ticevic, Melita ; da Luz Scheffer, Débora ; Tortola, Luigi ; Cikes, Domagoj ; Jais, Alexander ; Rangachari, Manu ; Rao, Shuan ; Paolino, Magdalena ; Novatchkova, Maria ; Aichinger, Martin ; Barrett, Lee ; Latremoliere, Alban ; Wirnsberger, Gerald ; Lametschwandtner, Guenther ; Busslinger, Meinrad ; Zicha, Stephen ; Latini, Alexandra ; Robson, Simon C. ; Waisman, Ari ; Andrews, Nick ; Costigan, Michael ; Channon, Keith M. ; Weiss, Guenter ; Kozlov, Andrey V. ; Tebbe, Mark ; Johnsson, Kai ; Woolf, Clifford J. ; Penninger, Josef M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-11, Vol.563 (7732), p.564-568
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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets
Author / Creator:Drummond, Grant R. ; Selemidis, Stavros ; Griendling, Kathy K. ; Sobey, Christopher G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2011-06, Vol.10 (6), p.453-471
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Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases
Author / Creator:Battista, Theo ; Colotti, Gianni ; Ilari, Andrea ; Fiorillo, Annarita
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-04, Vol.25 (8), p.1924
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Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis
Author / Creator:Li, Rongkun ; Wang, Yahui ; Zhang, Xiaoxin ; Feng, Mingxuan ; Ma, Jun ; Li, Jun ; Yang, Xiaomei ; Fang, Fang ; Xia, Qiang ; Zhang, Zhigang ; Shang, Mingyi ; Jiang, Shuheng
Publisher:England: BioMed Central Ltd
Journal title:Molecular cancer, 2019-01, Vol.18 (1), p.18-18, Article 18
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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2
Author / Creator:Xiong, Rui ; Zhang, Leike ; Li, Shiliang ; Sun, Yuan ; Ding, Minyi ; Wang, Yong ; Zhao, Yongliang ; Wu, Yan ; Shang, Weijuan ; Jiang, Xiaming ; Shan, Jiwei ; Shen, Zihao ; Tong, Yi ; Xu, Liuxin ; Chen, Yu ; Liu, Yingle ; Zou, Gang ; Lavillete, Dimitri ; Zhao, Zhenjiang ; Wang, Rui ; Zhu, Lili ; Xiao, Gengfu ; Lan, Ke ; Li, Honglin ; Xu, Ke
Publisher:Beijing: Higher Education Press
Journal title:Protein & cell, 2020-10, Vol.11 (10), p.723-739
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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease
Author / Creator:Gray, Stephen P. ; Jha, Jay C. ; Kennedy, Kit ; van Bommel, Erik ; Chew, Phyllis ; Szyndralewiez, Cedric ; Touyz, Rhian M. ; Schmidt, Harald H. H. W. ; Cooper, Mark E. ; Jandeleit-Dahm, Karin A. M.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2017-05, Vol.60 (5), p.927-937
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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
Author / Creator:Turner, Nigel ; Lim, Xin Ying ; Toop, Hamish D. ; Osborne, Brenna ; Brandon, Amanda E. ; Taylor, Elysha N. ; Fiveash, Corrine E. ; Govindaraju, Hemna ; Teo, Jonathan D. ; McEwen, Holly P. ; Couttas, Timothy A. ; Butler, Stephen M. ; Das, Abhirup ; Kowalski, Greg M. ; Bruce, Clinton R. ; Hoehn, Kyle L. ; Fath, Thomas ; Schmitz-Peiffer, Carsten ; Cooney, Gregory J. ; Montgomery, Magdalene K. ; Morris, Jonathan C. ; Don, Anthony S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-08, Vol.9 (1), p.3165-14, Article 3165
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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
Author / Creator:Barry-Hamilton, Vivian ; Spangler, Rhyannon ; Marshall, Derek ; McCauley, Scott ; Rodriguez, Hector M ; Oyasu, Miho ; Mikels, Amanda ; Vaysberg, Maria ; Ghermazien, Haben ; Wai, Carol ; Garcia, Carlos A ; Velayo, Arleene C ; Jorgensen, Brett ; Biermann, Donna ; Tsai, Daniel ; Green, Jennifer ; Zaffryar-Eilot, Shelly ; Holzer, Alison ; Ogg, Scott ; Thai, Dung ; Neufeld, Gera ; Van Vlasselaer, Peter ; Smith, Victoria
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2010-09, Vol.16 (9), p.1009-1017
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Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
Author / Creator:Vos, Melissa ; Dulovic-Mahlow, Marija ; Mandik, Frida ; Frese, Lisa ; Kanana, Yuliia ; Diaw, Sokhna Haissatou ; Depperschmidt, Julia ; Böhm, Claudia ; Rohr, Jonas ; Lohnau, Thora ; König, Inke R. ; Klein, Christine
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-10, Vol.118 (43), p.1-10
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Efficient knockout of phytoene desaturase gene using CRISPR/Cas9 in melon
Author / Creator:Hooghvorst, Isidre ; López-Cristoffanini, Camilo ; Nogués, Salvador
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-11, Vol.9 (1), p.17077-7, Article 17077
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CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I
Author / Creator:Zabaleta, Nerea ; Barberia, Miren ; Martin-Higueras, Cristina ; Zapata-Linares, Natalia ; Betancor, Isabel ; Rodriguez, Saray ; Martinez-Turrillas, Rebeca ; Torella, Laura ; Vales, Africa ; Olagüe, Cristina ; Vilas-Zornoza, Amaia ; Castro-Labrador, Laura ; Lara-Astiaso, David ; Prosper, Felipe ; Salido, Eduardo ; Gonzalez-Aseguinolaza, Gloria ; Rodriguez-Madoz, Juan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-12, Vol.9 (1), p.5454-9, Article 5454
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DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Author / Creator:Abrahams, Katherine A. ; Batt, Sarah M. ; Gurcha, Sudagar S. ; Veerapen, Natacha ; Bashiri, Ghader ; Besra, Gurdyal S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-06, Vol.14 (1), p.3828-3828, Article 3828
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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation
Author / Creator:Lan, Tian ; Kisseleva, Tatiana ; Brenner, David A.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-07, Vol.10 (7), p.e0129743
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Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence
Author / Creator:Chen, Feifei ; Di, Hongxia ; Wang, Youxin ; Cao, Qiao ; Xu, Bin ; Zhang, Xue ; Yang, Nana ; Liu, Guijie ; Yang, Cai-Guang ; Xu, Yong ; Jiang, Hualiang ; Lian, Fulin ; Zhang, Naixia ; Li, Jian ; Lan, Lefu
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2016-03, Vol.12 (3), p.174-179
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The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis
Author / Creator:Schilter, Heidi ; Findlay, Alison D. ; Perryman, Lara ; Yow, Tin T. ; Moses, Joshua ; Zahoor, Amna ; Turner, Craig I. ; Deodhar, Mandar ; Foot, Jonathan S. ; Zhou, Wenbin ; Greco, Angelique ; Joshi, Amar ; Rayner, Benjamin ; Townsend, Sarah ; Buson, Alberto ; Jarolimek, Wolfgang
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2019-03, Vol.23 (3), p.1759-1770
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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Author / Creator:Wang, Feng ; Sambandan, Dhinakaran ; Halder, Rajkumar ; Wang, Jianing ; Batt, Sarah M. ; Weinrick, Brian ; Ahmad, Insha ; Yang, Pengyu ; Zhang, Yong ; Kim, John ; Hassani, Morad ; Huszar, Stanislav ; Trefzer, Claudia ; Ma, Zhenkun ; Kaneko, Takushi ; Mdluli, Khisi E. ; Franzblau, Scott ; Chatterjee, Arnab K. ; Johnsson, Kai ; Mikusova, Katarina ; Besra, Gurdyal S. ; Fütterer, Klaus ; Robbins, Scott H. ; Barnes, S. Whitney ; Walker, John R. ; Jacobs, William R. ; Schultz, Peter G.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (27), p.E2510-E2517
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Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia
Author / Creator:Pankowicz, Francis P. ; Barzi, Mercedes ; Legras, Xavier ; Hubert, Leroy ; Mi, Tian ; Tomolonis, Julie A. ; Ravishankar, Milan ; Sun, Qin ; Yang, Diane ; Borowiak, Malgorzata ; Sumazin, Pavel ; Elsea, Sarah H. ; Bissig-Choisat, Beatrice ; Bissig, Karl-Dimiter
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-08, Vol.7 (1), p.12642-12642, Article 12642
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Unveiling potent inhibitors for schistosomiasis through ligand-based drug design, molecular docking, molecular dynamics simulations and pharmacokinetics predictions
Author / Creator:Ja’afaru, Saudatu Chinade ; Uzairu, Adamu ; Bayil, Imren ; Sallau, Muhammed Sani ; Ndukwe, George Iloegbulam ; Ibrahim, Muhammad Tukur ; Moin, Abu Tayab ; Mollah, A. K. M. Moniruzzaman ; Absar, Nurul
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-06, Vol.19 (6), p.e0302390
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Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal

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Anti-Melanogenic Effects of Flavonoid Glycosides from Limonium tetragonum (Thunb.) Bullock via Inhibition of Tyrosinase and Tyrosinase-Related Proteins

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The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

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Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

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Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases

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Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis

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Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

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Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

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A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism

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Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

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Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency

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Efficient knockout of phytoene desaturase gene using CRISPR/Cas9 in melon

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CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I

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DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid

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Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation

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Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

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The lysyl oxidase like 2/3 enzymatic inhibitor, PXS‐5153A, reduces crosslinks and ameliorates fibrosis

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Identification of a small molecule with activity against drug-resistant and persistent tuberculosis

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Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia

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Unveiling potent inhibitors for schistosomiasis through ligand-based drug design, molecular docking, molecular dynamics simulations and pharmacokinetics predictions

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