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41 results for Somatic+Hypermutation,+Immunoglobulin+-+immunology

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ArticlesPeer ReviewedFull Text
Defining HPV-specific B cell responses in patients with head and neck cancer
Author / Creator:Wieland, Andreas ; Patel, Mihir R. ; Cardenas, Maria A. ; Eberhardt, Christiane S. ; Hudson, William H. ; Obeng, Rebecca C. ; Griffith, Christopher C. ; Wang, Xu ; Chen, Zhuo G. ; Kissick, Haydn T. ; Saba, Nabil F. ; Ahmed, Rafi
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-09, Vol.597 (7875), p.274-278
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Long-primed germinal centres with enduring affinity maturation and clonal migration
Author / Creator:Lee, Jeong Hyun ; Sutton, Henry J. ; Cottrell, Christopher A. ; Phung, Ivy ; Ozorowski, Gabriel ; Sewall, Leigh M. ; Nedellec, Rebecca ; Nakao, Catherine ; Silva, Murillo ; Richey, Sara T. ; Torres, Jonathan L. ; Lee, Wen-Hsin ; Georgeson, Erik ; Kubitz, Michael ; Hodges, Sam ; Mullen, Tina-Marie ; Adachi, Yumiko ; Cirelli, Kimberly M. ; Kaur, Amitinder ; Allers, Carolina ; Fahlberg, Marissa ; Grasperge, Brooke F. ; Dufour, Jason P. ; Schiro, Faith ; Aye, Pyone P. ; Kalyuzhniy, Oleksandr ; Liguori, Alessia ; Carnathan, Diane G. ; Silvestri, Guido ; Shen, Xiaoying ; Montefiori, David C. ; Veazey, Ronald S. ; Ward, Andrew B. ; Hangartner, Lars ; Burton, Dennis R. ; Irvine, Darrell J. ; Schief, William R. ; Crotty, Shane
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-09, Vol.609 (7929), p.998-1004
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B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen
Author / Creator:Puga, Irene ; Cols, Montserrat ; Barra, Carolina M ; He, Bing ; Cassis, Linda ; Gentile, Maurizio ; Comerma, Laura ; Chorny, Alejo ; Shan, Meimei ; Xu, Weifeng ; Magri, Giuliana ; Knowles, Daniel M ; Tam, Wayne ; Chiu, April ; Bussel, James B ; Serrano, Sergi ; Lorente, José Antonio ; Bellosillo, Beatriz ; Lloreta, Josep ; Juanpere, Nuria ; Alameda, Francesc ; Baró, Teresa ; de Heredia, Cristina Díaz ; Torán, Núria ; Català, Albert ; Torrebadell, Montserrat ; Fortuny, Claudia ; Cusí, Victoria ; Carreras, Carmen ; Diaz, George A ; Blander, J Magarian ; Farber, Claire-Michèle ; Silvestri, Guido ; Cunningham-Rundles, Charlotte ; Calvillo, Michaela ; Dufour, Carlo ; Notarangelo, Lucia Dora ; Lougaris, Vassilios ; Plebani, Alessandro ; Casanova, Jean-Laurent ; Ganal, Stephanie C ; Diefenbach, Andreas ; Aróstegui, Juan Ignacio ; Juan, Manel ; Yagüe, Jordi ; Mahlaoui, Nizar ; Donadieu, Jean ; Chen, Kang ; Cerutti, Andrea
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2012-02, Vol.13 (2), p.170-180
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Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity
Author / Creator:Casellas, Rafael ; Basu, Uttiya ; Yewdell, William T. ; Chaudhuri, Jayanta ; Robbiani, Davide F. ; Di Noia, Javier M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2016-03, Vol.16 (3), p.164-176
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Landscape of B cell immunity and related immune evasion in human cancers
Author / Creator:Hu, Xihao ; Zhang, Jian ; Wang, Jin ; Fu, Jingxin ; Li, Taiwen ; Zheng, Xiaoqi ; Wang, Binbin ; Gu, Shengqing ; Jiang, Peng ; Fan, Jingyu ; Ying, Xiaomin ; Zhang, Jing ; Carroll, Michael C. ; Wucherpfennig, Kai W. ; Hacohen, Nir ; Zhang, Fan ; Zhang, Peng ; Liu, Jun S. ; Li, Bo ; Liu, X. Shirley
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2019-03, Vol.51 (3), p.560-567
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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity
Author / Creator:Sabouri, Zahra ; Schofield, Peter ; Horikawa, Keisuke ; Spierings, Emily ; Kipling, David ; Randall, Katrina L ; Langley, David ; Roome, Brendan ; Vazquez-Lombardi, Rodrigo ; Rouet, Romain ; Hermes, Jana ; Chan, Tyani D ; Brink, Robert ; Dunn-Walters, Deborah K ; Christ, Daniel ; Goodnow, Christopher C
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (25), p.E2567-E2575
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Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody
Author / Creator:Ying, Tianlei ; Prabakaran, Ponraj ; Du, Lanying ; Shi, Wei ; Feng, Yang ; Wang, Yanping ; Wang, Lingshu ; Li, Wei ; Jiang, Shibo ; Dimitrov, Dimiter S. ; Zhou, Tongqing
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-09, Vol.6 (1), p.8223-8223, Article 8223
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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense
Author / Creator:Wei, Min ; Shinkura, Reiko ; Doi, Yasuko ; Maruya, Mikako ; Fagarasan, Sidonia ; Honjo, Tasuku
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2011-03, Vol.12 (3), p.264-270
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A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells
Author / Creator:Fritz, Eric L ; Rosenberg, Brad R ; Lay, Kenneth ; Mihailović, Aleksandra ; Tuschl, Thomas ; Papavasiliou, F Nina
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2013-07, Vol.14 (7), p.749-755
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Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint
Author / Creator:Cantaert, Tineke ; Schickel, Jean-Nicolas ; Bannock, Jason M ; Ng, Yen-Shing ; Massad, Christopher ; Delmotte, Fabien R ; Yamakawa, Natsuko ; Glauzy, Salome ; Chamberlain, Nicolas ; Kinnunen, Tuure ; Menard, Laurence ; Lavoie, Aubert ; Walter, Jolan E ; Notarangelo, Luigi D ; Bruneau, Julie ; Al-Herz, Waleed ; Kilic, Sara Sebnem ; Ochs, Hans D ; Cunningham-Rundles, Charlotte ; van der Burg, Mirjam ; Kuijpers, Taco W ; Kracker, Sven ; Kaneko, Hideo ; Sekinaka, Yujin ; Nonoyama, Shigeaki ; Durandy, Anne ; Meffre, Eric
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-11, Vol.126 (11), p.4289-4302
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Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
Author / Creator:Imai, Kohsuke ; Slupphaug, Geir ; Lee, Wen-I ; Revy, Patrick ; Nonoyama, Shigeaki ; Catalan, Nadia ; Yel, Leman ; Forveille, Monique ; Kavli, Bodil ; Krokan, Hans E ; Ochs, Hans D ; Fischer, Alain ; Durandy, Anne
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2003-10, Vol.4 (10), p.1023-1028
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Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution
Author / Creator:Senavirathne, Gayan ; Bertram, Jeffrey G. ; Jaszczur, Malgorzata ; Chaurasiya, Kathy R. ; Pham, Phuong ; Mak, Chi H. ; Goodman, Myron F. ; Rueda, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-12, Vol.6 (1), p.10209, Article 10209
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HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
Author / Creator:Park, Seok-Rae ; Zan, Hong ; Pal, Zsuzsanna ; Zhang, Jinsong ; Al-Qahtani, Ahmed ; Pone, Egest J ; Xu, Zhenming ; Mai, Thach ; Casali, Paolo
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2009-05, Vol.10 (5), p.540-550
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Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection
Author / Creator:Halemano, Kalani ; Guo, Kejun ; Heilman, Karl J. ; Barrett, Bradley S. ; Smith, Diana S. ; Hasenkrug, Kim J. ; Santiago, Mario L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-05, Vol.111 (21), p.7759-7764
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B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
Author / Creator:Tran, Thinh Huy ; Nakata, Mikiyo ; Suzuki, Keiichiro ; Begum, Nasim A ; Shinkura, Reiko ; Fagarasan, Sidonia ; Honjo, Tasuku ; Nagaoka, Hitoshi
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2010-02, Vol.11 (2), p.148-154
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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
Author / Creator:Roa, Sergio ; Avdievich, Elena ; Peled, Jonathan U ; MacCarthy, Thomas ; Werling, Uwe ; Kuang, Fei Li ; Kan, Rui ; Zhao, Chunfang ; Bergman, Aviv ; Cohen, Paula E ; Edelmann, Winfried ; Scharff, Matthew D
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-10, Vol.105 (42), p.16248-16253
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AID mutant analyses indicate requirement for class-switch-specific cofactors
Author / Creator:Ta, Van-Thanh ; Nagaoka, Hitoshi ; Catalan, Nadia ; Durandy, Anne ; Fischer, Alain ; Imai, Kohsuke ; Nonoyama, Shigeaki ; Tashiro, Junko ; Ikegawa, Masaya ; Ito, Satomi ; Kinoshita, Kazuo ; Muramatsu, Masamichi ; Honjo, Tasuku
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2003-09, Vol.4 (9), p.843-848
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The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes
Author / Creator:Bahjat, Mahnoush ; Guikema, Jeroen E J
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2017-08, Vol.18 (9), p.1876
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Separate domains of AID are required for somatic hypermutation and class-switch recombination
Author / Creator:Shinkura, Reiko ; Ito, Satomi ; Begum, Nasim A ; Nagaoka, Hitoshi ; Muramatsu, Masamichi ; Kinoshita, Kazuo ; Sakakibara, Yoshimasa ; Hijikata, Hiroko ; Honjo, Tasuku
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2004-07, Vol.5 (7), p.707-712
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ArticlesPeer ReviewedFull Text
Development of a Bioinformatics Framework for the Detection of Gene Conversion and the Analysis of Combinatorial Diversity in Immunoglobulin Heavy Chains in Four Cattle Breeds
Author / Creator:Walther, Stefanie ; Tietze, Manfred ; Czerny, Claus-Peter ; König, Sven ; Diesterbeck, Ulrike S
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-11, Vol.11 (11), p.e0164567-e0164567
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Defining HPV-specific B cell responses in patients with head and neck cancer

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Long-primed germinal centres with enduring affinity maturation and clonal migration

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B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

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Mutations, kataegis and translocations in B cells: understanding AID promiscuous activity

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Landscape of B cell immunity and related immune evasion in human cancers

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Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity

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Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

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Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense

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A comprehensive analysis of the effects of the deaminase AID on the transcriptome and methylome of activated B cells

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Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint

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Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

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Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution

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HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation

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Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection

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B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers

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Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression

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AID mutant analyses indicate requirement for class-switch-specific cofactors

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The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes

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Separate domains of AID are required for somatic hypermutation and class-switch recombination

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Development of a Bioinformatics Framework for the Detection of Gene Conversion and the Analysis of Combinatorial Diversity in Immunoglobulin Heavy Chains in Four Cattle Breeds

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