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Select record 21
ArticlesPeer ReviewedFull Text
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I
Author / Creator:Peisley, Alys ; Wu, Bin ; Xu, Hui ; Chen, Zhijian J. ; Hur, Sun
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-05, Vol.509 (7498), p.110-114
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ArticlesPeer ReviewedFull Text
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Author / Creator:Liu, Siqi ; Cai, Xin ; Wu, Jiaxi ; Cong, Qian ; Chen, Xiang ; Li, Tuo ; Du, Fenghe ; Ren, Junyao ; Wu, You-Tong ; Grishin, Nick V. ; Chen, Zhijian J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-03, Vol.347 (6227), p.1217-1217
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ArticlesPeer ReviewedFull Text
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Author / Creator:Gao, Daxing ; Li, Tuo ; Li, Xiao-Dong ; Chen, Xiang ; Li, Quan-Zhen ; Wight-Carter, Mary ; Chen, Zhijian J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (42), p.E5699-E5705
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ArticlesPeer ReviewedFull Text
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Author / Creator:Gao, Daxing ; Wu, Jiaxi ; Wu, You-Tong ; Du, Fenghe ; Aroh, Chukwuemika ; Yan, Nan ; Sun, Lijun ; Chen, Zhijian J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-08, Vol.341 (6148), p.903-906
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ArticlesPeer ReviewedFull Text
IKKβ is an IRF5 kinase that instigates inflammation
Author / Creator:Ren, Junyao ; Chen, Xiang ; Chen, Zhijian J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (49), p.17438-17443
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Select record 26
ArticlesPeer ReviewedFull Text
cGAS restricts colon cancer development by protecting intestinal barrier integrity
Author / Creator:Hu, Shuiqing ; Fang, Yan ; Chen, Xiang ; Cheng, Tianlei ; Zhao, Miaoqing ; Du, Mingjian ; Li, Tuo ; Li, Minghao ; Zeng, Zhiqun ; Wei, Yonglong ; Gu, Zhimin ; Zhang, Conggang ; Sun, Lijun ; Chen, Zhijian J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (23), p.1-12
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Select record 27
ArticlesPeer ReviewedFull Text
An Argonaute phosphorylation cycle promotes microRNA-mediated silencing
Author / Creator:Golden, Ryan J. ; Chen, Beibei ; Li, Tuo ; Braun, Juliane ; Manjunath, Hema ; Chen, Xiang ; Wu, Jiaxi ; Schmid, Vanessa ; Chang, Tsung-Cheng ; Kopp, Florian ; Ramirez-Martinez, Andres ; Tagliabracci, Vincent S. ; Chen, Zhijian J. ; Xie, Yang ; Mendell, Joshua T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-02, Vol.542 (7640), p.197-202
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ArticlesPeer ReviewedFull Text
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
Author / Creator:Uslu, Ugur ; Sun, Lijun ; Castelli, Sofia ; Finck, Amanda V. ; Assenmacher, Charles-Antoine ; Young, Regina M. ; Chen, Zhijian J. ; June, Carl H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.3933-16, Article 3933
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ArticlesPeer ReviewedFull Text
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
Author / Creator:Shi, Heping ; Jiaxi Wu ; Zhijian J. Chen ; Chuo Chen
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (29), p.8947-8952
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Select record 30
ArticlesPeer ReviewedFull Text
Direct activation of protein kinases by unanchored polyubiquitin chains
Author / Creator:Xia, Zong-Ping ; Sun, Lijun ; Chen, Xiang ; Pineda, Gabriel ; Jiang, Xiaomo ; Adhikari, Anirban ; Zeng, Wenwen ; Chen, Zhijian J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-09, Vol.461 (7260), p.114-119
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Select record 31
ArticlesPeer ReviewedFull Text
MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades
Author / Creator:Liu, Siqi ; Chen, Jueqi ; Cai, Xin ; Wu, Jiaxi ; Chen, Xiang ; Wu, You-Tong ; Sun, Lijun ; Chen, Zhijian J
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2013-08, Vol.2, p.e00785-e00785
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Select record 32
ArticlesPeer ReviewedFull Text
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Author / Creator:Chen, Jueqi ; Chen, Zhijian J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-12, Vol.564 (7734), p.71-76
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Select record 33
ArticlesPeer ReviewedFull Text
Sequence specific detection of bacterial 23S ribosomal RNA by TLR13
Author / Creator:Li, Xiao-Dong ; Chen, Zhijian James
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2012-10, Vol.1, p.e00102-e00102
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Select record 34
ArticlesPeer ReviewedFull Text
Hepatitis C Virus Protease NS3/4A Cleaves Mitochondrial Antiviral Signaling Protein off the Mitochondria to Evade Innate Immunity
Author / Creator:Li, Xiao-Dong ; Sun, Lijun ; Rashu B. Seth ; Gabriel Pineda ; Chen, Zhijian J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2005-12, Vol.102 (49), p.17717-17722
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Select record 35
ArticlesPeer ReviewedFull Text
Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
Author / Creator:Kuss-Duerkop, Sharon K. ; Wang, Juan ; Mena, Ignacio ; White, Kris ; Metreveli, Giorgi ; Sakthivel, Ramanavelan ; Mata, Miguel A. ; Muñoz-Moreno, Raquel ; Chen, Xiang ; Krammer, Florian ; Diamond, Michael S. ; Chen, Zhijian J. ; García-Sastre, Adolfo ; Fontoura, Beatriz M. A.
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2017-09, Vol.13 (9), p.e1006635
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Select record 36
ArticlesPeer ReviewedFull Text
Structural basis for the prion-like MAVS filaments in antiviral innate immunity
Author / Creator:Xu, Hui ; He, Xiaojing ; Zheng, Hui ; Huang, Lily J ; Hou, Fajian ; Yu, Zhiheng ; de la Cruz, Michael Jason ; Borkowski, Brian ; Zhang, Xuewu ; Chen, Zhijian J ; Jiang, Qiu-Xing
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2014-02, Vol.3, p.e01489-e01489
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Select record 37
ArticlesPeer ReviewedFull Text
Mathematical model of mechanobiology of acute and repeated synaptic injury and systemic biomarker kinetics
Author / Creator:Gharahi, Hamidreza ; Garimella, Harsha T. ; Chen, Zhijian J. ; Gupta, Raj K. ; Przekwas, Andrzej
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in cellular neuroscience, 2023-02, Vol.17, p.1007062-1007062
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Select record 38
ArticlesPeer ReviewedFull Text
MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins
Author / Creator:Lei, Yu ; Moore, Chris B. ; Liesman, Rachael M. ; O'Connor, Brian P. ; Bergstralh, Daniel T. ; Chen, Zhijian J. ; Pickles, Raymond J. ; Ting, Jenny P.-Y.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2009-03, Vol.4 (5), p.e5466-e5466
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Select record 39
ArticlesPeer ReviewedFull Text
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
Author / Creator:Yum, Seoyun ; Li, Minghao ; Fang, Yan ; Chen, Zhijian J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (14), p.1-9
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Select record 40
ArticlesPeer ReviewedFull Text
Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2
Author / Creator:Fieber, Christina ; Janos, Marton ; Koestler, Tina ; Gratz, Nina ; Li, Xiao-Dong ; Castiglia, Virginia ; Aberle, Marion ; Sauert, Martina ; Wegner, Mareike ; Alexopoulou, Lena ; Kirschning, Carsten J. ; Chen, Zhijian J. ; von Haeseler, Arndt ; Kovarik, Pavel
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-03, Vol.10 (3), p.e0119727-e0119727
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Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

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Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

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IKKβ is an IRF5 kinase that instigates inflammation

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cGAS restricts colon cancer development by protecting intestinal barrier integrity

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An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

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The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion

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Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING

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Direct activation of protein kinases by unanchored polyubiquitin chains

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MAVS recruits multiple ubiquitin E3 ligases to activate antiviral signaling cascades

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PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation

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Sequence specific detection of bacterial 23S ribosomal RNA by TLR13

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Hepatitis C Virus Protease NS3/4A Cleaves Mitochondrial Antiviral Signaling Protein off the Mitochondria to Evade Innate Immunity

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Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication

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Structural basis for the prion-like MAVS filaments in antiviral innate immunity

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Mathematical model of mechanobiology of acute and repeated synaptic injury and systemic biomarker kinetics

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MAVS-Mediated Apoptosis and Its Inhibition by Viral Proteins

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TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

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Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2

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