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A Facile Synthesis of 5'-Fluoro-5'-deoxyacadesine (5'-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
Author / Creator:D'Errico, Stefano ; Oliviero, Giorgia ; Borbone, Nicola ; Amato, Jussara ; D'Alonzo, Daniele ; Piccialli, Vincenzo ; Mayol, Luciano ; Piccialli, Gennaro
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2012-11, Vol.17 (11), p.13036-13044
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AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis
Author / Creator:Guo, Deliang ; Hildebrandt, Isabel J ; Prins, Robert M ; Soto, Horacio ; Mazzotta, Mary M ; Dang, Julie ; Czernin, Johannes ; Shyy, John Y.-J ; Watson, Andrew D ; Phelps, Michael ; Radu, Caius G ; Cloughesy, Timothy F ; Mischel, Paul S
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-08, Vol.106 (31), p.12932-12937
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Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies
Author / Creator:Hashempour, Shokoufeh ; Shahabadi, Nahid ; Adewoye, Aishat ; Murphy, Brennen ; Rouse, Camaray ; Salvatore, Brian A. ; Stratton, Christopher ; Mahdavian, Elahe
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-11, Vol.25 (22), p.5410
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The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting
Author / Creator:Hall, Derek T ; Griss, Takla ; Ma, Jennifer F ; Sanchez, Brenda Janice ; Sadek, Jason ; Tremblay, Anne Marie K ; Mubaid, Souad ; Omer, Amr ; Ford, Rebecca J ; Bedard, Nathalie ; Pause, Arnim ; Wing, Simon S ; Di Marco, Sergio ; Steinberg, Gregory R ; Jones, Russell G ; Gallouzi, Imed‐Eddine
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2018-07, Vol.10 (7), p.1-n/a
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Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy
Author / Creator:Chandrasekaran, Krish ; Choi, Joungil ; Salimian, Mohammad ; Hedayat, Ahmad F. ; Russell, James W.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-01, Vol.26 (1), p.80
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AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model
Author / Creator:Hu, Liangshuo ; Su, Lin ; Dong, Zhixia ; Wu, Yunhua ; Lv, Yi ; George, Jacob ; Wang, Jianhua
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Journal of molecular medicine (Berlin, Germany), 2019-03, Vol.97 (3), p.423-434
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AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation
Author / Creator:Lanner, Johanna T ; Georgiou, Dimitra K ; Dagnino-Acosta, Adan ; Ainbinder, Alina ; Cheng, Qing ; Joshi, Aditya D ; Chen, Zanwen ; Yarotskyy, Viktor ; Oakes, Joshua M ; Lee, Chang Seok ; Monroe, Tanner O ; Santillan, Arturo ; Dong, Keke ; Goodyear, Laurie ; Ismailov, Iskander I ; Rodney, George G ; Dirksen, Robert T ; Hamilton, Susan L
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-02, Vol.18 (2), p.244-251
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AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
Author / Creator:Višnjić, Dora ; Lalić, Hrvoje ; Dembitz, Vilma ; Tomić, Barbara ; Smoljo, Tomislav
Publisher:Basel: MDPI AG
Journal title:Cells (Basel, Switzerland), 2021-05, Vol.10 (5), p.1095
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AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair
Author / Creator:Wu, Yunhua ; Duan, Xianglong ; Gao, Zengzhan ; Yang, Ni ; Xue, Fei
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2022-09, Vol.17 (9), p.e0272928-e0272928
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5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
Author / Creator:Martin, Lisa Maria ; Möller, Moritz ; Weiss, Ulrike ; Russe, Otto Quintus ; Scholich, Klaus ; Pierre, Sandra ; Geisslinger, Gerd ; Niederberger, Ellen
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-07, Vol.20 (13), p.3255
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AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway
Author / Creator:Su, Chia-Cheng ; Hsieh, Kun-Lin ; Liu, Po-Len ; Yeh, Hsin-Chih ; Huang, Shu-Pin ; Fang, Shih-Hua ; Cheng, Wei-Chung ; Huang, Kuan-Hua ; Chiu, Fang-Yen ; Lin, I-Ling ; Huang, Ming-Yii ; Li, Chia-Yang
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-04, Vol.20 (7), p.1647
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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1
Author / Creator:Aftab, Fareesa ; Rodriguez-Fuguet, Alice ; Silva, Luis ; Kobayashi, Ikei S. ; Sun, Jiao ; Politi, Katerina ; Levantini, Elena ; Zhang, Wei ; Kobayashi, Susumu S. ; Zhang, Wen Cai
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2023-05, Vol.128 (9), p.1647-1664
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AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy
Author / Creator:Wan, Teng ; Chen, Zhuan ; Li, Jie ; Yuan, Xiangyi ; Zheng, Mingmeng ; Qin, Li ; Zhang, Lu ; Hou, Tong ; Liu, Cuiqing ; Li, Ran
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.8689-11, Article 8689
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Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1
Author / Creator:Fodor, Tamás ; Szántó, Magdolna ; Abdul-Rahman, Omar ; Nagy, Lilla ; Dér, Ádám ; Kiss, Borbála ; Bai, Peter
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-02, Vol.11 (2), p.e0150232-e0150232
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AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages
Author / Creator:Kirchner, Johannes ; Brüne, Bernhard ; Namgaladze, Dmitry
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-05, Vol.8 (1), p.7801-9, Article 7801
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AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess
Author / Creator:Samsonov, Mikhail V. ; Podkuychenko, Nikita V. ; Khapchaev, Asker Y. ; Efremov, Eugene E. ; Yanushevskaya, Elena V. ; Vlasik, Tatiana N. ; Lankin, Vadim Z. ; Stafeev, Iurii S. ; Skulachev, Maxim V. ; Shestakova, Marina V. ; Vorotnikov, Alexander V. ; Shirinsky, Vladimir P.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-12, Vol.23 (1), p.211
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The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts
Author / Creator:Chen, Kuan-Hsing ; Hsu, Hsiang-Hao ; Lee, Cheng-Chia ; Yen, Tzu-Hai ; Ko, Yi-Ching ; Yang, Chih-Wei ; Hung, Cheng-Chieh
Publisher:United States: Public Library of Science
Journal title:PloS one, 2014-09, Vol.9 (9), p.e106554-e106554
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AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver
Author / Creator:Liu, Shudong ; Jing, Fei ; Yu, Chunxiao ; Gao, Ling ; Qin, Yejun ; Zhao, Jiajun
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-05, Vol.10 (5), p.e0124951-e0124951
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AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin
Author / Creator:Börgeson, Emma ; Wallenius, Ville ; Syed, Gulam H. ; Darshi, Manjula ; Lantero Rodriguez, Juan ; Biörserud, Christina ; Ragnmark Ek, Malin ; Björklund, Per ; Quiding-Järbrink, Marianne ; Fändriks, Lars ; Godson, Catherine ; Sharma, Kumar
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2017-04, Vol.60 (4), p.729-739
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Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle
Author / Creator:Kramer, Henning F. ; Witczak, Carol A. ; Fujii, Nobuharu ; Jessen, Niels ; Taylor, Eric B. ; Arnolds, David E. ; Sakamoto, Kei ; Hirshman, Michael F. ; Goodyear, Laurie J.
Publisher:United States: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2006-07, Vol.55 (7), p.2067-2076
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A Facile Synthesis of 5'-Fluoro-5'-deoxyacadesine (5'-F-AICAR): A Novel Non-phosphorylable AICAR Analogue

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AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

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Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies

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The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

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Administration of AICAR, an AMPK Activator, Prevents and Reverses Diabetic Polyneuropathy (DPN) by Regulating Mitophagy

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AMPK agonist AICAR ameliorates portal hypertension and liver cirrhosis via NO pathway in the BDL rat model

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AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

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AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review

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AICAR attenuates postoperative abdominal adhesion formation by inhibiting oxidative stress and promoting mesothelial cell repair

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5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift

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AICAR Induces Apoptosis and Inhibits Migration and Invasion in Prostate Cancer Cells Through an AMPK/mTOR-Dependent Pathway

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An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1

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AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy

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Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

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AICAR inhibits NFκB DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages

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AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess

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The AMPK Agonist AICAR Inhibits TGF-β1 Induced Activation of Kidney Myofibroblasts

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AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver

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AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin

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Distinct Signals Regulate AS160 Phosphorylation in Response to Insulin, AICAR, and Contraction in Mouse Skeletal Muscle

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