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ArticlesPeer ReviewedFull Text
Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination
Author / Creator:Qiao, Huanyu ; Prasada Rao, H B D ; Yang, Ye ; Fong, Jared H ; Cloutier, Jeffrey M ; Deacon, Dekker C ; Nagel, Kathryn E ; Swartz, Rebecca K ; Strong, Edward ; Holloway, J Kim ; Cohen, Paula E ; Schimenti, John ; Ward, Jeremy ; Hunter, Neil
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2014-02, Vol.46 (2), p.194-199
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RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6
Author / Creator:Szenker-Ravi, Emmanuelle ; Altunoglu, Umut ; Leushacke, Marc ; Bosso-Lefèvre, Célia ; Khatoo, Muznah ; Thi Tran, Hong ; Naert, Thomas ; Noelanders, Rivka ; Hajamohideen, Amin ; Beneteau, Claire ; de Sousa, Sergio B. ; Karaman, Birsen ; Latypova, Xenia ; Başaran, Seher ; Yücel, Esra Börklü ; Tan, Thong Teck ; Vlaminck, Lena ; Nayak, Shalini S. ; Shukla, Anju ; Girisha, Katta Mohan ; Le Caignec, Cédric ; Soshnikova, Natalia ; Uyguner, Zehra Oya ; Vleminckx, Kris ; Barker, Nick ; Kayserili, Hülya ; Reversade, Bruno
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-05, Vol.557 (7706), p.564-569
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ArticlesPeer ReviewedFull Text
Targeted protein degradation: expanding the toolbox
Author / Creator:Schapira, Matthieu ; Calabrese, Matthew F. ; Bullock, Alex N. ; Crews, Craig M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2019-12, Vol.18 (12), p.949-963
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Author / Creator:Doll, Sebastian ; Proneth, Bettina ; Tyurina, Yulia Y ; Panzilius, Elena ; Kobayashi, Sho ; Ingold, Irina ; Irmler, Martin ; Beckers, Johannes ; Aichler, Michaela ; Walch, Axel ; Prokisch, Holger ; Trümbach, Dietrich ; Mao, Gaowei ; Qu, Feng ; Bayir, Hulya ; Füllekrug, Joachim ; Scheel, Christina H ; Wurst, Wolfgang ; Schick, Joel A ; Kagan, Valerian E ; Angeli, José Pedro Friedmann ; Conrad, Marcus
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2017-01, Vol.13 (1), p.91-98
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Author / Creator:Kagan, Valerian E ; Mao, Gaowei ; Qu, Feng ; Angeli, Jose Pedro Friedmann ; Doll, Sebastian ; Croix, Claudette St ; Dar, Haider Hussain ; Liu, Bing ; Tyurin, Vladimir A ; Ritov, Vladimir B ; Kapralov, Alexandr A ; Amoscato, Andrew A ; Jiang, Jianfei ; Anthonymuthu, Tamil ; Mohammadyani, Dariush ; Yang, Qin ; Proneth, Bettina ; Klein-Seetharaman, Judith ; Watkins, Simon ; Bahar, Ivet ; Greenberger, Joel ; Mallampalli, Rama K ; Stockwell, Brent R ; Tyurina, Yulia Y ; Conrad, Marcus ; Bayır, Hülya
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2017-01, Vol.13 (1), p.81-90
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Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion
Author / Creator:Li, Yang ; Feng, Dongcheng ; Wang, Zhanyu ; Zhao, Yan ; Sun, Ruimin ; Tian, Donghai ; Liu, Deshun ; Zhang, Feng ; Ning, Shili ; Yao, Jihong ; Tian, Xiaofeng
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2019-11, Vol.26 (11), p.2284-2299
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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway
Author / Creator:Lee, Yu-Ru ; Chen, Ming ; Lee, Jonathan D. ; Zhang, Jinfang ; Lin, Shu-Yu ; Fu, Tian-Min ; Chen, Hao ; Ishikawa, Tomoki ; Chiang, Shang-Yin ; Katon, Jesse ; Zhang, Yang ; Shulga, Yulia V. ; Bester, Assaf C. ; Fung, Jacqueline ; Monteleone, Emanuele ; Wan, Lixin ; Shen, Chen ; Hsu, Chih-Hung ; Papa, Antonella ; Clohessy, John G. ; Teruya-Feldstein, Julie ; Jain, Suresh ; Wu, Hao ; Matesic, Lydia ; Chen, Ruey-Hwa ; Wei, Wenyi ; Pandolfi, Pier Paolo
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2019-05, Vol.364 (6441), p.651-651
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ArticlesPeer ReviewedFull Text
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
Author / Creator:Fischer, Eric S. ; Böhm, Kerstin ; Lydeard, John R. ; Yang, Haidi ; Stadler, Michael B. ; Cavadini, Simone ; Nagel, Jane ; Serluca, Fabrizio ; Acker, Vincent ; Lingaraju, Gondichatnahalli M. ; Tichkule, Ritesh B. ; Schebesta, Michael ; Forrester, William C. ; Schirle, Markus ; Hassiepen, Ulrich ; Ottl, Johannes ; Hild, Marc ; Beckwith, Rohan E. J. ; Harper, J. Wade ; Jenkins, Jeremy L. ; Thomä, Nicolas H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-08, Vol.512 (7512), p.49-53
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ArticlesPeer ReviewedFull Text
Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface
Author / Creator:Gorelik, Maryna ; Orlicky, Stephen ; Sartori, Maria A. ; Tang, Xiaojing ; Marcon, Edyta ; Kurinov, Igor ; Greenblatt, Jack F. ; Tyers, Mike ; Moffat, Jason ; Sicheri, Frank ; Sidhu, Sachdev S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.3527-3532
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ArticlesPeer ReviewedFull Text
Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
Author / Creator:Sharma, Anmol ; Khan, Heena ; Singh, Thakur ; Grewal, Amarjot ; Najda, Agnieszka ; Kawecka-Radomska, Małgorzata ; Kamel, Mohamed ; Altyar, Ahmed ; Abdel-Daim, Mohamed
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-11, Vol.22 (21), p.11971
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ArticlesPeer ReviewedFull Text
SCF ubiquitin ligase-targeted therapies
Author / Creator:Skaar, Jeffrey R. ; Pagan, Julia K. ; Pagano, Michele
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2014-12, Vol.13 (12), p.889-903
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E3 ubiquitin ligases in cancer and implications for therapies
Author / Creator:Wang, Dong ; Ma, Leina ; Wang, Bin ; Liu, Jia ; Wei, Wenyi
Publisher:New York: Springer US
Journal title:Cancer and metastasis reviews, 2017-12, Vol.36 (4), p.683-702
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ArticlesPeer ReviewedFull Text
Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling
Author / Creator:Shabek, Nitzan ; Ticchiarelli, Fabrizio ; Mao, Haibin ; Hinds, Thomas R. ; Leyser, Ottoline ; Zheng, Ning
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-11, Vol.563 (7733), p.652-656
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ArticlesPeer ReviewedFull Text
Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition
Author / Creator:Koliopoulos, Marios G. ; Lethier, Mathilde ; van der Veen, Annemarthe G. ; Haubrich, Kevin ; Hennig, Janosch ; Kowalinski, Eva ; Stevens, Rebecca V. ; Martin, Stephen R. ; Reis e Sousa, Caetano ; Cusack, Stephen ; Rittinger, Katrin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-05, Vol.9 (1), p.1820-13, Article 1820
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Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI
Author / Creator:Weng, Chien-Hui ; Chen, Li-Yu ; Lin, Yu-Chin ; Shih, Jin-Yuan ; Lin, Yun-Chieh ; Tseng, Ruo-Yu ; Chiu, An-Chieh ; Yeh, Yu-Hsuan ; Liu, Chi ; Lin, Yi-Ting ; Fang, Jim-Min ; Chen, Ching-Chow
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2019-01, Vol.38 (4), p.455-468
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ArticlesPeer ReviewedFull Text
Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma
Author / Creator:Wang, Xin ; Qin, Ge ; Liang, Xiaoting ; Wang, Wen ; Wang, Zhuo ; Liao, Dan ; Zhong, Li ; Zhang, Ruhua ; Zeng, Yi-Xin ; Wu, Yuanzhong ; Kang, Tiebang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-02, Vol.11 (1), p.1141-14, Article 1141
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Arvinas’s PROTACs pass first safety and PK analysis
Author / Creator:Mullard, Asher
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2019-11, Vol.18 (12), p.895-895
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ArticlesPeer ReviewedFull Text
Targeting the ubiquitin system in cancer therapy
Author / Creator:Hoeller, Daniela ; Dikic, Ivan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-03, Vol.458 (7237), p.438-444
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ArticlesPeer ReviewedFull Text
Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin catalysed glutamylation
Author / Creator:Bhogaraju, Sagar ; Bonn, Florian ; Mukherjee, Rukmini ; Adams, Michael ; Pfleiderer, Moritz M. ; Galej, Wojciech P. ; Matkovic, Vigor ; Lopez-Mosqueda, Jaime ; Kalayil, Sissy ; Shin, Donghyuk ; Dikic, Ivan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-08, Vol.572 (7769), p.382-386
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ArticlesPeer ReviewedFull Text
Identification of a Primary Target of Thalidomide Teratogenicity
Author / Creator:Ito, Takumi ; Ando, Hideki ; Suzuki, Takayuki ; Ogura, Toshihiko ; Hotta, Kentaro ; Imamura, Yoshimasa ; Yamaguchi, Yuki ; Handa, Hiroshi
Publisher:Washington, DC: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2010-03, Vol.327 (5971), p.1345-1350
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Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination

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RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

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Targeted protein degradation: expanding the toolbox

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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

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Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

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Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

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Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1–F-box interface

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Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling

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SCF ubiquitin ligase-targeted therapies

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E3 ubiquitin ligases in cancer and implications for therapies

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Structural plasticity of D3–D14 ubiquitin ligase in strigolactone signalling

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Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

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Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI

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Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma

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Arvinas’s PROTACs pass first safety and PK analysis

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Targeting the ubiquitin system in cancer therapy

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Inhibition of bacterial ubiquitin ligases by SidJ–calmodulin catalysed glutamylation

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Identification of a Primary Target of Thalidomide Teratogenicity

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