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628 results for Oligonucleotides,+Antisense+-+genetics

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ArticlesPeer ReviewedFull Text
Antisense technology: an overview and prospectus
Author / Creator:Crooke, Stanley T. ; Baker, Brenda F. ; Crooke, Rosanne M. ; Liang, Xue-hai
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2021-06, Vol.20 (6), p.427-453
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ArticlesPeer ReviewedFull Text
U1 snRNP regulates cancer cell migration and invasion in vitro
Author / Creator:Oh, Jung-Min ; Venters, Christopher C. ; Di, Chao ; Pinto, Anna Maria ; Wan, Lili ; Younis, Ihab ; Cai, Zhiqiang ; Arai, Chie ; So, Byung Ran ; Duan, Jingqi ; Dreyfuss, Gideon
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.1-1, Article 1
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ArticlesPeer ReviewedFull Text
Cellular uptake and trafficking of antisense oligonucleotides
Author / Creator:Crooke, Stanley T ; Wang, Shiyu ; Vickers, Timothy A ; Shen, Wen ; Liang, Xue-hai
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2017-03, Vol.35 (3), p.230-237
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The chemical evolution of oligonucleotide therapies of clinical utility
Author / Creator:Khvorova, Anastasia ; Watts, Jonathan K
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2017-03, Vol.35 (3), p.238-248
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ArticlesPeer ReviewedFull Text
Efficient RNA drug delivery using red blood cell extracellular vesicles
Author / Creator:Usman, Waqas Muhammad ; Pham, Tin Chanh ; Kwok, Yuk Yan ; Vu, Luyen Tien ; Ma, Victor ; Peng, Boya ; Chan, Yuen San ; Wei, Likun ; Chin, Siew Mei ; Azad, Ajijur ; He, Alex Bai-Liang ; Leung, Anskar Y. H. ; Yang, Mengsu ; Shyh-Chang, Ng ; Cho, William C. ; Shi, Jiahai ; Le, Minh T. N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-06, Vol.9 (1), p.2359-15, Article 2359
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Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide
Author / Creator:Tran, Hélène ; Moazami, Michael P. ; Yang, Huiya ; McKenna-Yasek, Diane ; Douthwright, Catherine L. ; Pinto, Courtney ; Metterville, Jake ; Shin, Minwook ; Sanil, Nitasha ; Dooley, Craig ; Puri, Ajit ; Weiss, Alexandra ; Wightman, Nicholas ; Gray-Edwards, Heather ; Marosfoi, Miklos ; King, Robert M. ; Kenderdine, Thomas ; Fabris, Daniele ; Bowser, Robert ; Watts, Jonathan K. ; Brown, Robert H.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2022-01, Vol.28 (1), p.117-124
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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
Author / Creator:Zhang, Ke ; Donnelly, Christopher J. ; Haeusler, Aaron R. ; Grima, Jonathan C. ; Machamer, James B. ; Steinwald, Peter ; Daley, Elizabeth L. ; Miller, Sean J. ; Cunningham, Kathleen M. ; Vidensky, Svetlana ; Gupta, Saksham ; Thomas, Michael A. ; Hong, Ingie ; Chiu, Shu-Ling ; Huganir, Richard L. ; Ostrow, Lyle W. ; Matunis, Michael J. ; Wang, Jiou ; Sattler, Rita ; Lloyd, Thomas E. ; Rothstein, Jeffrey D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2015-09, Vol.525 (7567), p.56-61
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ArticlesPeer ReviewedFull Text
Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides
Author / Creator:Sangermano, Riccardo ; Garanto, Alejandro ; Khan, Mubeen ; Runhart, Esmee H. ; Bauwens, Miriam ; Bax, Nathalie M. ; van den Born, L. Ingeborgh ; Khan, Muhammad Imran ; Cornelis, Stéphanie S. ; Verheij, Joke B. G. M. ; Pott, Jan-Willem R. ; Thiadens, Alberta A. H. J. ; Klaver, Caroline C. W. ; Puech, Bernard ; Meunier, Isabelle ; Naessens, Sarah ; Arno, Gavin ; Fakin, Ana ; Carss, Keren J. ; Raymond, F. Lucy ; Webster, Andrew R. ; Dhaenens, Claire-Marie ; Stöhr, Heidi ; Grassmann, Felix ; Weber, Bernhard H. F. ; Hoyng, Carel B. ; De Baere, Elfride ; Albert, Silvia ; Collin, Rob W. J. ; Cremers, Frans P. M.
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2019-08, Vol.21 (8), p.1751-1760
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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice
Author / Creator:Becker, Lindsay A. ; Huang, Brenda ; Bieri, Gregor ; Ma, Rosanna ; Knowles, David A. ; Jafar-Nejad, Paymaan ; Messing, James ; Kim, Hong Joo ; Soriano, Armand ; Auburger, Georg ; Pulst, Stefan M. ; Taylor, J. Paul ; Rigo, Frank ; Gitler, Aaron D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-04, Vol.544 (7650), p.367-371
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ArticlesPeer ReviewedFull Text
Recent Advances in Oligonucleotide Therapeutics in Oncology
Author / Creator:Xiong, Haoyu ; Veedu, Rakesh N ; Diermeier, Sarah D
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2021-03, Vol.22 (7), p.3295
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ArticlesPeer ReviewedFull Text
Preclinical development of a miR-132 inhibitor for heart failure treatment
Author / Creator:Foinquinos, Ariana ; Batkai, Sandor ; Genschel, Celina ; Viereck, Janika ; Rump, Steffen ; Gyöngyösi, Mariann ; Traxler, Denise ; Riesenhuber, Martin ; Spannbauer, Andreas ; Lukovic, Dominika ; Weber, Natalie ; Zlabinger, Katrin ; Hašimbegović, Ena ; Winkler, Johannes ; Fiedler, Jan ; Dangwal, Seema ; Fischer, Martin ; de la Roche, Jeanne ; Wojciechowski, Daniel ; Kraft, Theresia ; Garamvölgyi, Rita ; Neitzel, Sonja ; Chatterjee, Shambhabi ; Yin, Xiaoke ; Bär, Christian ; Mayr, Manuel ; Xiao, Ke ; Thum, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-01, Vol.11 (1), p.633-10, Article 633
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ArticlesPeer ReviewedFull Text
RNA-targeting and gene editing therapies for transthyretin amyloidosis
Author / Creator:Aimo, Alberto ; Castiglione, Vincenzo ; Rapezzi, Claudio ; Franzini, Maria ; Panichella, Giorgia ; Vergaro, Giuseppe ; Gillmore, Julian ; Fontana, Marianna ; Passino, Claudio ; Emdin, Michele
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews cardiology, 2022-10, Vol.19 (10), p.655-667
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Therapeutic approaches for Duchenne muscular dystrophy
Author / Creator:Roberts, Thomas C. ; Wood, Matthew J. A. ; Davies, Kay E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2023-11, Vol.22 (11), p.917-934
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Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides
Author / Creator:Merkle, Tobias ; Merz, Sarah ; Reautschnig, Philipp ; Blaha, Andreas ; Li, Qin ; Vogel, Paul ; Wettengel, Jacqueline ; Li, Jin Billy ; Stafforst, Thorsten
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2019-02, Vol.37 (2), p.133-138
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ArticlesPeer ReviewedFull Text
ABCA4-associated disease as a model for missing heritability in autosomal recessive disorders: novel noncoding splice, cis-regulatory, structural, and recurrent hypomorphic variants
Author / Creator:Bauwens, Miriam ; Garanto, Alejandro ; Sangermano, Riccardo ; Naessens, Sarah ; Weisschuh, Nicole ; De Zaeytijd, Julie ; Khan, Mubeen ; Sadler, Françoise ; Balikova, Irina ; Van Cauwenbergh, Caroline ; Rosseel, Toon ; Bauwens, Jim ; De Leeneer, Kim ; De Jaegere, Sarah ; Van Laethem, Thalia ; De Vries, Meindert ; Carss, Keren ; Arno, Gavin ; Fakin, Ana ; Webster, Andrew R. ; de Ravel de l’Argentière, Thomy J. L. ; Sznajer, Yves ; Vuylsteke, Marnik ; Kohl, Susanne ; Wissinger, Bernd ; Cherry, Timothy ; Collin, Rob W. J. ; Cremers, Frans P. M. ; Leroy, Bart P. ; De Baere, Elfride
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2019-08, Vol.21 (8), p.1761-1771
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ArticlesPeer ReviewedFull Text
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration
Author / Creator:Lagier-Tourenne, Clotilde ; Baughn, Michael ; Rigo, Frank ; Sun, Shuying ; Liu, Patrick ; Li, Hai-Ri ; Jiang, Jie ; Watt, Andrew T ; Chun, Seung ; Katz, Melanie ; Qiu, Jinsong ; Sun, Ying ; Ling, Shuo-Chien ; Zhu, Qiang ; Polymenidou, Magdalini ; Drenner, Kevin ; Artates, Jonathan W ; McAlonis-Downes, Melissa ; Markmiller, Sebastian ; Hutt, Kasey R ; Pizzo, Donald P ; Cady, Janet ; Harms, Matthew B ; Baloh, Robert H ; Vandenberg, Scott R ; Yeo, Gene W ; Fu, Xiang-Dong ; Bennett, C Frank ; Cleveland, Don W ; Ravits, John
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.E4530-E4539
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ArticlesPeer ReviewedFull Text
Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome
Author / Creator:Zhang, Kaiming ; Zheludev, Ivan N. ; Hagey, Rachel J. ; Haslecker, Raphael ; Hou, Yixuan J. ; Kretsch, Rachael ; Pintilie, Grigore D. ; Rangan, Ramya ; Kladwang, Wipapat ; Li, Shanshan ; Wu, Marie Teng-Pei ; Pham, Edward A. ; Bernardin-Souibgui, Claire ; Baric, Ralph S. ; Sheahan, Timothy P. ; D’Souza, Victoria ; Glenn, Jeffrey S. ; Chiu, Wah ; Das, Rhiju
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2021-09, Vol.28 (9), p.747-754
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ArticlesPeer ReviewedFull Text
Development of microRNA therapeutics is coming of age
Author / Creator:van Rooij, Eva ; Kauppinen, Sakari
Publisher:London: Nature Publishing Group UK
Journal title:EMBO molecular medicine, 2014-07, Vol.6 (7), p.851-864
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ArticlesPeer ReviewedFull Text
RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19
Author / Creator:Alafeef, Maha ; Moitra, Parikshit ; Dighe, Ketan ; Pan, Dipanjan
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2021-06, Vol.16 (6), p.3141-3162
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ArticlesPeer ReviewedFull Text
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
Author / Creator:Michelini, Flavia ; Pitchiaya, Sethuramasundaram ; Vitelli, Valerio ; Sharma, Sheetal ; Gioia, Ubaldo ; Pessina, Fabio ; Cabrini, Matteo ; Wang, Yejun ; Capozzo, Ilaria ; Iannelli, Fabio ; Matti, Valentina ; Francia, Sofia ; Shivashankar, G. V. ; Walter, Nils G. ; d’Adda di Fagagna, Fabrizio
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2017-12, Vol.19 (12), p.1400-1411
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Antisense technology: an overview and prospectus

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U1 snRNP regulates cancer cell migration and invasion in vitro

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Cellular uptake and trafficking of antisense oligonucleotides

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The chemical evolution of oligonucleotide therapies of clinical utility

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Efficient RNA drug delivery using red blood cell extracellular vesicles

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Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

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The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

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Deep-intronic ABCA4 variants explain missing heritability in Stargardt disease and allow correction of splice defects by antisense oligonucleotides

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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

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Recent Advances in Oligonucleotide Therapeutics in Oncology

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Preclinical development of a miR-132 inhibitor for heart failure treatment

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RNA-targeting and gene editing therapies for transthyretin amyloidosis

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Therapeutic approaches for Duchenne muscular dystrophy

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Precise RNA editing by recruiting endogenous ADARs with antisense oligonucleotides

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ABCA4-associated disease as a model for missing heritability in autosomal recessive disorders: novel noncoding splice, cis-regulatory, structural, and recurrent hypomorphic variants

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Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

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Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

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Development of microRNA therapeutics is coming of age

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RNA-extraction-free nano-amplified colorimetric test for point-of-care clinical diagnosis of COVID-19

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Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks

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