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258 results for Poly+(ADP-Ribose)+Polymerase-1+-+genetics

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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease
Author / Creator:Kam, Tae-In ; Mao, Xiaobo ; Park, Hyejin ; Chou, Shih-Ching ; Karuppagounder, Senthilkumar S. ; Umanah, George Essien ; Yun, Seung Pil ; Brahmachari, Saurav ; Panicker, Nikhil ; Chen, Rong ; Andrabi, Shaida A. ; Qi, Chen ; Poirier, Guy G. ; Pletnikova, Olga ; Troncoso, Juan C. ; Bekris, Lynn M. ; Leverenz, James B. ; Pantelyat, Alexander ; Ko, Han Seok ; Rosenthal, Liana S. ; Dawson, Ted M. ; Dawson, Valina L.
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-11, Vol.362 (6414)
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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
Author / Creator:Pettitt, Stephen J. ; Krastev, Dragomir B. ; Brandsma, Inger ; Dréan, Amy ; Song, Feifei ; Aleksandrov, Radoslav ; Harrell, Maria I. ; Menon, Malini ; Brough, Rachel ; Campbell, James ; Frankum, Jessica ; Ranes, Michael ; Pemberton, Helen N. ; Rafiq, Rumana ; Fenwick, Kerry ; Swain, Amanda ; Guettler, Sebastian ; Lee, Jung-Min ; Swisher, Elizabeth M. ; Stoynov, Stoyno ; Yusa, Kosuke ; Ashworth, Alan ; Lord, Christopher J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-05, Vol.9 (1), p.1849-14, Article 1849
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PARP inhibition impedes the maturation of nascent DNA strands during DNA replication
Author / Creator:Vaitsiankova, Alina ; Burdova, Kamila ; Sobol, Margarita ; Gautam, Amit ; Benada, Oldrich ; Hanzlikova, Hana ; Caldecott, Keith W.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2022-04, Vol.29 (4), p.329-338
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PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer
Author / Creator:Chabanon, Roman M. ; Muirhead, Gareth ; Krastev, Dragomir B. ; Adam, Julien ; Morel, Daphné ; Garrido, Marlène ; Lamb, Andrew ; Hénon, Clémence ; Dorvault, Nicolas ; Rouanne, Mathieu ; Marlow, Rebecca ; Bajrami, Ilirjana ; Cardeñosa, Marta Llorca ; Konde, Asha ; Besse, Benjamin ; Ashworth, Alan ; Pettitt, Stephen J. ; Haider, Syed ; Marabelle, Aurélien ; Tutt, Andrew N.J. ; Soria, Jean-Charles ; Lord, Christopher J. ; Postel-Vinay, Sophie
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2019-03, Vol.129 (3), p.1211-1228
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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
Author / Creator:Zimmermann, Michal ; Murina, Olga ; Reijns, Martin A. M. ; Agathanggelou, Angelo ; Challis, Rachel ; Tarnauskaitė, Žygimantė ; Muir, Morwenna ; Fluteau, Adeline ; Aregger, Michael ; McEwan, Andrea ; Yuan, Wei ; Clarke, Matthew ; Lambros, Maryou B. ; Paneesha, Shankara ; Moss, Paul ; Chandrashekhar, Megha ; Angers, Stephane ; Moffat, Jason ; Brunton, Valerie G. ; Hart, Traver ; de Bono, Johann ; Stankovic, Tatjana ; Jackson, Andrew P. ; Durocher, Daniel
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-07, Vol.559 (7713), p.285-289
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PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation
Author / Creator:Ronson, George E. ; Piberger, Ann Liza ; Higgs, Martin R. ; Olsen, Anna L. ; Stewart, Grant S. ; McHugh, Peter J. ; Petermann, Eva ; Lakin, Nicholas D.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-02, Vol.9 (1), p.746-12, Article 746
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Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1
Author / Creator:Hsu, En-Chi ; Rice, Meghan A. ; Bermudez, Abel ; Marques, Fernando Jose Garcia ; Aslan, Merve ; Liu, Shiqin ; Ghoochani, Ali ; Zhang, Chiyuan Amy ; Chen, Yun-Sheng ; Zlitni, Aimen ; Kumar, Sahil ; Nolley, Rosalie ; Habte, Frezghi ; Shen, Michelle ; Koul, Kashyap ; Peehl, Donna M. ; Zoubeidi, Amina ; Gambhir, Sanjiv S. ; Kunder, Christian A. ; Pitteri, Sharon J. ; Brooks, James D. ; Stoyanova, Tanya
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-01, Vol.117 (4), p.2032-2042
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METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability
Author / Creator:Li, Huafu ; Wang, Chunming ; Lan, Linxiang ; Yan, Leping ; Li, Wuguo ; Evans, Ian ; Ruiz, E. Josue ; Su, Qiao ; Zhao, Guangying ; Wu, Wenhui ; Zhang, Haiyong ; Zhou, Zhijun ; Hu, Zhenran ; Chen, Wei ; Oliveira, Joaquim M. ; Behrens, Axel ; Reis, Rui L. ; Zhang, Changhua
Publisher:Cham: Springer International Publishing
Journal title:Cellular and molecular life sciences : CMLS, 2022-03, Vol.79 (3), p.135-135, Article 135
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Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2
Author / Creator:Wang, Cheng ; Xu, Wenjing ; An, Jie ; Liang, Minglu ; Li, Yiqing ; Zhang, Fengxiao ; Tong, Qiangsong ; Huang, Kai
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-03, Vol.10 (1), p.1203-12, Article 1203
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A PET imaging agent for evaluating PARP-1 expression in ovarian cancer
Author / Creator:Makvandi, Mehran ; Pantel, Austin ; Schwartz, Lauren ; Schubert, Erin ; Xu, Kuiying ; Hsieh, Chia-Ju ; Hou, Catherine ; Kim, Hyoung ; Weng, Chi-Chang ; Winters, Harrison ; Doot, Robert ; Farwell, Michael D. ; Pryma, Daniel A. ; Greenberg, Roger A. ; Mankoff, David A. ; Simpkins, Fiona ; Mach, Robert H. ; Lin, Lilie L.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-05, Vol.128 (5), p.2116-2126
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HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications
Author / Creator:Langelier, Marie-France ; Billur, Ramya ; Sverzhinsky, Aleksandr ; Black, Ben E. ; Pascal, John M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-11, Vol.12 (1), p.6675-6675, Article 6675
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HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage
Author / Creator:Smith, Rebecca ; Zentout, Siham ; Rother, Magdalena ; Bigot, Nicolas ; Chapuis, Catherine ; Mihuț, Alexandra ; Zobel, Florian Franz ; Ahel, Ivan ; van Attikum, Haico ; Timinszky, Gyula ; Huet, Sébastien
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2023-05, Vol.30 (5), p.678-691
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A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging
Author / Creator:Li, Jun ; Bonkowski, Michael S. ; Moniot, Sébastien ; Zhang, Dapeng ; Hubbard, Basil P. ; Ling, Alvin J. Y. ; Rajman, Luis A. ; Qin, Bo ; Lou, Zhenkun ; Gorbunova, Vera ; Aravind, L. ; Steegborn, Clemens ; Sinclair, David A.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2017-03, Vol.355 (6331), p.1312-1317
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XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
Author / Creator:Hoch, Nicolas C. ; Hanzlikova, Hana ; Rulten, Stuart L. ; Tétreault, Martine ; Komulainen, Emilia ; Ju, Limei ; Hornyak, Peter ; Zeng, Zhihong ; Gittens, William ; Rey, Stephanie A. ; Staras, Kevin ; Mancini, Grazia M. S. ; McKinnon, Peter J. ; Wang, Zhao-Qi ; Wagner, Justin D. ; Yoon, Grace ; Caldecott, Keith W.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-01, Vol.541 (7635), p.87-91
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Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function
Author / Creator:Gui, Bin ; Gui, Fu ; Takai, Tomoaki ; Feng, Chao ; Bai, Xiao ; Fazli, Ladan ; Dong, Xuesen ; Liu, Shuai ; Zhang, Xiaofeng ; Zhang, Wei ; Kibel, Adam S. ; Jia, Li
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (29), p.14573-14582
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The kinase polypharmacology landscape of clinical PARP inhibitors
Author / Creator:Antolin, Albert A. ; Ameratunga, Malaka ; Banerji, Udai ; Clarke, Paul A. ; Workman, Paul ; Al-Lazikani, Bissan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-02, Vol.10 (1), p.2585, Article 2585
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Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy
Author / Creator:Krüger, Annika ; Bürkle, Alexander ; Hauser, Karin ; Mangerich, Aswin
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2174-15, Article 2174
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An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer
Author / Creator:Powles, Thomas ; Carroll, Danielle ; Chowdhury, Simon ; Gravis, Gwenaelle ; Joly, Florence ; Carles, Joan ; Fléchon, Aude ; Maroto, Pablo ; Petrylak, Daniel ; Rolland, Frédéric ; Cook, Natalie ; Balar, Arjun V. ; Sridhar, Srikala S. ; Galsky, Matthew D. ; Grivas, Petros ; Ravaud, Alain ; Jones, Robert ; Cosaert, Jan ; Hodgson, Darren ; Kozarewa, Iwanka ; Mather, Richard ; McEwen, Robert ; Mercier, Florence ; Landers, Dónal
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2021-05, Vol.27 (5), p.793-801
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Genetic screens in isogenic mammalian cell lines without single cell cloning
Author / Creator:DeWeirdt, Peter C. ; Sangree, Annabel K. ; Hanna, Ruth E. ; Sanson, Kendall R. ; Hegde, Mudra ; Strand, Christine ; Persky, Nicole S. ; Doench, John G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-02, Vol.11 (1), p.752-15, Article 752
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DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
Author / Creator:Zhang, Deli ; Hu, Xu ; Li, Jin ; Liu, Jia ; Baks-te Bulte, Luciënne ; Wiersma, Marit ; Malik, Noor-ul-Ann ; van Marion, Denise M. S. ; Tolouee, Marziyeh ; Hoogstra-Berends, Femke ; Lanters, Eva A. H. ; van Roon, Arie M. ; de Vries, Antoine A. F. ; Pijnappels, Daniël A. ; de Groot, Natasja M. S. ; Henning, Robert H. ; Brundel, Bianca J. J. M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-03, Vol.10 (1), p.1307-17, Article 1307
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Showing 1 to 20 of 258 results

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Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance

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PARP inhibition impedes the maturation of nascent DNA strands during DNA replication

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PARP inhibition enhances tumor cell–intrinsic immunity in ERCC1-deficient non–small cell lung cancer

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CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions

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PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

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Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1

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METTL3 promotes oxaliplatin resistance of gastric cancer CD133+ stem cells by promoting PARP1 mRNA stability

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Poly(ADP-ribose) polymerase 1 accelerates vascular calcification by upregulating Runx2

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A PET imaging agent for evaluating PARP-1 expression in ovarian cancer

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HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

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HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage

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A conserved NAD⁺ binding pocket that regulates protein-protein interactions during aging

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XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia

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Selective targeting of PARP-2 inhibits androgen receptor signaling and prostate cancer growth through disruption of FOXA1 function

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The kinase polypharmacology landscape of clinical PARP inhibitors

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Real-time monitoring of PARP1-dependent PARylation by ATR-FTIR spectroscopy

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An adaptive, biomarker-directed platform study of durvalumab in combination with targeted therapies in advanced urothelial cancer

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Genetic screens in isogenic mammalian cell lines without single cell cloning

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DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation

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