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967 results for Quinolones+-+pharmacology

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Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance
Author / Creator:Bush, Natassja G. ; Diez-Santos, Isabel ; Abbott, Lauren R. ; Maxwell, Anthony
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2020-12, Vol.25 (23), p.5662
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Predictive compound accumulation rules yield a broad-spectrum antibiotic
Author / Creator:Richter, Michelle F. ; Drown, Bryon S. ; Riley, Andrew P. ; Garcia, Alfredo ; Shirai, Tomohiro ; Svec, Riley L. ; Hergenrother, Paul J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-05, Vol.545 (7654), p.299-304
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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours
Author / Creator:Xu, Hong ; Di Antonio, Marco ; McKinney, Steven ; Mathew, Veena ; Ho, Brandon ; O’Neil, Nigel J. ; Santos, Nancy Dos ; Silvester, Jennifer ; Wei, Vivien ; Garcia, Jessica ; Kabeer, Farhia ; Lai, Daniel ; Soriano, Priscilla ; Banáth, Judit ; Chiu, Derek S. ; Yap, Damian ; Le, Daniel D. ; Ye, Frank B. ; Zhang, Anni ; Thu, Kelsie ; Soong, John ; Lin, Shu-chuan ; Tsai, Angela Hsin Chin ; Osako, Tomo ; Algara, Teresa ; Saunders, Darren N. ; Wong, Jason ; Xian, Jian ; Bally, Marcel B. ; Brenton, James D. ; Brown, Grant W. ; Shah, Sohrab P. ; Cescon, David ; Mak, Tak W. ; Caldas, Carlos ; Stirling, Peter C. ; Hieter, Phil ; Balasubramanian, Shankar ; Aparicio, Samuel
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-02, Vol.8 (1), p.14432-18, Article 14432
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Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms
Author / Creator:Turnbull, Lynne ; Toyofuku, Masanori ; Hynen, Amelia L. ; Kurosawa, Masaharu ; Pessi, Gabriella ; Petty, Nicola K. ; Osvath, Sarah R. ; Cárcamo-Oyarce, Gerardo ; Gloag, Erin S. ; Shimoni, Raz ; Omasits, Ulrich ; Ito, Satoshi ; Yap, Xinhui ; Monahan, Leigh G. ; Cavaliere, Rosalia ; Ahrens, Christian H. ; Charles, Ian G. ; Nomura, Nobuhiko ; Eberl, Leo ; Whitchurch, Cynthia B.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-04, Vol.7 (1), p.11220-11220, Article 11220
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Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis
Author / Creator:Rowe, Steven M ; Daines, Cori ; Ringshausen, Felix C ; Kerem, Eitan ; Wilson, John ; Tullis, Elizabeth ; Nair, Nitin ; Simard, Christopher ; Han, Linda ; Ingenito, Edward P ; McKee, Charlotte ; Lekstrom-Himes, Julie ; Davies, Jane C
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2017-11, Vol.377 (21), p.2024-2035
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A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation
Author / Creator:Ramsey, Bonnie W ; Davies, Jane ; McElvaney, N. Gerard ; Tullis, Elizabeth ; Bell, Scott C ; Dřevínek, Pavel ; Griese, Matthias ; McKone, Edward F ; Wainwright, Claire E ; Konstan, Michael W ; Moss, Richard ; Ratjen, Felix ; Sermet-Gaudelus, Isabelle ; Rowe, Steven M ; Dong, Qunming ; Rodriguez, Sally ; Yen, Karl ; Ordoñez, Claudia ; Elborn, J. Stuart
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2011-11, Vol.365 (18), p.1663-1672
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Sustained Benefit from Ivacaftor Demonstrated by Combining Clinical Trial and Cystic Fibrosis Patient Registry Data
Author / Creator:Sawicki, Gregory S. ; McKone, Edward F. ; Pasta, David J. ; Millar, Stefanie J. ; Wagener, Jeffrey S. ; Johnson, Charles A. ; Konstan, Michael W.
Publisher:United States: American Thoracic Society
Journal title:American journal of respiratory and critical care medicine, 2015-10, Vol.192 (7), p.836-842
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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum
Author / Creator:Zaheer, Rahat ; Cook, Shaun R. ; Barbieri, Ruth ; Goji, Noriko ; Cameron, Andrew ; Petkau, Aaron ; Polo, Rodrigo Ortega ; Tymensen, Lisa ; Stamm, Courtney ; Song, Jiming ; Hannon, Sherry ; Jones, Tineke ; Church, Deirdre ; Booker, Calvin W. ; Amoako, Kingsley ; Van Domselaar, Gary ; Read, Ron R. ; McAllister, Tim A.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-03, Vol.10 (1), p.3937, Article 3937
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Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis
Author / Creator:Rowe, Steven M. ; Heltshe, Sonya L. ; Gonska, Tanja ; Donaldson, Scott H. ; Borowitz, Drucy ; Gelfond, Daniel ; Sagel, Scott D. ; Khan, Umer ; Mayer-Hamblett, Nicole ; Van Dalfsen, Jill M. ; Joseloff, Elizabeth ; Ramsey, Bonnie W.
Publisher:United States: American Thoracic Society
Journal title:American journal of respiratory and critical care medicine, 2014-07, Vol.190 (2), p.175-184
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Dolutegravir in Antiretroviral-Experienced Patients With Raltegravir- and/or Elvitegravir-Resistant HIV-1: 24-Week Results of the Phase III VIKING-3 Study
Author / Creator:Castagna, Antonella ; Maggiolo, Franco ; Penco, Giovanni ; Wright, David ; Mills, Anthony ; Grossberg, Robert ; Molina, Jean-Michel ; Chas, Julie ; Durant, Jacques ; Moreno, Santiago ; Doroana, Manuela ; Ait-Khaled, Mounir ; Huang, Jenny ; Min, Sherene ; Song, Ivy ; Vavro, Cindy ; Nichols, Garrett ; Yeo, Jane M.
Publisher:Oxford: Oxford University Press
Journal title:The Journal of infectious diseases, 2014-08, Vol.210 (3), p.354-362
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How antibiotics kill bacteria: from targets to networks
Author / Creator:Kohanski, Michael A. ; Dwyer, Daniel J. ; Collins, James J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Microbiology, 2010-06, Vol.8 (6), p.423-435
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Optical control of antibacterial activity
Author / Creator:Velema, Willem A. ; van der Berg, Jan Pieter ; Hansen, Mickel J. ; Szymanski, Wiktor ; Driessen, Arnold J. M. ; Feringa, Ben L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2013-11, Vol.5 (11), p.924-928
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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo
Author / Creator:Nakamori, Masayuki ; Panigrahi, Gagan B. ; Lanni, Stella ; Gall-Duncan, Terence ; Hayakawa, Hideki ; Tanaka, Hana ; Luo, Jennifer ; Otabe, Takahiro ; Li, Jinxing ; Sakata, Akihiro ; Caron, Marie-Christine ; Joshi, Niraj ; Prasolava, Tanya ; Chiang, Karen ; Masson, Jean-Yves ; Wold, Marc S. ; Wang, Xiaoxiao ; Lee, Marietta Y. W. T. ; Huddleston, John ; Munson, Katherine M. ; Davidson, Scott ; Layeghifard, Mehdi ; Edward, Lisa-Monique ; Gallon, Richard ; Santibanez-Koref, Mauro ; Murata, Asako ; Takahashi, Masanori P. ; Eichler, Evan E. ; Shlien, Adam ; Nakatani, Kazuhiko ; Mochizuki, Hideki ; Pearson, Christopher E.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2020-02, Vol.52 (2), p.146-159
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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
Author / Creator:Hluchý, Milan ; Gajdušková, Pavla ; Ruiz de los Mozos, Igor ; Rájecký, Michal ; Kluge, Michael ; Berger, Benedict-Tilman ; Slabá, Zuzana ; Potěšil, David ; Weiß, Elena ; Ule, Jernej ; Zdráhal, Zbyněk ; Knapp, Stefan ; Paruch, Kamil ; Friedel, Caroline C. ; Blazek, Dalibor
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-09, Vol.609 (7928), p.829-834
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Cryptic prophages help bacteria cope with adverse environments
Author / Creator:Wang, Xiaoxue ; Kim, Younghoon ; Ma, Qun ; Hong, Seok Hoon ; Pokusaeva, Karina ; Sturino, Joseph M. ; Wood, Thomas K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2010-12, Vol.1 (1), p.147-147, Article 147
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Elexacaftor/Ivacaftor/Tezacaftor: First Approval
Author / Creator:Hoy, Sheridan M.
Publisher:Cham: Springer International Publishing
Journal title:Drugs (New York, N.Y.), 2019-12, Vol.79 (18), p.2001-2007
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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770
Author / Creator:Van Goor, Fredrick ; Hadida, Sabine ; Grootenhuis, Peter D.J ; Burton, Bill ; Cao, Dong ; Neuberger, Tim ; Turnbull, Amanda ; Singh, Ashvani ; Joubran, John ; Hazlewood, Anna ; Zhou, Jinglan ; McCartney, Jason ; Arumugam, Vijayalaksmi ; Decker, Caroline ; Yang, Jennifer ; Young, Chris ; Olson, Eric R ; Wine, Jeffery J ; Frizzell, Raymond A ; Ashlock, Melissa ; Negulescu, Paul
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18825-18830
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Otitis media
Author / Creator:Schilder, Anne G. M. ; Chonmaitree, Tasnee ; Cripps, Allan W. ; Rosenfeld, Richard M. ; Casselbrant, Margaretha L. ; Haggard, Mark P. ; Venekamp, Roderick P.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Disease primers, 2016-09, Vol.2 (1), p.16063-16063, Article 16063
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Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance
Author / Creator:Okamoto, Masanori ; Peterson, Francis C. ; Defries, Andrew ; Park, Sang-Youl ; Endo, Akira ; Nambara, Eiji ; Volkman, Brian F. ; Cutler, Sean R.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.12132-12137
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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension
Author / Creator:Savai, Rajkumar ; Al-Tamari, Hamza M ; Sedding, Daniel ; Kojonazarov, Baktybek ; Muecke, Christian ; Teske, Rebecca ; Capecchi, Mario R ; Weissmann, Norbert ; Grimminger, Friedrich ; Seeger, Werner ; Schermuly, Ralph Theo ; Pullamsetti, Soni Savai
Publisher:London: Nature Publishing Group UK
Journal title:Nature medicine, 2014-11, Vol.20 (11), p.1289-1300
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Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance

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Predictive compound accumulation rules yield a broad-spectrum antibiotic

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CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

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Explosive cell lysis as a mechanism for the biogenesis of bacterial membrane vesicles and biofilms

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Tezacaftor–Ivacaftor in Residual-Function Heterozygotes with Cystic Fibrosis

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A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation

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Sustained Benefit from Ivacaftor Demonstrated by Combining Clinical Trial and Cystic Fibrosis Patient Registry Data

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Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum

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Clinical Mechanism of the Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor in G551D-mediated Cystic Fibrosis

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Dolutegravir in Antiretroviral-Experienced Patients With Raltegravir- and/or Elvitegravir-Resistant HIV-1: 24-Week Results of the Phase III VIKING-3 Study

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How antibiotics kill bacteria: from targets to networks

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Optical control of antibacterial activity

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A slipped-CAG DNA-binding small molecule induces trinucleotide-repeat contractions in vivo

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CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1

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Cryptic prophages help bacteria cope with adverse environments

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Elexacaftor/Ivacaftor/Tezacaftor: First Approval

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Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

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Otitis media

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Activation of dimeric ABA receptors elicits guard cell closure, ABA-regulated gene expression, and drought tolerance

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Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

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