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SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
Author / Creator:Olagnier, David ; Farahani, Ensieh ; Thyrsted, Jacob ; Blay-Cadanet, Julia ; Herengt, Angela ; Idorn, Manja ; Hait, Alon ; Hernaez, Bruno ; Knudsen, Alice ; Iversen, Marie Beck ; Schilling, Mirjam ; Jørgensen, Sofie E. ; Thomsen, Michelle ; Reinert, Line S. ; Lappe, Michael ; Hoang, Huy-Dung ; Gilchrist, Victoria H. ; Hansen, Anne Louise ; Ottosen, Rasmus ; Nielsen, Camilla G. ; Møller, Charlotte ; van der Horst, Demi ; Peri, Suraj ; Balachandran, Siddharth ; Huang, Jinrong ; Jakobsen, Martin ; Svenningsen, Esben B. ; Poulsen, Thomas B. ; Bartsch, Lydia ; Thielke, Anne L. ; Luo, Yonglun ; Alain, Tommy ; Rehwinkel, Jan ; Alcamí, Antonio ; Hiscott, John ; Mogensen, Trine H. ; Paludan, Søren R. ; Holm, Christian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-10, Vol.11 (1), p.4938-4938, Article 4938
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Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
Author / Creator:Chen, Lei-Lei ; Morcelle, Carmen ; Cheng, Zhou-Li ; Chen, Xiufei ; Xu, Yanping ; Gao, Yajing ; Song, Junbin ; Li, Zhijun ; Smith, Matthew D. ; Shi, Miao ; Zhu, Yezhang ; Zhou, Neng ; Cheng, Meng ; He, Chenxi ; Liu, Kwei‐Yan ; Lu, Guoping ; Zhang, Lei ; Zhang, Cheng ; Zhang, Jinye ; Sun, Yiping ; Qi, Tuan ; Lyu, Yingying ; Ren, Zhi-Zhong ; Tan, Xian-Ming ; Yin, Jiayong ; Lan, Fei ; Liu, Ying ; Yang, Hui ; Qian, Maoxiang ; Duan, Caiwen ; Chang, Xing ; Zhou, Yufeng ; Shen, Li ; Baldwin, Albert S. ; Guan, Kun-Liang ; Xiong, Yue ; Ye, Dan
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2022-03, Vol.24 (3), p.353-363
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4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
Author / Creator:Liao, Shan-Ting ; Han, Chao ; Xu, Ding-Qiao ; Fu, Xiao-Wei ; Wang, Jun-Song ; Kong, Ling-Yi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-11, Vol.10 (1), p.5091-11, Article 5091
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Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
Author / Creator:Bambouskova, Monika ; Gorvel, Laurent ; Lampropoulou, Vicky ; Sergushichev, Alexey ; Loginicheva, Ekaterina ; Johnson, Kendall ; Korenfeld, Daniel ; Mathyer, Mary Elizabeth ; Kim, Hyeryun ; Huang, Li-Hao ; Duncan, Dustin ; Bregman, Howard ; Keskin, Abdurrahman ; Santeford, Andrea ; Apte, Rajendra S. ; Sehgal, Raghav ; Johnson, Britney ; Amarasinghe, Gaya K. ; Soares, Miguel P. ; Satoh, Takashi ; Akira, Shizuo ; Hai, Tsonwin ; de Guzman Strong, Cristina ; Auclair, Karine ; Roddy, Thomas P. ; Biller, Scott A. ; Jovanovic, Marko ; Klechevsky, Eynav ; Stewart, Kelly M. ; Randolph, Gwendalyn J. ; Artyomov, Maxim N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-04, Vol.556 (7702), p.501-504
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The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response
Author / Creator:Zeng, Yi-Rong ; Song, Jun-Bin ; Wang, Dezheng ; Huang, Zi-Xuan ; Zhang, Cheng ; Sun, Yi-Ping ; Shu, Gang ; Xiong, Yue ; Guan, Kun-Liang ; Ye, Dan ; Wang, Pu
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2023-03, Vol.133 (6), p.1-11
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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
Author / Creator:Olagnier, David ; Brandtoft, Aske M. ; Gunderstofte, Camilla ; Villadsen, Nikolaj L. ; Krapp, Christian ; Thielke, Anne L. ; Laustsen, Anders ; Peri, Suraj ; Hansen, Anne Louise ; Bonefeld, Lene ; Thyrsted, Jacob ; Bruun, Victor ; Iversen, Marie B. ; Lin, Lin ; Artegoitia, Virginia M. ; Su, Chenhe ; Yang, Long ; Lin, Rongtuan ; Balachandran, Siddharth ; Luo, Yonglun ; Nyegaard, Mette ; Marrero, Bernadette ; Goldbach-Mansky, Raphaela ; Motwani, Mona ; Ryan, Dylan G. ; Fitzgerald, Katherine A. ; O’Neill, Luke A. ; Hollensen, Anne K. ; Damgaard, Christian K. ; de Paoli, Frank v. ; Bertram, Hanne C. ; Jakobsen, Martin R. ; Poulsen, Thomas B. ; Holm, Christian K.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-08, Vol.9 (1), p.3506-13, Article 3506
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Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming
Author / Creator:Aso, Kuniyuki ; Kono, Michihito ; Kanda, Masatoshi ; Kudo, Yuki ; Sakiyama, Kodai ; Hisada, Ryo ; Karino, Kohei ; Ueda, Yusho ; Nakazawa, Daigo ; Fujieda, Yuichiro ; Kato, Masaru ; Amengual, Olga ; Atsumi, Tatsuya
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-02, Vol.14 (1), p.984-984, Article 984
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ArticlesPeer ReviewedFull Text
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
Author / Creator:Tomlinson, Kira L. ; Lung, Tania Wong Fok ; Dach, Felix ; Annavajhala, Medini K. ; Gabryszewski, Stanislaw J. ; Groves, Ryan A. ; Drikic, Marija ; Francoeur, Nancy J. ; Sridhar, Shwetha H. ; Smith, Melissa L. ; Khanal, Sara ; Britto, Clemente J. ; Sebra, Robert ; Lewis, Ian ; Uhlemann, Anne-Catrin ; Kahl, Barbara C. ; Prince, Alice S. ; Riquelme, Sebastián A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1399-13, Article 1399
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ArticlesPeer ReviewedFull Text
Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion
Author / Creator:Gu, Xuemei ; Wei, Haoran ; Suo, Caixia ; Shen, Shengqi ; Zhu, Chuxu ; Chen, Liang ; Yan, Kai ; Li, Zhikun ; Bian, Zhenhua ; Zhang, Pinggen ; Yuan, Mengqiu ; Yu, Yingxuan ; Du, Jinzhi ; Zhang, Huafeng ; Sun, Linchong ; Gao, Ping
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-12, Vol.14 (1), p.8154-8154, Article 8154
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ArticlesPeer ReviewedFull Text
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
Author / Creator:Sohail, Aaqib ; Iqbal, Azeem A. ; Sahini, Nishika ; Chen, Fangfang ; Tantawy, Mohamed ; Waqas, Syed F.H. ; Winterhoff, Moritz ; Ebensen, Thomas ; Schultz, Kristin ; Geffers, Robert ; Schughart, Klaus ; Preusse, Matthias ; Shehata, Mahmoud ; Bähre, Heike ; Pils, Marina C. ; Guzman, Carlos A. ; Mostafa, Ahmed ; Pleschka, Stephan ; Falk, Christine ; Michelucci, Alessandro ; Pessler, Frank
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2022-01, Vol.18 (1), p.e1010219-e1010219
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ArticlesPeer ReviewedFull Text
Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis
Author / Creator:Kuo, Ping-Chang ; Weng, Wen-Tsan ; Scofield, Barbara A. ; Paraiso, Hallel C. ; Brown, Dennis A. ; Wang, Pei-Yu ; Yu, I-Chen ; Yen, Jui-Hung
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2020-04, Vol.17 (1), p.138-138, Article 138
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Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS
Author / Creator:Zhu, Xiaoyang ; Guo, Yangyang ; Liu, Zhigang ; Yang, Jingyi ; Tang, Huiru ; Wang, Yulan
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-09, Vol.11 (1), p.18173-18173, Article 18173
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Itaconate: A Potent Macrophage Immunomodulator: Itaconate: A Potent Macrophage Immunomodulator
Author / Creator:Li, Zeyu ; Zheng, Wenbin ; Kong, Wen ; Zeng, Tianshu
Publisher:New York: Springer US
Journal title:Inflammation, 2023-08, Vol.46 (4), p.1177-1191
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Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis
Author / Creator:Kong, Xiangyi ; Lyu, Wenyuan ; Lin, Xiaojie ; Lin, Chunlong ; Feng, Hao ; Xu, Lin ; Shan, Kaiyue ; Wei, Penghui ; Li, Jianjun
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2024-04, Vol.21 (1), p.104-104, Article 104
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4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling : 4-Octyl itaconate alleviates endothelial dysfunction
Author / Creator:Li, Rong ; Ma, Yu ; Wu, Haoran ; Zhang, Xiao ; Ding, Nianhui ; Li, Zhichao ; Hu, Xin ; Rao, Jiajia ; Zhou, Yiting ; Wang, Liqun ; Wan, Ying ; Yang, Yan ; Wu, Jianbo ; Zhang, Xiaoqin ; Zhang, Chunxiang
Publisher:England: BioMed Central
Journal title:Molecular medicine (Cambridge, Mass.), 2025-06, Vol.31 (1), p.240
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Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis
Author / Creator:Kachler, Katerina ; Andreev, Darja ; Thapa, Shreeya ; Royzman, Dmytro ; Gießl, Andreas ; Karuppusamy, Shobika ; Llerins Perez, Mireia ; Liu, Mengdan ; Hofmann, Jörg ; Gessner, Arne ; Meng, Xianyi ; Rauber, Simon ; Steinkasserer, Alexander ; Fromm, Martin ; Schett, Georg ; Bozec, Aline
Publisher:England: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2024-12, Vol.83 (12), p.1691-1706
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Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis
Author / Creator:Kieler, Markus ; Prammer, Leona Sophia ; Heller, Gerwin ; Hofmann, Melanie ; Sperger, Simon ; Hanetseder, Dominik ; Niederreiter, Birgit ; Komljenovic, Andrea ; Klavins, Kristaps ; Köcher, Thomas ; Brunner, Julia Stefanie ; Stanic, Irena ; Oberbichler, Laura ; Korosec, Ana ; Vogel, Andrea ; Kerndl, Martina ; Hromadová, Dominika ; Musiejovsky, Laszlo ; Hajto, Alexander ; Dobrijevic, Anja ; Piwonka, Tina ; Haschemi, Arvand ; Miller, Anne ; Georgel, Philippe ; Marolt Presen, Darja ; Grillari, Johannes ; Hayer, Silvia ; Auger, Jean-Philippe ; Krönke, Gerhard ; Sharif, Omar ; Aletaha, Daniel ; Schabbauer, Gernot ; Blüml, Stephan
Publisher:England: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2024-11, Vol.83 (11), p.1465-1479
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Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats
Author / Creator:Ghotbeddin, Zohreh ; Jahromi, Mohammad Abiri ; Shahriari, Ali ; Peysokhan, Mohsen ; Dezfouli, Anahita Memar
Publisher:United States: Public Library of Science
Journal title:PloS one, 2025-03, Vol.20 (3), p.e0318430
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The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain
Author / Creator:Ohm, Melanie ; Hosseini, Shirin ; Lonnemann, Niklas ; He, Wei ; More, Tushar ; Goldmann, Oliver ; Medina, Eva ; Hiller, Karsten ; Korte, Martin
Publisher:England: BioMed Central Ltd
Journal title:Journal of neuroinflammation, 2024-08, Vol.21 (1), p.207-30, Article 207
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Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways
Author / Creator:Kurmasheva, Naziia ; Said, Aida ; Wong, Boaz ; Kinderman, Priscilla ; Han, Xiaoying ; Rahimic, Anna H. F. ; Kress, Alena ; Carter-Timofte, Madalina E. ; Holm, Emilia ; van der Horst, Demi ; Kollmann, Christoph F. ; Liu, Zhenlong ; Wang, Chen ; Hoang, Huy-Dung ; Kovalenko, Elina ; Chrysopoulou, Maria ; Twayana, Krishna Sundar ; Ottosen, Rasmus N. ; Svenningsen, Esben B. ; Begnini, Fabio ; Kiib, Anders E. ; Kromm, Florian E. H. ; Weiss, Hauke J. ; Di Carlo, Daniele ; Muscolini, Michela ; Higgins, Maureen ; van der Heijden, Mirte ; Arulanandam, Rozanne ; Bardoul, Angelina ; Tong, Tong ; Ozsvar, Attila ; Hou, Wen-Hsien ; Schack, Vivien R. ; Holm, Christian K. ; Zheng, Yunan ; Ruzek, Melanie ; Kalucka, Joanna ; de la Vega, Laureano ; Elgaher, Walid A. M. ; Korshoej, Anders R. ; Lin, Rongtuan ; Hiscott, John ; Poulsen, Thomas B. ; O’Neill, Luke A. ; Roy, Dominic G. ; Rinschen, Markus M. ; van Montfoort, Nadine ; Diallo, Jean-Simon ; Farin, Henner F. ; Alain, Tommy ; Olagnier, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-05, Vol.15 (1), p.4096-28, Article 4096
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SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

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Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses

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4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

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Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

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The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response

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Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming

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Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

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Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation

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Itaconate promotes hepatocellular carcinoma progression by epigenetic induction of CD8+ T-cell exhaustion

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Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection

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Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

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Itaconic acid exerts anti-inflammatory and antibacterial effects via promoting pentose phosphate pathway to produce ROS

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Itaconate: A Potent Macrophage Immunomodulator: Itaconate: A Potent Macrophage Immunomodulator

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Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis

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4-Octyl itaconate alleviates endothelial cell inflammation and barrier dysfunction in LPS-induced sepsis via modulating TLR4/MAPK/NF-κB signaling : 4-Octyl itaconate alleviates endothelial dysfunction

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Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis

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Itaconate is a metabolic regulator of bone formation in homeostasis and arthritis

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Neonatal febrile seizures: Dimethyl itaconate’s role in behavioral recovery and glutathione enzyme modulation in adult rats

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The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain

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Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways

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