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ArticlesPeer ReviewedFull Text
Apabetalone in chronic kidney disease
Author / Creator:Allison, Susan
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Nephrology, 2021-07, Vol.17 (7), p.437-437
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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism
Author / Creator:Tsujikawa, Laura M ; Fu, Li ; Das, Shovon ; Halliday, Christopher ; Rakai, Brooke D ; Stotz, Stephanie C ; Sarsons, Christopher D ; Gilham, Dean ; Daze, Emily ; Wasiak, Sylwia ; Studer, Deborah ; Rinker, Kristina D ; Sweeney, Michael ; Johansson, Jan O ; Wong, Norman C W ; Kulikowski, Ewelina
Publisher:Germany: BioMed Central Ltd
Journal title:Clinical epigenetics, 2019-07, Vol.11 (1), p.102, Article 102
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ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin‐1‐dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone
Author / Creator:Aguirre‐Portolés, Cristina ; Feliu, Jaime ; Reglero, Guillermo ; Ramírez de Molina, Ana
Publisher:United States: John Wiley & Sons, Inc
Journal title:Molecular oncology, 2018-10, Vol.12 (10), p.1735-1752
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Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study
Author / Creator:Nicholls, Stephen J ; Schwartz, Gregory G ; Buhr, Kevin A ; Ginsberg, Henry N ; Johansson, Jan O ; Kalantar-Zadeh, Kamyar ; Kulikowski, Ewelina ; Toth, Peter P ; Wong, Norman ; Sweeney, Michael ; Ray, Kausik K
Publisher:England: BioMed Central
Journal title:Cardiovascular diabetology, 2021-01, Vol.20 (1), p.13-13, Article 13
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Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE...
Author / Creator:Ray, Kausik K. ; Nicholls, Stephen J. ; Ginsberg, Henry D ; Johansson, Jan O. ; Kalantar-Zadeh, Kamyar ; Kulikowski, Ewelina ; Toth, Peter P. ; Wong, Norman ; Cummings, Jeffrey L. ; Sweeney, Michael ; Schwartz, Gregory G.
Publisher:United States: Elsevier Inc
Journal title:The American heart journal, 2019-11, Vol.217, p.72-83
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BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes
Author / Creator:Wasiak, Sylwia ; Dzobo, Kim E ; Rakai, Brooke D ; Kaiser, Yannick ; Versloot, Miranda ; Bahjat, Mahnoush ; Stotz, Stephanie C ; Fu, Li ; Sweeney, Michael ; Johansson, Jan O ; Wong, Norman C W ; Stroes, Erik S G ; Kroon, Jeffrey ; Kulikowski, Ewelina
Publisher:Germany: BioMed Central Ltd
Journal title:Clinical epigenetics, 2020-11, Vol.12 (1), p.166-166, Article 166
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Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression
Author / Creator:Shahid, Sidra ; Pantakani, Marlena ; Binder, Lutz ; Fischer, Andreas ; Pantakani, Krishna ; Asif, Abdul R
Publisher:Basel: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-11, Vol.27 (21), p.7453
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The BET bromodomain inhibitor apabetalone induces apoptosis of latent HIV-1 reservoir cells following viral reactivation
Author / Creator:Zhang, Xuan-xuan ; Lin, Jian ; Liang, Tai-zhen ; Duan, Heng ; Tan, Xing-hua ; Xi, Bao-min ; Li, Lin ; Liu, Shu-wen
Publisher:London: Nature Publishing Group UK
Journal title:Acta pharmacologica Sinica, 2019-01, Vol.40 (1), p.98-110
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Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease
Author / Creator:Nicholls, Stephen J. ; Ray, Kausik K. ; Johansson, Jan O. ; Gordon, Alan ; Sweeney, Michael ; Halliday, Chris ; Kulikowski, Ewelina ; Wong, Norman ; Kim, Susan W. ; Schwartz, Gregory G.
Publisher:Cham: Springer International Publishing
Journal title:American journal of cardiovascular drugs : drugs, devices, and other interventions, 2018-04, Vol.18 (2), p.109-115
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Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease
Author / Creator:Kulikowski, Ewelina ; Halliday, Christopher ; Johansson, Jan ; Sweeney, Mike ; Lebioda, Kenneth ; Wong, Norman ; Haarhaus, Mathias ; Brandenburg, Vincent ; Beddhu, Srinivasan ; Tonelli, Marcello ; Zoccali, Carmine ; Kalantar-Zadeh, Kamyar
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Kidney & blood pressure research, 2018-01, Vol.43 (2), p.449-457
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The Effect of Bromodomain and Extra-Terminal Inhibitor Apabetalone on Attenuated Coronary Atherosclerotic Plaque: Insights from the ASSURE Trial
Author / Creator:Shishikura, Daisuke ; Kataoka, Yu ; Honda, Satoshi ; Takata, Kohei ; Kim, Susan W. ; Andrews, Jordan ; Psaltis, Peter J. ; Sweeney, Michael ; Kulikowski, Ewelina ; Johansson, Jan ; Wong, Norman C. W. ; Nicholls, Stephen J.
Publisher:Cham: Springer International Publishing
Journal title:American journal of cardiovascular drugs : drugs, devices, and other interventions, 2019-02, Vol.19 (1), p.49-57
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Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment
Author / Creator:Gilham, Dean ; Wasiak, Sylwia ; Rakai, Brooke D ; Fu, Li ; Tsujikawa, Laura M ; Sarsons, Christopher D ; Carestia, Agostina ; Lebioda, Kenneth ; Johansson, Jan O ; Sweeney, Michael ; Kalantar-Zadeh, Kamyar ; Kulikowski, Ewelina
Publisher:Switzerland: MDPI AG
Journal title:Biomedicines, 2023-06, Vol.11 (6), p.1663
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Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro
Author / Creator:Gilham, Dean ; Smith, Audrey L ; Fu, Li ; Moore, Dalia Y ; Muralidharan, Abenaya ; Reid, St Patrick M ; Stotz, Stephanie C ; Johansson, Jan O ; Sweeney, Michael ; Wong, Norman C W ; Kulikowski, Ewelina ; El-Gamal, Dalia
Publisher:Switzerland: MDPI AG
Journal title:Biomedicines, 2021-04, Vol.9 (4), p.437
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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease
Author / Creator:Sweeney, Michael ; Johansson, Jan O. ; Wong, Norman C. W. ; Kulikowski, Ewelina ; Fu, Li ; Rakai, Brooke D. ; Stotz, Stephanie C. ; Halliday, Christopher ; Tsujikawa, Laura M. ; Daze, Emily ; Gilham, Dean ; Wasiak, Sylwia ; Jahagirdar, Ravi
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Cardiovascular therapeutics, 2020, Vol.2020 (2020), p.1-12
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Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells
Author / Creator:Sarsons, Christopher D ; Gilham, Dean ; Tsujikawa, Laura M ; Wasiak, Sylwia ; Fu, Li ; Rakai, Brooke D ; Stotz, Stephanie C ; Carestia, Agostina ; Sweeney, Michael ; Kulikowski, Ewelina
Publisher:Basel: MDPI AG
Journal title:Biomedicines, 2023-09, Vol.11 (10), p.2683
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The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation
Author / Creator:Wasiak, Sylwia ; Fu, Li ; Daze, Emily ; Gilham, Dean ; Rakai, Brooke D. ; Stotz, Stephanie C. ; Tsujikawa, Laura M. ; Sarsons, Chris D. ; Studer, Deborah ; Rinker, Kristina D. ; Jahagirdar, Ravi ; Wong, Norman C. W. ; Sweeney, Michael ; Johansson, Jan O. ; Kulikowski, Ewelina
Publisher:Germany: De Gruyter
Journal title:Translational neuroscience, 2023-01, Vol.14 (1), p.20220332-20220332
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BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis
Author / Creator:CHEN, MEIHUA ; WANG, HUIHUI ; CHEN, XIAOFENG ; CHEN, YAN ; BIAN, TIANYING
Journal title:Biocell, 2022, Vol.46 (10), p.2281-2289
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Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy
Author / Creator:Fu, Li ; Wasiak, Sylwia ; Tsujikawa, Laura M. ; Rakai, Brooke D. ; Stotz, Stephanie C. ; Wong, Norman C. W. ; Johansson, Jan O. ; Sweeney, Michael ; Mohan, Connie M. ; Khan, Aneal ; Kulikowski, Ewelina
Publisher:United States: John Wiley & Sons, Inc
Journal title:Pharmacology research & perspectives, 2022-06, Vol.10 (3), p.e00949-n/a
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Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease
Author / Creator:Martinez-Moreno, Julio M ; Fontecha-Barriuso, Miguel ; Martin-Sanchez, Diego ; Guerrero-Mauvecin, Juan ; Goma-Garces, Elena ; Fernandez-Fernandez, Beatriz ; Carriazo, Sol ; Sanchez-Niño, Maria D ; Ramos, Adrian M ; Ruiz-Ortega, Marta ; Ortiz, Alberto ; Sanz, Ana B
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-06, Vol.21 (11), p.4113
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Studies from Resverlogix Corporation Yield New Data on Biomedicine (Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells)
Publisher:NewsRX LLC
Journal title:Obesity, fitness, & wellness week, 2023-11, p.899
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Apabetalone in chronic kidney disease

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Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism

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ABCA1 overexpression worsens colorectal cancer prognosis by facilitating tumour growth and caveolin‐1‐dependent invasiveness, and these effects can be ameliorated using the BET inhibitor apabetalone

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Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study

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Effect of selective BET protein inhibitor apabetalone on cardiovascular outcomes in patients with acute coronary syndrome and diabetes: Rationale, design, and baseline characteristics of the BETonMACE...

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BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes

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Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

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The BET bromodomain inhibitor apabetalone induces apoptosis of latent HIV-1 reservoir cells following viral reactivation

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Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease

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Apabetalone Mediated Epigenetic Modulation is Associated with Favorable Kidney Function and Alkaline Phosphatase Profile in Patients with Chronic Kidney Disease

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The Effect of Bromodomain and Extra-Terminal Inhibitor Apabetalone on Attenuated Coronary Atherosclerotic Plaque: Insights from the ASSURE Trial

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Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment

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Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro

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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

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Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells

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The BET inhibitor apabetalone decreases neuroendothelial proinflammatory activation in vitro and in a mouse model of systemic inflammation

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BET protein inhibitor apabetalone represses Porphyromonas gingivalis LPS-induced macrophage M1 polarization via regulating miR-130a/STAT3 axis

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Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy

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Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease

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Studies from Resverlogix Corporation Yield New Data on Biomedicine (Apabetalone, a Clinical-Stage, Selective BET Inhibitor, Opposes DUX4 Target Gene Expression in Primary Human FSHD Muscle Cells)

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