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Select record 21
ArticlesPeer ReviewedFull Text
Scaling analysis reveals the mechanism and rates of prion replication in vivo
Author / Creator:Meisl, Georg ; Kurt, Timothy ; Condado-Morales, Itzel ; Bett, Cyrus ; Sorce, Silvia ; Nuvolone, Mario ; Michaels, Thomas C. T. ; Heinzer, Daniel ; Avar, Merve ; Cohen, Samuel I. A. ; Hornemann, Simone ; Aguzzi, Adriano ; Dobson, Christopher M. ; Sigurdson, Christina J. ; Knowles, Tuomas P. J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2021-04, Vol.28 (4), p.365-372
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Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
Author / Creator:Limbocker, Ryan ; Staats, Roxine ; Chia, Sean ; Ruggeri, Francesco S ; Mannini, Benedetta ; Xu, Catherine K ; Perni, Michele ; Cascella, Roberta ; Bigi, Alessandra ; Sasser, Liam R ; Block, Natalie R ; Wright, Aidan K ; Kreiser, Ryan P ; Custy, Edward T ; Meisl, Georg ; Errico, Silvia ; Habchi, Johnny ; Flagmeier, Patrick ; Kartanas, Tadas ; Hollows, Jared E ; Nguyen, Lam T ; LeForte, Kathleen ; Barbut, Denise ; Kumita, Janet R ; Cecchi, Cristina ; Zasloff, Michael ; Knowles, Tuomas P J ; Dobson, Christopher M ; Chiti, Fabrizio ; Vendruscolo, Michele
Publisher:Switzerland: Frontiers Research Foundation
Journal title:Frontiers in neuroscience, 2021-06, Vol.15, p.680026
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α-Synuclein oligomers form by secondary nucleation
Author / Creator:Xu, Catherine K. ; Meisl, Georg ; Andrzejewska, Ewa A. ; Krainer, Georg ; Dear, Alexander J. ; Castellana-Cruz, Marta ; Turi, Soma ; Edu, Irina A. ; Vivacqua, Giorgio ; Jacquat, Raphaël P. B. ; Arter, William E. ; Spillantini, Maria Grazia ; Vendruscolo, Michele ; Linse, Sara ; Knowles, Tuomas P. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-08, Vol.15 (1), p.7083-11, Article 7083
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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity
Author / Creator:Xu, Catherine K ; Castellana-Cruz, Marta ; Chen, Serene W ; Du, Zhen ; Meisl, Georg ; Levin, Aviad ; Mannini, Benedetta ; Itzhaki, Laura S ; Knowles, Tuomas P J ; Dobson, Christopher M ; Cremades, Nunilo ; Kumita, Janet R
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2022-02, Vol.27 (4), p.1293
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Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
Author / Creator:Sang, Jason C. ; Hidari, Eric ; Meisl, Georg ; Ranasinghe, Rohan T. ; Spillantini, Maria Grazia ; Klenerman, David
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2021-05, Vol.4 (1), p.613-613, Article 613
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Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid
Author / Creator:Frankel, Rebecca ; Törnquist, Mattias ; Meisl, Georg ; Hansson, Oskar ; Andreasson, Ulf ; Zetterberg, Henrik ; Blennow, Kaj ; Frohm, Birgitta ; Cedervall, Tommy ; Knowles, Tuomas P. J. ; Leiding, Thom ; Linse, Sara
Publisher:London: Nature Publishing Group UK
Journal title:Communications biology, 2019-10, Vol.2 (1), p.365-365, Article 365
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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
Author / Creator:Taylor, Jonathan D. ; Hawthorne, William J. ; Lo, Joanne ; Dear, Alexander ; Jain, Neha ; Meisl, Georg ; Andreasen, Maria ; Fletcher, Catherine ; Koch, Marion ; Darvill, Nicholas ; Scull, Nicola ; Escalera-Maurer, Andrés ; Sefer, Lea ; Wenman, Rosemary ; Lambert, Sebastian ; Jean, Jisoo ; Xu, Yingqi ; Turner, Benjamin ; Kazarian, Sergei G. ; Chapman, Matthew R. ; Bubeck, Doryen ; de Simone, Alfonso ; Knowles, Tuomas P. J. ; Matthews, Steve J.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-04, Vol.6 (1), p.24656-24656, Article 24656
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Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Author / Creator:Limbocker, Ryan ; Chia, Sean ; Ruggeri, Francesco S. ; Perni, Michele ; Cascella, Roberta ; Heller, Gabriella T. ; Meisl, Georg ; Mannini, Benedetta ; Habchi, Johnny ; Michaels, Thomas C. T. ; Challa, Pavan K. ; Ahn, Minkoo ; Casford, Samuel T. ; Fernando, Nilumi ; Xu, Catherine K. ; Kloss, Nina D. ; Cohen, Samuel I. A. ; Kumita, Janet R. ; Cecchi, Cristina ; Zasloff, Michael ; Linse, Sara ; Knowles, Tuomas P. J. ; Chiti, Fabrizio ; Vendruscolo, Michele ; Dobson, Christopher M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.1-13, Article 225
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Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
Author / Creator:Michaels, Thomas C. T. ; Šarić, Andela ; Curk, Samo ; Bernfur, Katja ; Arosio, Paolo ; Meisl, Georg ; Dear, Alexander J. ; Cohen, Samuel I. A. ; Dobson, Christopher M. ; Vendruscolo, Michele ; Linse, Sara ; Knowles, Tuomas P. J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2020-05, Vol.12 (5), p.497-497
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Preventing peptide and protein misbehavior
Author / Creator:Arosio, Paolo ; Meisl, Georg ; Andreasen, Maria ; Knowles, Tuomas P. J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (17), p.5267-5268
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A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli
Author / Creator:Sanagavarapu, Kalyani ; Nüske, Elisabeth ; Nasir, Irem ; Meisl, Georg ; Immink, Jasper N. ; Sormanni, Pietro ; Vendruscolo, Michele ; Knowles, Tuomas P. J. ; Malmendal, Anders ; Cabaleiro-Lago, Celia ; Linse, Sara
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-03, Vol.9 (1), p.3680-3680, Article 3680
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Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers
Author / Creator:Najarzadeh, Zahra ; Mohammad-Beigi, Hossein ; Nedergaard Pedersen, Jannik ; Christiansen, Gunna ; Sønderby, Thorbjørn Vincent ; Shojaosadati, Seyed Abbas ; Morshedi, Dina ; Strømgaard, Kristian ; Meisl, Georg ; Sutherland, Duncan ; Skov Pedersen, Jan ; Otzen, Daniel E
Publisher:Switzerland: MDPI
Journal title:Biomolecules (Basel, Switzerland), 2019-10, Vol.9 (11), p.659
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ArticlesPeer ReviewedFull Text
On the role of sidechain size and charge in the aggregation of A β 42 with familial mutations
Author / Creator:Yang, Xiaoting ; Meisl, Georg ; Frohm, Birgitta ; Thulin, Eva ; Knowles, Tuomas P J ; Linse, Sara
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.E5849
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Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation
Author / Creator:Flagmeier, Patrick ; Meisl, Georg ; Vendruscolo, Michele ; Knowles, Tuomas P. J. ; Dobson, Christopher M. ; Buell, Alexander K. ; Galvagnion, Céline
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-09, Vol.113 (37), p.10328-10333
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On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations
Author / Creator:Yang, Xiaoting ; Meisl, Georg ; Frohm, Birgitta ; Thulin, Eva ; Knowles, Tuomas P. J. ; Linse, Sara
Publisher:National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (26), p.E5849-E5858
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Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide
Author / Creator:Meisl, Georg ; Yang, Xiaoting ; Frohm, Birgitta ; Knowles, Tuomas P. J. ; Linse, Sara
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-01, Vol.6 (1), p.18728, Article 18728
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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation
Author / Creator:Galvagnion, Céline ; Buell, Alexander K ; Meisl, Georg ; Michaels, Thomas C T ; Vendruscolo, Michele ; Knowles, Tuomas P J ; Dobson, Christopher M
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2015-03, Vol.11 (3), p.229-234
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Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification
Author / Creator:Gaspar, Ricardo ; Meisl, Georg ; Buell, Alexander K. ; Young, Laurence ; Kaminski, Clemens F. ; Knowles, Tuomas P. J. ; Sparr, Emma ; Linse, Sara
Publisher:New York, USA: Cambridge University Press
Journal title:Quarterly reviews of biophysics, 2017-01, Vol.50, p.e6-e6, Article e6
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Trodusquemine enhances Aβ 42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
Author / Creator:Limbocker, Ryan ; Chia, Sean ; Ruggeri, Francesco S ; Perni, Michele ; Cascella, Roberta ; Heller, Gabriella T ; Meisl, Georg ; Mannini, Benedetta ; Habchi, Johnny ; Michaels, Thomas C T ; Challa, Pavan K ; Ahn, Minkoo ; Casford, Samuel T ; Fernando, Nilumi ; Xu, Catherine K ; Kloss, Nina D ; Cohen, Samuel I A ; Kumita, Janet R ; Cecchi, Cristina ; Zasloff, Michael ; Linse, Sara ; Knowles, Tuomas P J ; Chiti, Fabrizio ; Vendruscolo, Michele ; Dobson, Christopher M
Publisher:England
Journal title:Nature communications, 2019-12, Vol.10 (1), p.225
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α-Synuclein strains target distinct brain regions and cell types
Author / Creator:Lau, Angus ; So, Raphaella W. L. ; Lau, Heather H. C. ; Sang, Jason C. ; Ruiz-Riquelme, Alejandro ; Fleck, Shelaine C. ; Stuart, Erica ; Menon, Sindhu ; Visanji, Naomi P. ; Meisl, Georg ; Faidi, Rania ; Marano, Maria M. ; Schmitt-Ulms, Cian ; Wang, Zhilan ; Fraser, Paul E. ; Tandon, Anurag ; Hyman, Bradley T. ; Wille, Holger ; Ingelsson, Martin ; Klenerman, David ; Watts, Joel C.
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2020-01, Vol.23 (1), p.21-31
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Scaling analysis reveals the mechanism and rates of prion replication in vivo

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Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers

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α-Synuclein oligomers form by secondary nucleation

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The Pathological G51D Mutation in Alpha-Synuclein Oligomers Confers Distinct Structural Attributes and Cellular Toxicity

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Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells

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Autocatalytic amplification of Alzheimer-associated Aβ42 peptide aggregation in human cerebrospinal fluid

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Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

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Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

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Author Correction: Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide

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Preventing peptide and protein misbehavior

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A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

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Plant Polyphenols Inhibit Functional Amyloid and Biofilm Formation in Pseudomonas Strains by Directing Monomers to Off-Pathway Oligomers

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On the role of sidechain size and charge in the aggregation of A β 42 with familial mutations

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Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

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On the role of sidechain size and charge in the aggregation of Aβ42 with familial mutations

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Quantitative analysis of intrinsic and extrinsic factors in the aggregation mechanism of Alzheimer-associated Aβ-peptide

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Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

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Secondary nucleation of monomers on fibril surface dominates α-synuclein aggregation and provides autocatalytic amyloid amplification

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Trodusquemine enhances Aβ 42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes

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α-Synuclein strains target distinct brain regions and cell types

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