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92 results for Apolipoprotein+E3+-+metabolism

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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids
Author / Creator:Zhao, Jing ; Fu, Yuan ; Yamazaki, Yu ; Ren, Yingxue ; Davis, Mary D. ; Liu, Chia-Chen ; Lu, Wenyan ; Wang, Xue ; Chen, Kai ; Cherukuri, Yesesri ; Jia, Lin ; Martens, Yuka A. ; Job, Lucy ; Shue, Francis ; Nguyen, Thanh Thanh ; Younkin, Steven G. ; Graff-Radford, Neill R. ; Wszolek, Zbigniew K. ; Brafman, David A. ; Asmann, Yan W. ; Ertekin-Taner, Nilüfer ; Kanekiyo, Takahisa ; Bu, Guojun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-11, Vol.11 (1), p.5540-5540, Article 5540
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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector
Author / Creator:Wang, Chengzhong ; Najm, Ramsey ; Xu, Qin ; Jeong, Dah-eun ; Walker, David ; Balestra, Maureen E. ; Yoon, Seo Yeon ; Yuan, Heidi ; Li, Gang ; Miller, Zachary A. ; Miller, Bruce L. ; Malloy, Mary J. ; Huang, Yadong
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2018-05, Vol.24 (5), p.647-657
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Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function
Author / Creator:Liu, Chia-Chen ; Zhao, Jing ; Fu, Yuan ; Inoue, Yasuteru ; Ren, Yingxue ; Chen, Yuanxin ; Doss, Sydney V. ; Shue, Francis ; Jeevaratnam, Suren ; Bastea, Ligia ; Wang, Na ; Martens, Yuka A. ; Qiao, Wenhui ; Wang, Minghui ; Zhao, Na ; Jia, Lin ; Yamazaki, Yu ; Yamazaki, Akari ; Rosenberg, Cassandra L. ; Wang, Zhen ; Kong, Dehui ; Li, Zonghua ; Kuchenbecker, Lindsey A. ; Trottier, Zachary A. ; Felton, Lindsey ; Rogers, Justin ; Quicksall, Zachary S. ; Linares, Cynthia ; Knight, Joshua ; Chen, Yixing ; Kurti, Aishe ; Kanekiyo, Takahisa ; Fryer, John D. ; Asmann, Yan W. ; Storz, Peter ; Wang, Xusheng ; Peng, Junmin ; Zhang, Bin ; Kim, Betty Y. S. ; Bu, Guojun
Publisher:New York: Nature Publishing Group US
Journal title:Nature neuroscience, 2022-08, Vol.25 (8), p.1020-1033
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Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease
Author / Creator:Liu, Chia-Chen ; Wang, Na ; Chen, Yuanxin ; Inoue, Yasuteru ; Shue, Francis ; Ren, Yingxue ; Wang, Minghui ; Qiao, Wenhui ; Ikezu, Tadafumi C. ; Li, Zonghua ; Zhao, Jing ; Martens, Yuka ; Doss, Sydney V. ; Rosenberg, Cassandra L. ; Jeevaratnam, Suren ; Jia, Lin ; Raulin, Ana-Caroline ; Qi, Fangfang ; Zhu, Yiyang ; Alnobani, Alla ; Knight, Joshua ; Chen, Yixing ; Linares, Cynthia ; Kurti, Aishe ; Fryer, John D. ; Zhang, Bin ; Wu, Long-Jun ; Kim, Betty Y. S. ; Bu, Guojun
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2023-11, Vol.24 (11), p.1854-1866
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Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes
Author / Creator:Blanchard, Joel W. ; Bula, Michael ; Davila-Velderrain, Jose ; Akay, Leyla Anne ; Zhu, Lena ; Frank, Alexander ; Victor, Matheus B. ; Bonner, Julia Maeve ; Mathys, Hansruedi ; Lin, Yuan-Ta ; Ko, Tak ; Bennett, David A. ; Cam, Hugh P. ; Kellis, Manolis ; Tsai, Li-Huei
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-06, Vol.26 (6), p.952-963
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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
Author / Creator:Liao, Fan ; Li, Aimin ; Xiong, Monica ; Bien-Ly, Nga ; Jiang, Hong ; Zhang, Yin ; Finn, Mary Beth ; Hoyle, Rosa ; Keyser, Jennifer ; Lefton, Katheryn B. ; Robinson, Grace O. ; Serrano, Javier Remolina ; Silverman, Adam P. ; Guo, Jing L. ; Getz, Jennifer ; Henne, Kirk ; Leyns, Cheryl E.G. ; Gallardo, Gilbert ; Ulrich, Jason D. ; Sullivan, Patrick M. ; Lerner, Eli Paul ; Hudry, Eloise ; Sweeney, Zachary K. ; Dennis, Mark S. ; Hyman, Bradley T. ; Watts, Ryan J. ; Holtzman, David M.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-05, Vol.128 (5), p.2144-2155
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Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia
Author / Creator:Sepulveda-Falla, Diego ; Sanchez, Justin S. ; Almeida, Maria Camila ; Boassa, Daniela ; Acosta-Uribe, Juliana ; Vila-Castelar, Clara ; Ramirez-Gomez, Liliana ; Baena, Ana ; Aguillon, David ; Villalba-Moreno, Nelson David ; Littau, Jessica Lisa ; Villegas, Andres ; Beach, Thomas G. ; White, Charles L. ; Ellisman, Mark ; Krasemann, Susanne ; Glatzel, Markus ; Johnson, Keith A. ; Sperling, Reisa A. ; Reiman, Eric M. ; Arboleda-Velasquez, Joseph F. ; Kosik, Kenneth S. ; Lopera, Francisco ; Quiroz, Yakeel T.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Acta neuropathologica, 2022-09, Vol.144 (3), p.589-601
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Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis
Author / Creator:Huang, Jia-Lin ; Jiang, Gan ; Song, Qing-Xiang ; Gu, Xiao ; Hu, Meng ; Wang, Xiao-Lin ; Song, Hua-Hua ; Chen, Le-Pei ; Lin, Ying-Ying ; Jiang, Di ; Chen, Jun ; Feng, Jun-Feng ; Qiu, Yong-Ming ; Jiang, Ji-Yao ; Jiang, Xin-Guo ; Chen, Hong-Zhuan ; Gao, Xiao-Ling
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15144-15144, Article 15144
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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
Author / Creator:Fitz, Nicholas F. ; Nam, Kyong Nyon ; Wolfe, Cody M. ; Letronne, Florent ; Playso, Brittany E. ; Iordanova, Bistra E. ; Kozai, Takashi D. Y. ; Biedrzycki, Richard J. ; Kagan, Valerian E. ; Tyurina, Yulia Y. ; Han, Xianlin ; Lefterov, Iliya ; Koldamova, Radosveta
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3416-18, Article 3416
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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Author / Creator:Bell, Robert D. ; Winkler, Ethan A. ; Singh, Itender ; Sagare, Abhay P. ; Deane, Rashid ; Wu, Zhenhua ; Holtzman, David M. ; Betsholtz, Christer ; Armulik, Annika ; Sallstrom, Jan ; Berk, Bradford C. ; Zlokovic, Berislav V.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2012-05, Vol.485 (7399), p.512-516
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Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Author / Creator:Mahan, Thomas E. ; Wang, Chao ; Bao, Xin ; Choudhury, Ankit ; Ulrich, Jason D. ; Holtzman, David M.
Publisher:England: BioMed Central
Journal title:Molecular neurodegeneration, 2022-02, Vol.17 (1), p.13-13, Article 13
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Altered mitochondrial dynamics and function in APOE4-expressing astrocytes
Author / Creator:Schmukler, Eran ; Solomon, Shira ; Simonovitch, Shira ; Goldshmit, Yona ; Wolfson, Eya ; Michaelson, Daniel Morris ; Pinkas-Kramarski, Ronit
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-07, Vol.11 (7), p.578, Article 578
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Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury
Author / Creator:Main, Bevan S. ; Villapol, Sonia ; Sloley, Stephanie S. ; Barton, David J. ; Parsadanian, Maia ; Agbaegbu, Chinyere ; Stefos, Kathryn ; McCann, Mondona S. ; Washington, Patricia M. ; Rodriguez, Olga C. ; Burns, Mark P.
Publisher:England: BioMed Central Ltd
Journal title:Molecular neurodegeneration, 2018-04, Vol.13 (1), p.17-17, Article 17
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apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
Author / Creator:Deane, Rashid ; Sagare, Abhay ; Hamm, Katie ; Parisi, Margaret ; Lane, Steven ; Finn, Mary Beth ; Holtzman, David M. ; Zlokovic, Berislav V.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2008-12, Vol.118 (12), p.4002-4013
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A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions
Author / Creator:Frieden, Carl ; Wang, Hanliu ; Ho, Chris M. W.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2017-06, Vol.114 (24), p.6292-6297
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Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions
Author / Creator:Chen, Jianglei ; Li, Qianqian ; Wang, Jianjun
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-09, Vol.108 (36), p.14813-14818
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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice
Author / Creator:Miranda, André Miguel ; Ashok, Archana ; Chan, Robin Barry ; Zhou, Bowen ; Xu, Yimeng ; McIntire, Laura Beth ; Area-Gomez, Estela ; Di Paolo, Gilbert ; Duff, Karen E. ; Oliveira, Tiago Gil ; Nuriel, Tal
Publisher:London: Nature Publishing Group UK
Journal title:Translational psychiatry, 2022-03, Vol.12 (1), p.129-10, Article 129
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A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
Author / Creator:Wasielewska, Joanna M. ; Chaves, Juliana C. S. ; Johnston, Rebecca L. ; Milton, Laura A. ; Hernández, Damián ; Chen, Liyu ; Song, Jae ; Lee, Wendy ; Leinenga, Gerhard ; Nisbet, Rebecca M. ; Pébay, Alice ; Götz, Jürgen ; White, Anthony R. ; Oikari, Lotta E.
Publisher:Australia: Ivyspring International Publisher Pty Ltd
Journal title:Theranostics, 2022-01, Vol.12 (16), p.6826-6847
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Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection
Author / Creator:Henao‐Restrepo, Julián ; López‐Murillo, Carolina ; Valderrama‐Carmona, Pablo ; Orozco‐Santa, Natalia ; Gomez, Johana ; Gutiérrez‐Vargas, Johanna ; Moraga, Renato ; Toledo, Jorge ; Littau, Jessica Lisa ; Härtel, Steffen ; Arboleda‐Velásquez, Joseph F. ; Sepulveda‐Falla, Diego ; Lopera, Francisco ; Cardona‐Gómez, Gloria Patricia ; Villegas, Andrés ; Posada‐Duque, Rafael
Publisher:Switzerland: John Wiley & Sons, Inc
Journal title:Brain pathology (Zurich, Switzerland), 2023-03, Vol.33 (2), p.e13119-n/a
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Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus
Author / Creator:Boutros, Sydney Weber ; Zimmerman, Benjamin ; Nagy, Sydney C. ; Unni, Vivek K. ; Raber, Jacob
Publisher:London: Nature Publishing Group UK
Journal title:Molecular psychiatry, 2023-08, Vol.28 (8), p.3343-3354
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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

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Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

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Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

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Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

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Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

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Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia

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Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

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Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease

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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

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Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

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Altered mitochondrial dynamics and function in APOE4-expressing astrocytes

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Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury

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apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

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A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions

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Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

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Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice

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A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies

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Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection

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Age, sex, and apolipoprotein E isoform alter contextual fear learning, neuronal activation, and baseline DNA damage in the hippocampus

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