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342 results for Macrolides+-+chemistry

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ArticlesPeer ReviewedFull Text
Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship
Author / Creator:Song, Xiaoyuan ; Yuan, Ganjun ; Li, Peibo ; Cao, Sheng
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2019-10, Vol.24 (21), p.3913
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A platform for the discovery of new macrolide antibiotics
Author / Creator:Seiple, Ian B. ; Zhang, Ziyang ; Jakubec, Pavol ; Langlois-Mercier, Audrey ; Wright, Peter M. ; Hog, Daniel T. ; Yabu, Kazuo ; Allu, Senkara Rao ; Fukuzaki, Takehiro ; Carlsen, Peter N. ; Kitamura, Yoshiaki ; Zhou, Xiang ; Condakes, Matthew L. ; Szczypiński, Filip T. ; Green, William D. ; Myers, Andrew G.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-05, Vol.533 (7603), p.338-345
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Algorithm-aided engineering of aliphatic halogenase WelO5 for the asymmetric late-stage functionalization of soraphens
Author / Creator:Büchler, Johannes ; Malca, Sumire Honda ; Patsch, David ; Voss, Moritz ; Turner, Nicholas J. ; Bornscheuer, Uwe T. ; Allemann, Oliver ; Le Chapelain, Camille ; Lumbroso, Alexandre ; Loiseleur, Olivier ; Buller, Rebecca
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-01, Vol.13 (1), p.371-371, Article 371
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A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation
Author / Creator:Chen, Lu ; Quan, Haitian ; Xu, Zhongliang ; Wang, Hao ; Xia, Yuanzhi ; Lou, Liguang ; Yang, Weibo
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2151-2151, Article 2151
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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms
Author / Creator:Ueoka, Reiko ; Uria, Agustinus R ; Reiter, Silke ; Mori, Tetsushi ; Karbaum, Petra ; Peters, Eike E ; Helfrich, Eric J N ; Morinaka, Brandon I ; Gugger, Muriel ; Takeyama, Haruko ; Matsunaga, Shigeki ; Piel, Jörn
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2015-09, Vol.11 (9), p.705-712
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Computational planning of the synthesis of complex natural products
Author / Creator:Mikulak-Klucznik, Barbara ; Gołębiowska, Patrycja ; Bayly, Alison A. ; Popik, Oskar ; Klucznik, Tomasz ; Szymkuć, Sara ; Gajewska, Ewa P. ; Dittwald, Piotr ; Staszewska-Krajewska, Olga ; Beker, Wiktor ; Badowski, Tomasz ; Scheidt, Karl A. ; Molga, Karol ; Mlynarski, Jacek ; Mrksich, Milan ; Grzybowski, Bartosz A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-12, Vol.588 (7836), p.83-88
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De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
Author / Creator:Berod, Luciana ; Friedrich, Christin ; Nandan, Amrita ; Freitag, Jenny ; Hagemann, Stefanie ; Harmrolfs, Kirsten ; Sandouk, Aline ; Hesse, Christina ; Castro, Carla N ; Bähre, Heike ; Tschirner, Sarah K ; Gorinski, Nataliya ; Gohmert, Melanie ; Mayer, Christian T ; Huehn, Jochen ; Ponimaskin, Evgeni ; Abraham, Wolf-Rainer ; Müller, Rolf ; Lochner, Matthias ; Sparwasser, Tim
Publisher:London: Nature Publishing Group UK
Journal title:Nature medicine, 2014-11, Vol.20 (11), p.1327-1333
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Molecular basis of V-ATPase inhibition by bafilomycin A1
Author / Creator:Wang, Rong ; Wang, Jin ; Hassan, Abdirahman ; Lee, Chia-Hsueh ; Xie, Xiao-Song ; Li, Xiaochun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1782-8, Article 1782
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The Performance of Several Docking Programs at Reproducing Protein–Macrolide-Like Crystal Structures
Author / Creator:Castro-Alvarez, Alejandro ; Costa, Anna ; Vilarrasa, Jaume
Publisher:Switzerland: MDPI AG
Journal title:Molecules (Basel, Switzerland), 2017-01, Vol.22 (1), p.136-136
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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents
Author / Creator:Prota, Andrea E. ; Bargsten, Katja ; Zurwerra, Didier ; Field, Jessica J. ; Díaz, José Fernando ; Altmann, Karl-Heinz ; Steinmetz, Michel O.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6119), p.587-590
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ArticlesPeer ReviewedFull Text
new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
Author / Creator:Prota, Andrea E. ; Bargsten, Katja ; Diaz, J. Fernando ; Marsh, May ; Cuevas, Carmen ; Liniger, Marc ; Neuhaus, Christian ; Andreu, Jose M. ; Altmann, Karl-Heinz ; Steinmetz, Michel O.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (38), p.13817-13821
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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts
Author / Creator:Van Arnam, Ethan B. ; Ruzzini, Antonio C. ; Sit, Clarissa S. ; Horn, Heidi ; Pinto-Tomás, Adrián A. ; Currie, Cameron R. ; Clardy, Jon
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (46), p.12940-12945
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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics
Author / Creator:Beckert, Bertrand ; Leroy, Elodie C. ; Sothiselvam, Shanmugapriya ; Bock, Lars V. ; Svetlov, Maxim S. ; Graf, Michael ; Arenz, Stefan ; Abdelshahid, Maha ; Seip, Britta ; Grubmüller, Helmut ; Mankin, Alexander S. ; Innis, C. Axel ; Vázquez-Laslop, Nora ; Wilson, Daniel N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-07, Vol.12 (1), p.4466-15, Article 4466
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Rapamycin-inspired macrocycles with new target specificity
Author / Creator:Guo, Zufeng ; Hong, Sam Y. ; Wang, Jingxin ; Rehan, Shahid ; Liu, Wukun ; Peng, Hanjing ; Das, Manisha ; Li, Wei ; Bhat, Shridhar ; Peiffer, Brandon ; Ullman, Brett R. ; Tse, Chung-Ming ; Tarmakova, Zlatina ; Schiene-Fischer, Cordelia ; Fischer, Gunter ; Coe, Imogen ; Paavilainen, Ville O. ; Sun, Zhaoli ; Liu, Jun O.
Publisher:London: Nature Publishing Group UK
Journal title:Nature chemistry, 2019-03, Vol.11 (3), p.254-263
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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Author / Creator:Shigdel, Uddhav K. ; Lee, Seung-Joo ; Sowa, Mathew E. ; Bowman, Brian R. ; Robison, Keith ; Zhou, Minyun ; Pua, Khian Hong ; Stiles, Dylan T. ; Blodgett, Joshua A. V. ; Udwary, Daniel W. ; Rajczewski, Andrew T. ; Mann, Alan S. ; Mostafavi, Siavash ; Hardy, Tara ; Arya, Sukrat ; Weng, Zhigang ; Stewart, Michelle ; Kenyon, Kyle ; Morgenstern, Jay P. ; Pan, Ende ; Gray, Daniel C. ; Pollock, Roy M. ; Fry, Andrew M. ; Klausner, Richard D. ; Townson, Sharon A. ; Verdine, Gregory L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (29), p.17195-17203
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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex
Author / Creator:Teng, Teng ; Tsai, Jennifer HC ; Puyang, Xiaoling ; Seiler, Michael ; Peng, Shouyong ; Prajapati, Sudeep ; Aird, Daniel ; Buonamici, Silvia ; Caleb, Benjamin ; Chan, Betty ; Corson, Laura ; Feala, Jacob ; Fekkes, Peter ; Gerard, Baudouin ; Karr, Craig ; Korpal, Manav ; Liu, Xiang ; T. Lowe, Jason ; Mizui, Yoshiharu ; Palacino, James ; Park, Eunice ; Smith, Peter G. ; Subramanian, Vanitha ; Wu, Zhenhua Jeremy ; Zou, Jian ; Yu, Lihua ; Chicas, Agustin ; Warmuth, Markus ; Larsen, Nicholas ; Zhu, Ping
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15522-15522, Article 15522
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occurrence and fate of tetracyclines in two pharmaceutical wastewater treatment plants of Northern China
Author / Creator:Hou, Jie ; Wang, Chong ; Mao, Daqing ; Luo, Yi
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Environmental science and pollution research international, 2016-01, Vol.23 (2), p.1722-1731
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Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A
Author / Creator:Kim, Hak Joong ; Ruszczycky, Mark W. ; Choi, Sei-hyun ; Liu, Yung-nan ; Liu, Hung-wen
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-05, Vol.473 (7345), p.109-112
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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
Author / Creator:Laureti, Luisa ; Song, Lijiang ; Huang, Sheng ; Corre, Christophe ; Leblond, Pierre ; Challis, Gregory L ; Aigle, Bertrand
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (15), p.6258-6263
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Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis
Author / Creator:Miyanaga, Akimasa ; Iwasawa, Shohei ; Shinohara, Yuji ; Kudo, Fumitaka ; Eguchi, Tadashi
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1802-1807
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Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship

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A platform for the discovery of new macrolide antibiotics

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Algorithm-aided engineering of aliphatic halogenase WelO5 for the asymmetric late-stage functionalization of soraphens

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A modular biomimetic strategy for the synthesis of macrolide P-glycoprotein inhibitors via Rh-catalyzed C-H activation

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Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

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Computational planning of the synthesis of complex natural products

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De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

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Molecular basis of V-ATPase inhibition by bafilomycin A1

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The Performance of Several Docking Programs at Reproducing Protein–Macrolide-Like Crystal Structures

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Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

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new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

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Selvamicin, an atypical antifungal polyene from two alternative genomic contexts

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Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics

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Rapamycin-inspired macrocycles with new target specificity

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Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface

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Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A–SF3b complex

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occurrence and fate of tetracyclines in two pharmaceutical wastewater treatment plants of Northern China

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Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

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Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis

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