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200 results for Nucleotides,+Cyclic+-+metabolism

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Select record 21
ArticlesPeer ReviewedFull Text
STING directly activates autophagy to tune the innate immune response
Author / Creator:Liu, Dong ; Wu, Hao ; Wang, Chenguang ; Li, Yanjun ; Tian, Huabin ; Siraj, Sami ; Sehgal, Sheikh Arslan ; Wang, Xiaohui ; Wang, Jun ; Shang, Yingli ; Jiang, Zhengfan ; Liu, Lei ; Chen, Quan
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2019-09, Vol.26 (9), p.1735-1749
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Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
Author / Creator:Xie, Wei ; Lama, Lodoe ; Adura, Carolina ; Tomita, Daisuke ; Glickman, J. Fraser ; Tuschl, Thomas ; Patel, Dinshaw J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-06, Vol.116 (24), p.11946-11955
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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1
Author / Creator:Zhao, Baoyu ; Du, Fenglei ; Xu, Pengbiao ; Shu, Chang ; Sankaran, Banumathi ; Bell, Samantha L. ; Liu, Mengmeng ; Lei, Yuanjiu ; Gao, Xinsheng ; Fu, Xiaofeng ; Zhu, Fanxiu ; Liu, Yang ; Laganowsky, Arthur ; Zheng, Xueyun ; Ji, Jun-Yuan ; West, A. Phillip ; Watson, Robert O. ; Li, Pingwei
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-05, Vol.569 (7758), p.718-722
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Activation of STING by targeting a pocket in the transmembrane domain
Author / Creator:Lu, Defen ; Shang, Guijun ; Li, Jie ; Lu, Yong ; Bai, Xiao-chen ; Zhang, Xuewu
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-04, Vol.604 (7906), p.557-562
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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer
Author / Creator:Chen, Qing ; Boire, Adrienne ; Jin, Xin ; Valiente, Manuel ; Er, Ekrem Emrah ; Lopez-Soto, Alejandro ; S. Jacob, Leni ; Patwa, Ruzeen ; Shah, Hardik ; Xu, Ke ; Cross, Justin R. ; Massagué, Joan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-05, Vol.533 (7604), p.493-498
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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
Author / Creator:Chu, Ting-Ting ; Tu, Xintao ; Yang, Kun ; Wu, Jianjun ; Repa, Joyce J. ; Yan, Nan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-08, Vol.596 (7873), p.570-575
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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Author / Creator:Wu, Jiaxi ; Sun, Lijun ; Chen, Xiang ; Du, Fenghe ; Shi, Heping ; Chen, Chuo ; Chen, Zhijian J.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6121), p.826-830
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Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells
Author / Creator:Flynn, Patrick J. ; Koch, Peter D. ; Mitchison, Timothy J.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-11, Vol.118 (48), p.1-8
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IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
Author / Creator:Almine, Jessica F. ; O’Hare, Craig A. J. ; Dunphy, Gillian ; Haga, Ismar R. ; Naik, Rangeetha J. ; Atrih, Abdelmadjid ; Connolly, Dympna J. ; Taylor, Jordan ; Kelsall, Ian R. ; Bowie, Andrew G. ; Beard, Philippa M. ; Unterholzner, Leonie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-02, Vol.8 (1), p.14392-15, Article 14392
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ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling
Author / Creator:Carozza, Jacqueline A. ; Cordova, Anthony F. ; Brown, Jenifer A. ; AlSaif, Yasmeen ; Böhnert, Volker ; Cao, Xujun ; Mardjuki, Rachel E. ; Skariah, Gemini ; Fernandez, Daniel ; Li, Lingyin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-05, Vol.119 (21), p.1-11
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ArticlesPeer ReviewedFull Text
Nuclear-localized cyclic nucleotide–gated channels mediate symbiotic calcium oscillations
Author / Creator:Charpentier, Myriam ; Sun, Jongho ; Martins, Teresa Vaz ; Radhakrishnan, Guru V. ; Findlay, Kim ; Soumpourou, Eleni ; Thouin, Julien ; Véry, Anne-Aliénor ; Sanders, Dale ; Morris, Richard J. ; Oldroyd, Giles E. D.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-05, Vol.352 (6289), p.1102-1105
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ArticlesPeer ReviewedFull Text
SLC19A1 transports immunoreactive cyclic dinucleotides
Author / Creator:Luteijn, Rutger D. ; Zaver, Shivam A. ; Gowen, Benjamin G. ; Wyman, Stacia K. ; Garelis, Nick E. ; Onia, Liberty ; McWhirter, Sarah M. ; Katibah, George E. ; Corn, Jacob E. ; Woodward, Joshua J. ; Raulet, David H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2019-09, Vol.573 (7774), p.434-438
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Select record 33
ArticlesPeer ReviewedFull Text
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
Author / Creator:Lama, Lodoe ; Adura, Carolina ; Xie, Wei ; Tomita, Daisuke ; Kamei, Taku ; Kuryavyi, Vitaly ; Gogakos, Tasos ; Steinberg, Joshua I. ; Miller, Michael ; Ramos-Espiritu, Lavoisier ; Asano, Yasutomi ; Hashizume, Shogo ; Aida, Jumpei ; Imaeda, Toshihiro ; Okamoto, Rei ; Jennings, Andy J. ; Michino, Mayako ; Kuroita, Takanobu ; Stamford, Andrew ; Gao, Pu ; Meinke, Peter ; Glickman, J. Fraser ; Patel, Dinshaw J. ; Tuschl, Thomas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-05, Vol.10 (1), p.2261-2261, Article 2261
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Select record 34
ArticlesPeer ReviewedFull Text
An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity
Author / Creator:Athukoralage, Januka S. ; McMahon, Stephen A. ; Zhang, Changyi ; Grüschow, Sabine ; Graham, Shirley ; Krupovic, Mart ; Whitaker, Rachel J. ; Gloster, Tracey M. ; White, Malcolm F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-01, Vol.577 (7791), p.572-575
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Select record 35
ArticlesPeer ReviewedFull Text
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Author / Creator:Ablasser, Andrea ; Schmid-Burgk, Jonathan L. ; Hemmerling, Inga ; Horvath, Gabor L. ; Schmidt, Tobias ; Latz, Eicke ; Hornung, Veit
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-11, Vol.503 (7477), p.530-534
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Select record 36
ArticlesPeer ReviewedFull Text
Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Author / Creator:Li, Lingyin ; Yin, Qian ; Kuss, Pia ; Maliga, Zoltan ; Millán, José L ; Wu, Hao ; Mitchison, Timothy J
Publisher:United States: Nature Publishing Group
Journal title:Nature chemical biology, 2014-12, Vol.10 (12), p.1043-1048
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Select record 37
ArticlesPeer ReviewedFull Text
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
Author / Creator:Jenson, Justin M. ; Li, Tuo ; Du, Fenghe ; Ea, Chee-Kwee ; Chen, Zhijian J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-04, Vol.616 (7956), p.326-331
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Select record 38
ArticlesPeer ReviewedFull Text
Two cGAS-like receptors induce antiviral immunity in Drosophila
Author / Creator:Holleufer, Andreas ; Winther, Kasper Grønbjerg ; Gad, Hans Henrik ; Ai, Xianlong ; Chen, Yuqiang ; Li, Lihua ; Wei, Ziming ; Deng, Huimin ; Liu, Jiyong ; Frederiksen, Ninna Ahlmann ; Simonsen, Bine ; Andersen, Line Lykke ; Kleigrewe, Karin ; Dalskov, Louise ; Pichlmair, Andreas ; Cai, Hua ; Imler, Jean-Luc ; Hartmann, Rune
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2021-09, Vol.597 (7874), p.114-118
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Select record 39
ArticlesPeer ReviewedFull Text
Cyclic nucleotide-induced helical structure activates a TIR immune effector
Author / Creator:Hogrel, Gaëlle ; Guild, Abbie ; Graham, Shirley ; Rickman, Hannah ; Grüschow, Sabine ; Bertrand, Quentin ; Spagnolo, Laura ; White, Malcolm F.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-08, Vol.608 (7924), p.808-812
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Select record 40
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Transmission of innate immune signaling by packaging of cGAMP in viral particles
Author / Creator:Gentili, Matteo ; Kowal, Joanna ; Tkach, Mercedes ; Satoh, Takeshi ; Lahaye, Xavier ; Conrad, Cécile ; Boyron, Marilyn ; Lombard, Bérangère ; Durand, Sylvère ; Kroemer, Guido ; Loew, Damarys ; Dalod, Marc ; Théry, Clotilde ; Manel, Nicolas
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-09, Vol.349 (6253), p.1232-1236
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STING directly activates autophagy to tune the innate immune response

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Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

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Activation of STING by targeting a pocket in the transmembrane domain

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Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

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Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells

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IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

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ENPP1’s regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling

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Nuclear-localized cyclic nucleotide–gated channels mediate symbiotic calcium oscillations

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SLC19A1 transports immunoreactive cyclic dinucleotides

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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

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An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

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Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence

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Two cGAS-like receptors induce antiviral immunity in Drosophila

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Cyclic nucleotide-induced helical structure activates a TIR immune effector

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Transmission of innate immune signaling by packaging of cGAMP in viral particles

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