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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2
Author / Creator:Pack, Lindsey R. ; Daigh, Leighton H. ; Chung, Mingyu ; Meyer, Tobias
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-06, Vol.12 (1), p.3356-3356, Article 3356
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Cyclin-dependent kinases
Author / Creator:Malumbres, Marcos
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology (Online Edition), 2014-06, Vol.15 (6), p.122-122, Article 122
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Lewis y Regulate Cell Cycle Related Factors in Ovarian Carcinoma Cell RMG-I in Vitro via ERK and Akt Signaling Pathways
Author / Creator:Liu, Dawo ; Liu, Juanjuan ; Lin, Bei ; Liu, Shuice ; Hou, Rui ; Hao, Yingying ; Liu, Qing ; Zhang, Shulan ; Iwamori, Masao
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2012-01, Vol.13 (1), p.828-839
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Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity
Author / Creator:Fatrai, Szabolcs ; Elghazi, Lynda ; Balcazar, Norman ; Cras-Méneur, Corentin ; Krits, Irina ; Kiyokawa, Hiroaki ; Bernal-Mizrachi, Ernesto
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2006-02, Vol.55 (2), p.318-325
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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK
Author / Creator:Brown, Nicholas R. ; Korolchuk, Svitlana ; Martin, Mathew P. ; Stanley, Will A. ; Moukhametzianov, Rouslan ; Noble, Martin E. M. ; Endicott, Jane A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2015-04, Vol.6 (1), p.6769-6769, Article 6769
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Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients
Author / Creator:Scaltriti, Maurizio ; Eichhorn, Pieter J ; Cortés, Javier ; Prudkin, Ludmila ; Aura, Claudia ; Jiménez, José ; Chandarlapaty, Sarat ; Serra, Violeta ; Prat, Aleix ; Ibrahim, Yasir H ; Guzmán, Marta ; Gili, Magui ; Rodríguez, Olga ; Rodríguez, Sonia ; Pérez, José ; Green, Simon R ; Mai, Sabine ; Rosen, Neal ; Hudis, Clifford ; Baselga, José
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (9), p.3761-3766
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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K
Author / Creator:Słabicki, Mikołaj ; Kozicka, Zuzanna ; Petzold, Georg ; Li, Yen-Der ; Manojkumar, Manisha ; Bunker, Richard D. ; Donovan, Katherine A. ; Sievers, Quinlan L. ; Koeppel, Jonas ; Suchyta, Dakota ; Sperling, Adam S. ; Fink, Emma C. ; Gasser, Jessica A. ; Wang, Li R. ; Corsello, Steven M. ; Sellar, Rob S. ; Jan, Max ; Gillingham, Dennis ; Scholl, Claudia ; Fröhling, Stefan ; Golub, Todd R. ; Fischer, Eric S. ; Thomä, Nicolas H. ; Ebert, Benjamin L.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-09, Vol.585 (7824), p.293-297
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Cell cycle regulation by long non-coding RNAs
Author / Creator:Kitagawa, Masatoshi ; Kitagawa, Kyoko ; Kotake, Yojiro ; Niida, Hiroyuki ; Ohhata, Tatsuya
Publisher:Basel: Springer-Verlag
Journal title:Cellular and molecular life sciences : CMLS, 2013-12, Vol.70 (24), p.4785-4794
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Cell cycle, CDKs and cancer: a changing paradigm
Author / Creator:Malumbres, Marcos ; Barbacid, Mariano
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Cancer, 2009-03, Vol.9 (3), p.153-166
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Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors
Author / Creator:Gomatou, Georgia ; Trontzas, Ioannis ; Ioannou, Stephanie ; Drizou, Maria ; Syrigos, Nikolaos ; Kotteas, Elias
Publisher:Dordrecht: Springer Netherlands
Journal title:Molecular biology reports, 2021-01, Vol.48 (1), p.915-925
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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival
Author / Creator:Wang, Haizhen ; Nicolay, Brandon N. ; Chick, Joel M. ; Gao, Xueliang ; Geng, Yan ; Ren, Hong ; Gao, Hui ; Yang, Guizhi ; Williams, Juliet A. ; Suski, Jan M. ; Keibler, Mark A. ; Sicinska, Ewa ; Gerdemann, Ulrike ; Haining, W. Nicholas ; Roberts, Thomas M. ; Polyak, Kornelia ; Gygi, Steven P. ; Dyson, Nicholas J. ; Sicinski, Piotr
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2017-06, Vol.546 (7658), p.426-430
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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation
Author / Creator:Tsytlonok, Maksym ; Sanabria, Hugo ; Wang, Yuefeng ; Felekyan, Suren ; Hemmen, Katherina ; Phillips, Aaron H. ; Yun, Mi-Kyung ; Waddell, M. Brett ; Park, Cheon-Gil ; Vaithiyalingam, Sivaraja ; Iconaru, Luigi ; White, Stephen W. ; Tompa, Peter ; Seidel, Claus A. M. ; Kriwacki, Richard
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-04, Vol.10 (1), p.1676-13, Article 1676
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Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability
Author / Creator:Zhan, Zhiyan ; Song, Lili ; Zhang, Weiwei ; Gu, Haihui ; Cheng, Haizi ; Zhang, Yingwen ; Yang, Yi ; Ji, Guangzhen ; Feng, Haizhong ; Cheng, Tao ; Li, Yanxin
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2019-03, Vol.10 (4), p.271-271, Article 271
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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers
Author / Creator:Vijayaraghavan, Smruthi ; Karakas, Cansu ; Doostan, Iman ; Chen, Xian ; Bui, Tuyen ; Yi, Min ; Raghavendra, Akshara S. ; Zhao, Yang ; Bashour, Sami I. ; Ibrahim, Nuhad K. ; Karuturi, Meghan ; Wang, Jing ; Winkler, Jeffrey D. ; Amaravadi, Ravi K. ; Hunt, Kelly K. ; Tripathy, Debu ; Keyomarsi, Khandan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-06, Vol.8 (1), p.15916-15916, Article 15916
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Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma
Author / Creator:AbuHammad, Shatha ; Cullinane, Carleen ; Martin, Claire ; Bacolas, Zoe ; Ward, Teresa ; Chen, Huiqin ; Slater, Alison ; Ardley, Kerry ; Kirby, Laura ; Chan, Keefe T. ; Brajanovski, Natalie ; Smith, Lorey K. ; Rao, Aparna D. ; Lelliott, Emily J. ; Kleinschmidt, Margarete ; Vergara, Ismael A. ; Papenfuss, Anthony T. ; Lau, Peter ; Ghosh, Prerana ; Haupt, Sue ; Haupt, Ygal ; Sanij, Elaine ; Poortinga, Gretchen ; Pearson, Richard B. ; Falk, Hendrik ; Curtis, David J. ; Stupple, Paul ; Devlin, Mark ; Street, Ian ; Davies, Michael A. ; McArthur, Grant A. ; Sheppard, Karen E.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (36), p.17990-18000
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SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling
Author / Creator:Barzegar, Mansoureh ; Ma, Shuang ; Zhang, Chao ; Chen, Xin ; Gu, Ying ; Shang, Chaowei ; Jiang, Xiaojuan ; Yang, Jiao ; Nathan, Cherie-Ann ; Yang, Shengyong ; Huang, Shile
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2017-10, Vol.117 (8), p.1154-1163
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Amniotic membrane‐derived cells inhibit proliferation of cancer cell lines by inducing cell cycle arrest
Author / Creator:Magatti, Marta ; Munari, Silvia ; Vertua, Elsa ; Parolini, Ornella
Publisher:England: John Wiley & Sons, Inc
Journal title:Journal of cellular and molecular medicine, 2012-09, Vol.16 (9), p.2208-2218
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hyperfused mitochondrial state achieved at G₁-S regulates cyclin E buildup and entry into S phase
Author / Creator:Mitra, Kasturi ; Wunder, Christian ; Roysam, Badrinath ; Lin, Gang ; Lippincott-Schwartz, Jennifer
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2009-07, Vol.106 (29), p.11960-11965
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A specific anti-cyclin D1 intrabody represses breast cancer cell proliferation by interrupting the cyclin D1–CDK4 interaction
Author / Creator:Zhao, Jialiang ; Wu, Yan ; Xiao, Tong ; Cheng, Cheng ; Zhang, Tong ; Gao, Ziyang ; Hu, Siyuan ; Ren, Ze ; Yu, Xinze ; Yang, Fang ; Li, Guiying
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2023-04, Vol.198 (3), p.555-568
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Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance
Author / Creator:Zhang, Jinfang ; Bu, Xia ; Wang, Haizhen ; Zhu, Yasheng ; Geng, Yan ; Nihira, Naoe Taira ; Tan, Yuyong ; Ci, Yanpeng ; Wu, Fei ; Dai, Xiangpeng ; Guo, Jianping ; Huang, Yu-Han ; Fan, Caoqi ; Ren, Shancheng ; Sun, Yinghao ; Freeman, Gordon J. ; Sicinski, Piotr ; Wei, Wenyi
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-01, Vol.553 (7686), p.91-95
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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2

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Cyclin-dependent kinases

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Lewis y Regulate Cell Cycle Related Factors in Ovarian Carcinoma Cell RMG-I in Vitro via ERK and Akt Signaling Pathways

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Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity

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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

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Cyclin E amplification/overexpression is a mechanism of trastuzumab resistance in HER2⁺ breast cancer patients

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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K

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Cell cycle regulation by long non-coding RNAs

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Cell cycle, CDKs and cancer: a changing paradigm

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Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors

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The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

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Dynamic anticipation by Cdk2/Cyclin A-bound p27 mediates signal integration in cell cycle regulation

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Absence of cyclin-dependent kinase inhibitor p27 or p18 increases efficiency of iPSC generation without induction of iPSC genomic instability

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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

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Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

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SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling

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Amniotic membrane‐derived cells inhibit proliferation of cancer cell lines by inducing cell cycle arrest

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hyperfused mitochondrial state achieved at G₁-S regulates cyclin E buildup and entry into S phase

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A specific anti-cyclin D1 intrabody represses breast cancer cell proliferation by interrupting the cyclin D1–CDK4 interaction

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Cyclin D–CDK4 kinase destabilizes PD-L1 via cullin 3–SPOP to control cancer immune surveillance

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