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Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk
Author / Creator:Chiou, Joshua ; Zeng, Chun ; Cheng, Zhang ; Han, Jee Yun ; Schlichting, Michael ; Miller, Michael ; Mendez, Robert ; Huang, Serina ; Wang, Jinzhao ; Sui, Yinghui ; Deogaygay, Allison ; Okino, Mei-Lin ; Qiu, Yunjiang ; Sun, Ying ; Kudtarkar, Parul ; Fang, Rongxin ; Preissl, Sebastian ; Sander, Maike ; Gorkin, David U. ; Gaulton, Kyle J.
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2021-04, Vol.53 (4), p.455-466
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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Author / Creator:Omar-Hmeadi, Muhmmad ; Lund, Per-Eric ; Gandasi, Nikhil R. ; Tengholm, Anders ; Barg, Sebastian
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-04, Vol.11 (1), p.1896-1896, Article 1896
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Organisation of the human pancreas in health and in diabetes
Author / Creator:Atkinson, Mark A. ; Campbell-Thompson, Martha ; Kusmartseva, Irina ; Kaestner, Klaus H.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Diabetologia, 2020-10, Vol.63 (10), p.1966-1973
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PAX6 maintains β cell identity by repressing genes of alternative islet cell types
Author / Creator:Swisa, Avital ; Avrahami, Dana ; Eden, Noa ; Zhang, Jia ; Feleke, Eseye ; Dahan, Tehila ; Cohen-Tayar, Yamit ; Stolovich-Rain, Miri ; Kaestner, Klaus H. ; Glaser, Benjamin ; Ashery-Padan, Ruth ; Dor, Yuval
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2017-01, Vol.127 (1), p.230-243
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The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells
Author / Creator:Courtney, Monica ; Gjernes, Elisabet ; Druelle, Noémie ; Ravaud, Christophe ; Vieira, Andhira ; Ben-Othman, Nouha ; Pfeifer, Anja ; Avolio, Fabio ; Leuckx, Gunter ; Lacas-Gervais, Sandra ; Burel-Vandenbos, Fanny ; Ambrosetti, Damien ; Hecksher-Sorensen, Jacob ; Ravassard, Philippe ; Heimberg, Harry ; Mansouri, Ahmed ; Collombat, Patrick
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2013-10, Vol.9 (10), p.e1003934-e1003934
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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
Author / Creator:Wang, May-Yun ; Dean, E. Danielle ; Quittner-Strom, Ezekiel ; Zhu, Yi ; Chowdhury, Kamrul H. ; Zhang, Zhuzhen ; Zhao, Shangang ; Li, Na ; Ye, Reshing ; Lee, Young ; Zhang, Yiyi ; Chen, Shiuhwei ; Yu, Xinxin ; Leonard, Derek C. ; Poffenberger, Greg ; Von Deylen, Alison ; McCorkle, S. Kay ; Schlegel, Amnon ; Sloop, Kyle W. ; Efanov, Alexander M. ; Gimeno, Ruth E. ; Scherer, Philipp E. ; Powers, Alvin C. ; Unger, Roger H. ; Holland, William L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (9), p.1-8
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Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
Author / Creator:Mezza, Teresa ; Muscogiuri, Giovanna ; Sorice, Gian Pio ; Clemente, Gennaro ; Hu, Jiang ; Pontecorvi, Alfredo ; Holst, Jens J. ; Giaccari, Andrea ; Kulkarni, Rohit N.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2014-03, Vol.63 (3), p.994-1007
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α-cell glucokinase suppresses glucose-regulated glucagon secretion
Author / Creator:Basco, Davide ; Zhang, Quan ; Salehi, Albert ; Tarasov, Andrei ; Dolci, Wanda ; Herrera, Pedro ; Spiliotis, Ioannis ; Berney, Xavier ; Tarussio, David ; Rorsman, Patrik ; Thorens, Bernard
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-02, Vol.9 (1), p.546-9, Article 546
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Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor
Author / Creator:Longuet, Christine ; Robledo, Ana M ; Dean, E Danielle ; Dai, Chunhua ; Ali, Safina ; McGuinness, Ian ; de Chavez, Vincent ; Vuguin, Patricia M ; Charron, Maureen J ; Powers, Alvin C ; Drucker, Daniel J
Publisher:United States: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-04, Vol.62 (4), p.1196-1205
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ArticlesPeer ReviewedFull Text
Liver Transplantation in a Woman with Mahvash Disease
Author / Creator:Robbins, Justin ; Halegoua-DeMarzio, Dina ; Basu Mallick, Atrayee ; Vijayvergia, Namrata ; Ganetzky, Rebecca ; Lavu, Harish ; Giri, Veda N. ; Miller, Jeffrey ; Maley, Warren ; Shah, Ashesh P. ; DiMeglio, Matthew ; Ambelil, Manju ; Yu, Run ; Sato, Takami ; Lefler, Daniel S.
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2023-11, Vol.389 (21), p.1972-1978
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Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation
Author / Creator:Miki, Atsushi ; Ricordi, Camillo ; Sakuma, Yasunaru ; Yamamoto, Toshiyuki ; Misawa, Ryosuke ; Mita, Atsuyoshi ; Molano, Ruth D. ; Vaziri, Nosratola D. ; Pileggi, Antonello ; Ichii, Hirohito
Publisher:United States: Public Library of Science
Journal title:PloS one, 2018-05, Vol.13 (5), p.e0196570-e0196570
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Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice
Author / Creator:Jia, Jianxin ; Bai, Xuanxuan ; Kang, Qi ; Jiang, Fuquan ; Wong, F. Susan ; Jin, Quanwen ; Li, Mingyu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2025-03, Vol.16 (1), p.2473-17, Article 2473
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Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice
Author / Creator:Yin, Qinglei ; Ni, Qicheng ; Wang, Yichen ; Zhang, Hongli ; Li, Wenyi ; Nie, Aifang ; Wang, Shu ; Gu, Yanyun ; Wang, Qidi ; Ning, Guang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-05, Vol.11 (1), p.2538-2538, Article 2538
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Pancreatic alpha cell mass in European subjects with type 2 diabetes
Author / Creator:Henquin, J. C. ; Rahier, J.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Diabetologia, 2011-07, Vol.54 (7), p.1720-1725
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FAP expression in alpha cells of Langherhans insulae—implications for FAPI radiopharmaceuticals’ use
Author / Creator:Kirienko, Margarita ; Centonze, Giovanni ; Sabella, Giovanna ; Sollai, Mauro ; Sollini, Martina ; Lan, Xiaoli ; Chen, Haojun ; Terracciano, Luigi ; Seregni, Ettore ; Milione, Massimo
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:European journal of nuclear medicine and molecular imaging, 2023-08, Vol.50 (10), p.3042-3049
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Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs
Author / Creator:Gharib, Sina A. ; Vemireddy, Rachna ; Castillo, Joseph J. ; Fountaine, Brendy S. ; Bammler, Theo K. ; MacDonald, James W. ; Hull-Meichle, Rebecca L. ; Zraika, Sakeneh
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-10, Vol.14 (1), p.25689-14, Article 25689
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Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans
Author / Creator:Sharma, Anu ; Varghese, Ron T ; Shah, Meera ; Man, Chiara Dalla ; Cobelli, Claudio ; Rizza, Robert A ; Bailey, Kent R ; Vella, Adrian
Publisher:United States: Copyright Oxford University Press
Journal title:The journal of clinical endocrinology and metabolism, 2018-01, Vol.103 (1), p.314-319
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β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion
Author / Creator:Robson-Doucette, Christine A. ; Sultan, Sobia ; Allister, Emma M. ; Wikstrom, Jakob D. ; Koshkin, Vasilij ; Bhattacharjee, Alpana ; Prentice, Kacey J. ; Sereda, Samuel B. ; Shirihai, Orian S. ; Wheeler, Michael B.
Publisher:United States: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2011-11, Vol.60 (11), p.2710-2719
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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells
Author / Creator:Lee, Young ; Berglund, Eric D. ; Yu, Xinxin ; Wang, May-Yun ; Evans, Matthew R. ; Scherer, Philipp E. ; Holland, William L. ; Charron, Maureen J. ; Roth, Michael G. ; Unger, Roger H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (36), p.13217-13222
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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells
Author / Creator:Mohan, Shruti ; Lafferty, Ryan ; Tanday, Neil ; Flatt, Peter R. ; Moffett, R. Charlotte ; Irwin, Nigel
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-12, Vol.16 (12), p.e0261608-e0261608
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Showing 1 to 20 of 51 results

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Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk

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Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

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Organisation of the human pancreas in health and in diabetes

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PAX6 maintains β cell identity by repressing genes of alternative islet cell types

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The Inactivation of Arx in Pancreatic α-Cells Triggers Their Neogenesis and Conversion into Functional β-Like Cells

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Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets

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Insulin Resistance Alters Islet Morphology in Nondiabetic Humans

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α-cell glucokinase suppresses glucose-regulated glucagon secretion

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Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor

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Liver Transplantation in a Woman with Mahvash Disease

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Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation

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Blockade of glucagon receptor induces α-cell hypersecretion by hyperaminoacidemia in mice

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Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice

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Pancreatic alpha cell mass in European subjects with type 2 diabetes

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FAP expression in alpha cells of Langherhans insulae—implications for FAPI radiopharmaceuticals’ use

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Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs

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Impaired Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans

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β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

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Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

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