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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling
Author / Creator:Reinhardt, Peter ; Glatza, Michael ; Hemmer, Kathrin ; Tsytsyura, Yaroslav ; Thiel, Cora S ; Höing, Susanne ; Moritz, Sören ; Parga, Juan A ; Wagner, Lydia ; Bruder, Jan M ; Wu, Guangming ; Schmid, Benjamin ; Röpke, Albrecht ; Klingauf, Jürgen ; Schwamborn, Jens C ; Gasser, Thomas ; Schöler, Hans R ; Sterneckert, Jared
Publisher:United States: Public Library of Science
Journal title:PloS one, 2013-03, Vol.8 (3), p.e59252-e59252
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TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
Author / Creator:Fu, Bishi ; Wang, Lingyan ; Ding, Hao ; Schwamborn, Jens C ; Li, Shitao ; Dorf, Martin E
Publisher:United States: Public Library of Science
Journal title:PLoS pathogens, 2015-06, Vol.11 (6), p.e1004960-e1004960
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Automated microfluidic cell culture of stem cell derived dopaminergic neurons
Author / Creator:Kane, Khalid I. W. ; Moreno, Edinson Lucumi ; Hachi, Siham ; Walter, Moriz ; Jarazo, Javier ; Oliveira, Miguel A. P. ; Hankemeier, Thomas ; Vulto, Paul ; Schwamborn, Jens C. ; Thoma, Martin ; Fleming, Ronan M. T.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-02, Vol.9 (1), p.1796-1796, Article 1796
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Modeling Parkinson’s disease in midbrain-like organoids
Author / Creator:Smits, Lisa M. ; Reinhardt, Lydia ; Reinhardt, Peter ; Glatza, Michael ; Monzel, Anna S. ; Stanslowsky, Nancy ; Rosato-Siri, Marcelo D. ; Zanon, Alessandra ; Antony, Paul M. ; Bellmann, Jessica ; Nicklas, Sarah M. ; Hemmer, Kathrin ; Qing, Xiaobing ; Berger, Emanuel ; Kalmbach, Norman ; Ehrlich, Marc ; Bolognin, Silvia ; Hicks, Andrew A. ; Wegner, Florian ; Sterneckert, Jared L. ; Schwamborn, Jens C.
Publisher:London: Nature Publishing Group UK
Journal title:NPJ Parkinson's Disease, 2019-04, Vol.5 (1), p.5-5, Article 5
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Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
Author / Creator:Smits, Lisa M. ; Magni, Stefano ; Kinugawa, Kaoru ; Grzyb, Kamil ; Luginbühl, Joachim ; Sabate-Soler, Sonia ; Bolognin, Silvia ; Shin, Jay W. ; Mori, Eiichiro ; Skupin, Alexander ; Schwamborn, Jens C.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Cell and tissue research, 2020-12, Vol.382 (3), p.463-476
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Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening
Author / Creator:Boussaad, Ibrahim ; Cruciani, Gérald ; Bolognin, Silvia ; Antony, Paul ; Dording, Claire M. ; Kwon, Yong-Jun ; Heutink, Peter ; Fava, Eugenio ; Schwamborn, Jens C. ; Krüger, Rejko
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-01, Vol.11 (1), p.1439-1439, Article 1439
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PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons
Author / Creator:Brown, Sarah J. ; Boussaad, Ibrahim ; Jarazo, Javier ; Fitzgerald, Julia C. ; Antony, Paul ; Keatinge, Marcus ; Blechman, Janna ; Schwamborn, Jens C. ; Krüger, Rejko ; Placzek, Marysia ; Bandmann, Oliver
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-03, Vol.11 (1), p.6617-6617, Article 6617
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Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella
Author / Creator:Mendonça, Liliana S. ; Henriques, Daniel ; Fernandes, Vanessa ; Moreira, Ricardo ; Brás, João ; Duarte, Sónia ; Schwamborn, Jens C. ; de Almeida, Luís Pereira
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-02, Vol.14 (1), p.3236-3236, Article 3236
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3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
Author / Creator:Bolognin, Silvia ; Fossépré, Marie ; Qing, Xiaobing ; Jarazo, Javier ; Ščančar, Janez ; Moreno, Edinson Lucumi ; Nickels, Sarah L. ; Wasner, Kobi ; Ouzren, Nassima ; Walter, Jonas ; Grünewald, Anne ; Glaab, Enrico ; Salamanca, Luis ; Fleming, Ronan M. T. ; Antony, Paul M. A. ; Schwamborn, Jens C.
Publisher:Germany: John Wiley & Sons, Inc
Journal title:Advanced science, 2019-01, Vol.6 (1), p.1800927-n/a
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Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors
Author / Creator:Mavrommatis, Lampros ; Jeong, Hyun-Woo ; Kindler, Urs ; Gomez-Giro, Gemma ; Kienitz, Marie-Cecile ; Stehling, Martin ; Psathaki, Olympia E ; Zeuschner, Dagmar ; Bixel, M Gabriele ; Han, Dong ; Morosan-Puopolo, Gabriela ; Gerovska, Daniela ; Yang, Ji Hun ; Kim, Jeong Beom ; Arauzo-Bravo, Marcos J ; Schwamborn, Jens C ; Hahn, Stephan A ; Adams, Ralf H ; Schöler, Hans R ; Vorgerd, Matthias ; Brand-Saberi, Beate ; Zaehres, Holm
Publisher:Cambridge: eLife Science Publications, Ltd
Journal title:eLife, 2023-11, Vol.12
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ArticlesPeer ReviewedFull Text
Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
Author / Creator:Walvekar, Adhish S ; Warmoes, Marc ; Cheung, Dean ; Sikora, Tim ; Seyedkatouli, Najmesadat ; Gomez-Giro, Gemma ; Perrone, Sebastian ; Dengler, Lisa ; Unger, François ; Santos, Bruno F R ; Gavotto, Floriane ; Dong, Xiangyi ; Becker-Kettern, Julia ; Kwon, Yong-Jun ; Jäger, Christian ; Schwamborn, Jens C ; Van Bergen, Nicole J ; Christodoulou, John ; Linster, Carole L
Publisher:England: BioMed Central
Journal title:Cellular & molecular biology letters, 2025-01, Vol.30 (1), p.3-40, Article 3
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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
Author / Creator:Gomez-Giro, Gemma ; Arias-Fuenzalida, Jonathan ; Jarazo, Javier ; Zeuschner, Dagmar ; Ali, Muhammad ; Possemis, Nina ; Bolognin, Silvia ; Halder, Rashi ; Jäger, Christian ; Kuper, Willemijn F E ; van Hasselt, Peter M ; Zaehres, Holm ; Del Sol, Antonio ; van der Putten, Herman ; Schöler, Hans R ; Schwamborn, Jens C
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2019-12, Vol.7 (1), p.222-222, Article 222
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TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration
Author / Creator:Nicklas, Sarah ; Otto, Anthony ; Wu, Xiaoli ; Miller, Pamela ; Stelzer, Sandra ; Wen, Yefei ; Kuang, Shihuan ; Wrogemann, Klaus ; Patel, Ketan ; Ding, Hao ; Schwamborn, Jens C
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-01, Vol.7 (1), p.e30445-e30445
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Cystatin C Secretion in Blood Derivatives and Cellular Models of Idiopathic Parkinson's Disease
Author / Creator:Mommaerts, Kathleen ; Monzel, Anna S ; Zagare, Alise ; Nickels, Sarah L ; Diederich, Nico J ; Longhino, Laura ; Mathieson, William ; Antony, Paul M A ; Betsou, Fay ; Schwamborn, Jens C
Publisher:United States: John Wiley & Sons, Inc
Journal title:Parkinson's disease, 2025-01, Vol.2025 (1), p.5149071
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Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus
Author / Creator:Imielski, Yvonne ; Schwamborn, Jens C ; Lüningschrör, Patrick ; Heimann, Peter ; Holzberg, Magdalena ; Werner, Hendrikje ; Leske, Oliver ; Püschel, Andreas W ; Memet, Sylvie ; Heumann, Rolf ; Israel, Alain ; Kaltschmidt, Christian ; Kaltschmidt, Barbara
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e30838
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Deciphering shared molecular dysregulation across Parkinson’s disease variants using a multi-modal network-based data integration and analysis
Author / Creator:Zagare, Alise ; Balaur, Irina ; Rougny, Adrien ; Saraiva, Claudia ; Gobin, Matthieu ; Monzel, Anna S. ; Ghosh, Soumyabrata ; Satagopam, Venkata P. ; Schwamborn, Jens C.
Publisher:London: Nature Publishing Group UK
Journal title:NPJ Parkinson's Disease, 2025-03, Vol.11 (1), p.63-14, Article 63
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Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model
Author / Creator:Mészáros, Mária ; Phan, Thi Ha My ; Vigh, Judit P ; Porkoláb, Gergő ; Kocsis, Anna ; Szecskó, Anikó ; Páli, Emese K ; Cser, Nárcisz M ; Polgár, Tamás F ; Kecskeméti, Gábor ; Walter, Fruzsina R ; Schwamborn, Jens C ; Janáky, Tamás ; Jan, Jeng-Shiung ; Veszelka, Szilvia ; Deli, Mária A
Publisher:England: BioMed Central Ltd
Journal title:Fluids and barriers of the CNS, 2025-02, Vol.22 (1), p.18-23, Article 18
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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson's disease pathology
Author / Creator:Zagare, Alise ; Kurlovics, Janis ; Almeida, Catarina ; Ferrante, Daniele ; Frangenberg, Daniela ; Vitali, Armelle ; Gomez-Giro, Gemma ; Jäger, Christian ; Antony, Paul ; Halder, Rashi ; Krüger, Rejko ; Glaab, Enrico ; Stalidzans, Egils ; Arena, Giuseppe ; Schwamborn, Jens C
Publisher:England: SAGE Publications
Journal title:Journal of tissue engineering, 2025-01, Vol.16, p.20417314241295928
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Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
Author / Creator:Jan, Asad ; Jansonius, Brandon ; Delaidelli, Alberto ; Bhanshali, Forum ; An, Yi Andy ; Ferreira, Nelson ; Smits, Lisa M ; Negri, Gian Luca ; Schwamborn, Jens C ; Jensen, Poul H ; Mackenzie, Ian R ; Taubert, Stefan ; Sorensen, Poul H
Publisher:England: BioMed Central Ltd
Journal title:Acta neuropathologica communications, 2018-07, Vol.6 (1), p.54-17, Article 54
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Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids
Author / Creator:Rosety, Isabel ; Zagare, Alise ; Saraiva, Claudia ; Nickels, Sarah ; Antony, Paul ; Almeida, Catarina ; Glaab, Enrico ; Halder, Rashi ; Velychko, Sergiy ; Rauen, Thomas ; Schöler, Hans R. ; Bolognin, Silvia ; Sauter, Thomas ; Jarazo, Javier ; Krüger, Rejko ; Schwamborn, Jens C.
Publisher:London: Nature Publishing Group UK
Journal title:NPJ Parkinson's Disease, 2023-12, Vol.9 (1), p.166-166, Article 166
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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling

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TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

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Automated microfluidic cell culture of stem cell derived dopaminergic neurons

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Modeling Parkinson’s disease in midbrain-like organoids

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Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids

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Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening

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PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

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Graft-derived neurons and bystander effects are maintained for six months after human iPSC-derived NESC transplantation in mice’s cerebella

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3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

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Human skeletal muscle organoids model fetal myogenesis and sustain uncommitted PAX7 myogenic progenitors

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Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells

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Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis

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TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration

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Cystatin C Secretion in Blood Derivatives and Cellular Models of Idiopathic Parkinson's Disease

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Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

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Deciphering shared molecular dysregulation across Parkinson’s disease variants using a multi-modal network-based data integration and analysis

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Alanine and glutathione targeting of dopamine- or ibuprofen-coupled polypeptide nanocarriers increases both crossing and protective effects on a blood-brain barrier model

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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson's disease pathology

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Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity

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Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids

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