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ArticlesPeer ReviewedFull Text
KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins
Author / Creator:Marrone, Giusi ; Maeso-Díaz, Raquel ; García-Cardena, Guillermo ; Abraldes, Juan G ; García-Pagán, Juan Carlos ; Bosch, Jaime ; Gracia-Sancho, Jordi
Publisher:England: BMJ Publishing Group LTD
Journal title:Gut, 2015-09, Vol.64 (9), p.1434-1443
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Niosomal delivery of simvastatin to MDA-MB-231 cancer cells
Author / Creator:Akbarzadeh, Iman ; Saremi Poor, Anita ; Yaghmaei, Soheila ; Norouzian, Dariush ; Noorbazargan, Hassan ; Saffar, Samaneh ; Ahangari Cohan, Reza ; Bakhshandeh, Haleh
Publisher:England: Taylor & Francis
Journal title:Drug development and industrial pharmacy, 2020-09, Vol.46 (9), p.1535-1549
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Simvastatin induced ferroptosis for triple-negative breast cancer therapy
Author / Creator:Yao, Xianxian ; Xie, Ruihong ; Cao, Yongbin ; Tang, Jing ; Men, Yongzhi ; Peng, Haibao ; Yang, Wuli
Publisher:England: BioMed Central Ltd
Journal title:Journal of nanobiotechnology, 2021-10, Vol.19 (1), p.311-14, Article 311
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Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis
Author / Creator:Feng, Jiao ; Dai, Weiqi ; Mao, Yuqing ; Wu, Liwei ; Li, Jingjing ; Chen, Kan ; Yu, Qiang ; Kong, Rui ; Li, Sainan ; Zhang, Jie ; Ji, Jie ; Wu, Jianye ; Mo, Wenhui ; Xu, Xuanfu ; Guo, Chuanyong
Publisher:England: BioMed Central Ltd
Journal title:Journal of experimental & clinical cancer research, 2020-01, Vol.39 (1), p.24-18, Article 24
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Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised,...
Author / Creator:Chan, Dennis, PhD ; Binks, Sophie, MRCP ; Nicholas, Jennifer M, PhD ; Frost, Chris, Prof ; Cardoso, M Jorge, PhD ; Ourselin, Sebastien, Prof ; Wilkie, David, MA ; Nicholas, Richard, PhD ; Chataway, Jeremy, Dr
Publisher:England: Elsevier Ltd
Journal title:Lancet neurology, 2017-08, Vol.16 (8), p.591-600
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Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials
Author / Creator:Pienkos, Shaun M ; Moore, Andrew R ; Guan, Jiazhen ; Levitt, Joseph E ; Matthay, Michael A ; Baron, Rebecca M ; Conlon, John ; McAuley, Daniel F ; O'Kane, Cecilia M ; Rogers, Angela J
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2023-03, Vol.27 (1), p.126-9, Article 126
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A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy
Author / Creator:Whitehead, Nicholas P. ; Kim, Min Jeong ; Bible, Kenneth L. ; Adams, Marvin E. ; Froehner, Stanley C.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (41), p.12864-12869
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A statin-dependent QTL for GATM expression is associated with statin-induced myopathy
Author / Creator:Mangravite, Lara M. ; Engelhardt, Barbara E. ; Medina, Marisa W. ; Smith, Joshua D. ; Brown, Christopher D. ; Chasman, Daniel I. ; Mecham, Brigham H. ; Howie, Bryan ; Shim, Heejung ; Naidoo, Devesh ; Feng, QiPing ; Rieder, Mark J. ; Chen, Yii.-Der I. ; Rotter, Jerome I. ; Ridker, Paul M. ; Hopewell, Jemma C. ; Parish, Sarah ; Armitage, Jane ; Collins, Rory ; Wilke, Russell A. ; Nickerson, Deborah A. ; Stephens, Matthew ; Krauss, Ronald M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2013-10, Vol.502 (7471), p.377-380
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Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions
Author / Creator:Kulshreshtha, Ankur ; Singh, Swati ; Ahmad, Mohd ; Khanna, Kritika ; Ahmad, Tanveer ; Agrawal, Anurag ; Ghosh, Balaram
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-11, Vol.9 (1), p.16373-10, Article 16373
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Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial
Author / Creator:Boyle, Andrew James ; Ferris, Peter ; Bradbury, Ian ; Conlon, John ; Shankar-Hari, Manu ; Rogers, Angela J ; O'Kane, Cecilia M ; McAuley, Daniel F
Publisher:England: BioMed Central Ltd
Journal title:Critical care (London, England), 2022-06, Vol.26 (1), p.164-164, Article 164
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Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells
Author / Creator:Wang, Sin-Ting ; Ho, Hsiu J ; Lin, Jaw-Town ; Shieh, Jeng-Jer ; Wu, Chun-Ying
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2017-02, Vol.8 (2), p.e2626-e2626
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Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis
Author / Creator:Chou, Cheng-Wei ; Lin, Ching-Heng ; Hsiao, Tzu-Hung ; Lo, Chia-Chien ; Hsieh, Chih-Ying ; Huang, Cheng-Chung ; Sher, Yuh-Pyng
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-12, Vol.9 (1), p.20403-12, Article 20403
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ArticlesPeer ReviewedFull Text
Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma
Author / Creator:Yu, Zhuo ; Guo, Jianfeng ; Liu, Yun ; Wang, Menglin ; Liu, Zhengsheng ; Gao, Yueqiu ; Huang, Leaf
Publisher:England: BioMed Central Ltd
Journal title:Journal of nanobiotechnology, 2022-01, Vol.20 (1), p.9-16, Article 9
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Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells
Author / Creator:Alizadeh, Javad ; Zeki, Amir A. ; Mirzaei, Nima ; Tewary, Sandipan ; Rezaei Moghadam, Adel ; Glogowska, Aleksandra ; Nagakannan, Pandian ; Eftekharpour, Eftekhar ; Wiechec, Emilia ; Gordon, Joseph W. ; Xu, Fred. Y. ; Field, Jared T. ; Yoneda, Ken Y. ; Kenyon, Nicholas J. ; Hashemi, Mohammad ; Hatch, Grant M. ; Hombach-Klonisch, Sabine ; Klonisch, Thomas ; Ghavami, Saeid
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-03, Vol.7 (1), p.44841-44841, Article 44841
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ArticlesPeer ReviewedFull Text
Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity
Author / Creator:Pecoraro, Michela ; Marzocco, Stefania ; Belvedere, Raffaella ; Petrella, Antonello ; Franceschelli, Silvia ; Popolo, Ada
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2023-04, Vol.24 (8), p.7573
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Metformin and simvastatin synergistically suppress endothelin 1‐induced hypoxia and angiogenesis in multiple cancer types
Author / Creator:Liu, Jie ; Wang, Huxia ; Zhang, Miao ; Li, Yazhao ; Wang, Ruiqi ; Chen, He ; Wang, Bo ; Gao, Xiaoqian ; Song, Shaoran ; Wang, Yaochun ; Ren, Yu ; Li, Juan ; Liu, Peijun
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2023-02, Vol.114 (2), p.640-653
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Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF‐1α‐induced pro‐angiogenic factor
Author / Creator:Wang, Ji‐Chang ; Li, Xiong‐Xiong ; Sun, Xin ; Li, Guang‐Yue ; Sun, Jing‐Lan ; Ye, Yuan‐Peng ; Cong, Long‐Long ; Li, Wei‐Ming ; Lu, Shao‐Ying ; Feng, Jun ; Liu, Pei‐Jun
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2018-05, Vol.109 (5), p.1627-1637
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Role of Simvastatin on fracture healing and osteoporosis: a systematic review on in vivo investigations
Author / Creator:Moshiri, Ali ; Sharifi, Ali Mohammad ; Oryan, Ahmad
Publisher:Australia: Blackwell Publishing Ltd
Journal title:Clinical and experimental pharmacology & physiology, 2016-07, Vol.43 (7), p.659-684
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Simvastatin Inhibits Wnt/β-Catenin Pathway in Uterine Leiomyoma
Author / Creator:El Sabeh, Malak ; Saha, Subbroto Kumar ; Afrin, Sadia ; Borahay, Mostafa A
Publisher:US: Oxford University Press
Journal title:Endocrinology (Philadelphia), 2021-12, Vol.162 (12)
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Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression
Author / Creator:Chen, Yun-Rong ; Xiang, Xu-Dong ; Sun, Fei ; Xiao, Bo-Wen ; Yan, Mu-Yun ; Peng, Biao ; Liu, Da
Publisher:United States: Hindawi
Journal title:Oxidative medicine and cellular longevity, 2023, Vol.2023, p.1493684-13
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Showing 1 to 20 of 789 results

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KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins

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Niosomal delivery of simvastatin to MDA-MB-231 cancer cells

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Simvastatin induced ferroptosis for triple-negative breast cancer therapy

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Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis

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Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised,...

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Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials

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A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy

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A statin-dependent QTL for GATM expression is associated with statin-induced myopathy

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Simvastatin mediates inhibition of exosome synthesis, localization and secretion via multicomponent interventions

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Baseline plasma IL-18 may predict simvastatin treatment response in patients with ARDS: a secondary analysis of the HARP-2 randomised clinical trial

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Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells

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Therapeutic effects of statins against lung adenocarcinoma via p53 mutant-mediated apoptosis

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Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma

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Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells

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Simvastatin Reduces Doxorubicin-Induced Cardiotoxicity: Effects beyond Its Antioxidant Activity

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Metformin and simvastatin synergistically suppress endothelin 1‐induced hypoxia and angiogenesis in multiple cancer types

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Activation of AMPK by simvastatin inhibited breast tumor angiogenesis via impeding HIF‐1α‐induced pro‐angiogenic factor

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Role of Simvastatin on fracture healing and osteoporosis: a systematic review on in vivo investigations

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Simvastatin Inhibits Wnt/β-Catenin Pathway in Uterine Leiomyoma

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Simvastatin Reduces NETosis to Attenuate Severe Asthma by Inhibiting PAD4 Expression

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