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40 results for Autophagy-Related+Proteins+-+chemistry

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ArticlesPeer ReviewedFull Text
Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion
Author / Creator:Matoba, Kazuaki ; Kotani, Tetsuya ; Tsutsumi, Akihisa ; Tsuji, Takuma ; Mori, Takaharu ; Noshiro, Daisuke ; Sugita, Yuji ; Nomura, Norimichi ; Iwata, So ; Ohsumi, Yoshinori ; Fujimoto, Toyoshi ; Nakatogawa, Hitoshi ; Kikkawa, Masahide ; Noda, Nobuo N.
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-12, Vol.27 (12), p.1185-1193
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Phase separation organizes the site of autophagosome formation
Author / Creator:Fujioka, Yuko ; Alam, Jahangir Md ; Noshiro, Daisuke ; Mouri, Kazunari ; Ando, Toshio ; Okada, Yasushi ; May, Alexander I. ; Knorr, Roland L. ; Suzuki, Kuninori ; Ohsumi, Yoshinori ; Noda, Nobuo N.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-02, Vol.578 (7794), p.301-305
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Structure, lipid scrambling activity and role in autophagosome formation of ATG9A
Author / Creator:Maeda, Shintaro ; Yamamoto, Hayashi ; Kinch, Lisa N. ; Garza, Christina M. ; Takahashi, Satoru ; Otomo, Chinatsu ; Grishin, Nick V. ; Forli, Stefano ; Mizushima, Noboru ; Otomo, Takanori
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2020-12, Vol.27 (12), p.1194-1201
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Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex
Author / Creator:Chowdhury, Saikat ; Otomo, Chinatsu ; Leitner, Alexander ; Ohashi, Kazuto ; Aebersold, Ruedi ; Lander, Gabriel C. ; Otomo, Takanori
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-10, Vol.115 (42), p.E9792-E9801
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Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation
Author / Creator:Zhou, Zixuan ; Liu, Jianping ; Fu, Tao ; Wu, Ping ; Peng, Chao ; Gong, Xinyu ; Wang, Yingli ; Zhang, Mingfang ; Li, Ying ; Wang, Yaru ; Xu, Xiaolong ; Li, Miao ; Pan, Lifeng
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1570-1570, Article 1570
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WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy
Author / Creator:Bakula, Daniela ; Müller, Amelie J. ; Zuleger, Theresia ; Takacs, Zsuzsanna ; Franz-Wachtel, Mirita ; Thost, Ann-Katrin ; Brigger, Daniel ; Tschan, Mario P. ; Frickey, Tancred ; Robenek, Horst ; Macek, Boris ; Proikas-Cezanne, Tassula
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15637-15637, Article 15637
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Oxidation of Atg3 and Atg7 mediates inhibition of autophagy
Author / Creator:Frudd, Karen ; Burgoyne, Thomas ; Burgoyne, Joseph Robert
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-01, Vol.9 (1), p.95-15, Article 95
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Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy
Author / Creator:Zhou, Changqian ; Ma, Kaili ; Gao, Ruize ; Mu, Chenglong ; Chen, Linbo ; Liu, Qiangqiang ; Luo, Qian ; Feng, Du ; Zhu, Yushan ; Chen, Quan
Publisher:London: Nature Publishing Group UK
Journal title:Cell research, 2017-02, Vol.27 (2), p.184-201
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Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes
Author / Creator:Mochida, Keisuke ; Yamasaki, Akinori ; Matoba, Kazuaki ; Kirisako, Hiromi ; Noda, Nobuo N. ; Nakatogawa, Hitoshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3306-3306, Article 3306
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Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I
Author / Creator:Young, Lindsey N. ; Goerdeler, Felix ; Hurley, James H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (43), p.21508-21513
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Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD
Author / Creator:Su, Ming-Yuan ; Fromm, Simon A. ; Zoncu, Roberto ; Hurley, James H.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-09, Vol.585 (7824), p.251-255
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Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex
Author / Creator:Bhargava, Hersh K. ; Tabata, Keisuke ; Byck, Jordan M. ; Hamasaki, Maho ; Farrell, Daniel P. ; Anishchenko, Ivan ; DiMaio, Frank ; Im, Young Jun ; Yoshimori, Tamotsu ; Hurley, James H.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (29), p.17003-17010
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An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
Author / Creator:Ye, Yansheng ; Tyndall, Erin R. ; Bui, Van ; Tang, Zhenyuan ; Shen, Yan ; Jiang, Xuejun ; Flanagan, John M. ; Wang, Hong-Gang ; Tian, Fang
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-01, Vol.12 (1), p.374-374, Article 374
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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy
Author / Creator:Strong, Lisa M ; Chang, Chunmei ; Riley, Julia F ; Boecker, C Alexander ; Flower, Thomas G ; Buffalo, Cosmo Z ; Ren, Xuefeng ; Stavoe, Andrea Kh ; Holzbaur, Erika Lf ; Hurley, James H
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2021-09, Vol.10
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The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment
Author / Creator:Shi, Xiaoshan ; Chang, Chunmei ; Yokom, Adam L ; Jensen, Liv E ; Hurley, James H
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-08, Vol.9
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ArticlesPeer ReviewedFull Text
ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins
Author / Creator:Demeter, Amanda ; Romero-Mulero, Mari Carmen ; Csabai, Luca ; Ölbei, Márton ; Sudhakar, Padhmanand ; Haerty, Wilfried ; Korcsmáros, Tamás
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-07, Vol.10 (1), p.10940, Article 10940
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Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins
Author / Creator:Gerson, Julia E. ; Linton, Hunter ; Xing, Jiazheng ; Sutter, Alexandra B. ; Kakos, Fayth S. ; Ryou, Jaimie ; Liggans, Nyjerus ; Sharkey, Lisa M. ; Safren, Nathaniel ; Paulson, Henry L. ; Ivanova, Magdalena I.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-01, Vol.11 (1), p.287-13, Article 287
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Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids
Author / Creator:Talaia, Gabriel ; Amick, Joseph ; Ferguson, Shawn M.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (8), p.1-8
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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation
Author / Creator:Li, Yi-Tong ; Yi, Cong ; Chen, Chen-Chen ; Lan, Huan ; Pan, Man ; Zhang, Shao-Jin ; Huang, Yi-Chao ; Guan, Chao-Jian ; Li, Yi-Ming ; Yu, Li ; Liu, Lei
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-03, Vol.8 (1), p.14846-14846, Article 14846
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ArticlesPeer ReviewedFull Text
Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system
Author / Creator:Pang, Yu ; Yamamoto, Hayashi ; Sakamoto, Hirokazu ; Oku, Masahide ; Mutungi, Joe Kimanthi ; Sahani, Mayurbhai Himatbhai ; Kurikawa, Yoshitaka ; Kita, Kiyoshi ; Noda, Nobuo N. ; Sakai, Yasuyoshi ; Jia, Honglin ; Mizushima, Noboru
Publisher:New York: Nature Publishing Group US
Journal title:Nature structural & molecular biology, 2019-04, Vol.26 (4), p.289-296
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Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion

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Phase separation organizes the site of autophagosome formation

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Structure, lipid scrambling activity and role in autophagosome formation of ATG9A

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Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex

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Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation

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WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy

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Oxidation of Atg3 and Atg7 mediates inhibition of autophagy

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Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

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Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

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Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I

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Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD

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Structural basis for autophagy inhibition by the human Rubicon–Rab7 complex

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An N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy

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Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy

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The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

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ULK1 and ULK2 are less redundant than previously thought: computational analysis uncovers distinct regulation and functions of these autophagy induction proteins

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Shared and divergent phase separation and aggregation properties of brain-expressed ubiquilins

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Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

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A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation

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Evolution from covalent conjugation to non-covalent interaction in the ubiquitin-like ATG12 system

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