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ArticlesPeer ReviewedFull Text
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
Author / Creator:Szendroedi, Julia ; Yoshimura, Toru ; Phielix, Esther ; Koliaki, Chrysi ; Marcucci, Mellissa ; Zhang, Dongyan ; Jelenik, Tomas ; Müller, Janette ; Herder, Christian ; Nowotny, Peter ; Shulman, Gerald I. ; Roden, Michael
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2014-07, Vol.111 (26), p.9597-9602
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Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
Author / Creator:Benoit, Stephen C ; Kemp, Christopher J ; Elias, Carol F ; Abplanalp, William ; Herman, James P ; Migrenne, Stephanie ; Lefevre, Anne-Laure ; Cruciani-Guglielmacci, Céline ; Magnan, Christophe ; Yu, Fang ; Niswender, Kevin ; Irani, Boman G ; Holland, William L ; Clegg, Deborah J
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2009-09, Vol.119 (9), p.2577-2589
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Targeting PKCθ Promotes Satellite Cell Self-Renewal
Author / Creator:Benedetti, Anna ; Fiore, Piera Filomena ; Madaro, Luca ; Lozanoska-Ochser, Biliana ; Bouché, Marina
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-03, Vol.21 (7), p.2419
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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes
Author / Creator:Sun, Zuoming ; Arendt, Christopher W. ; Ellmeier, Wilfried ; Schaeffer, Edward M. ; Sunshine, Mary Jean ; Gandhi, Leena ; Annes, Justin ; Petrzilka, Daniela ; Kupfer, Abraham ; Schwartzberg, Pamela L. ; Littman, Dan R.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2000-03, Vol.404 (6776), p.402-407
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PKC-[theta] goes nuclear
Author / Creator:Visan, Ioana
Publisher:Nature Publishing Group
Journal title:Nature immunology, 2011-05, Vol.12 (5), p.386
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The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells
Author / Creator:Chuang, Huai-Chia ; Lan, Joung-Liang ; Chen, Der-Yuan ; Yang, Chia-Yu ; Chen, Yi-Ming ; Li, Ju-Pi ; Huang, Ching-Yu ; Liu, Pao-En ; Wang, Xiaohong ; Tan, Tse-Hua
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2011-11, Vol.12 (11), p.1113-1118
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Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ
Author / Creator:Camerino, Giulia Maria ; Bouchè, Marina ; De Bellis, Michela ; Cannone, Maria ; Liantonio, Antonella ; Musaraj, Kejla ; Romano, Rossella ; Smeriglio, Piera ; Madaro, Luca ; Giustino, Arcangela ; De Luca, Annamaria ; Desaphy, Jean-François ; Camerino, Diana Conte ; Pierno, Sabata
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Pflügers Archiv, 2014-12, Vol.466 (12), p.2215-2228
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PKC-theta knockout mice are protected from fat-induced insulin resistance
Author / Creator:Kim, Jason K ; Fillmore, Jonathan J ; Sunshine, Mary Jean ; Albrecht, Bjoern ; Higashimori, Takamasa ; Kim, Dong-Wook ; Liu, Zhen-Xiang ; Soos, Timothy J ; Cline, Gary W ; O'Brien, William R ; Littman, Dan R ; Shulman, Gerald I
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2004-09, Vol.114 (6), p.823-827
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TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation
Author / Creator:Wang, Xu-Dong ; Gong, Yu ; Chen, Zhi-Long ; Gong, Bei-Ni ; Xie, Ji-Ji ; Zhong, Chuan-Qi ; Wang, Qi-Long ; Diao, Liang-Hui ; Xu, Anlong ; Han, Jiahuai ; Altman, Amnon ; Li, Yingqiu
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2015-11, Vol.16 (11), p.1195-1203
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Ameliorated ConA-induced hepatitis in the absence of PKC-theta
Author / Creator:Fang, Xianfeng ; Wang, Ruiqing ; Ma, Jian ; Ding, Yan ; Shang, Weirong ; Sun, Zuoming
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e31174
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A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28
Author / Creator:Kong, Kok-Fai ; Yokosuka, Tadashi ; Canonigo-Balancio, Ann J ; Isakov, Noah ; Saito, Takashi ; Altman, Amnon
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2011-11, Vol.12 (11), p.1105-1112
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PKC theta ablation improves healing in a mouse model of muscular dystrophy
Author / Creator:Madaro, Luca ; Pelle, Andrea ; Nicoletti, Carmine ; Crupi, Annunziata ; Marrocco, Valeria ; Bossi, Gianluca ; Soddu, Silvia ; Bouché, Marina
Publisher:United States: Public Library of Science
Journal title:PloS one, 2012-02, Vol.7 (2), p.e31515-e31515
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Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury
Author / Creator:Fiore, Piera Filomena ; Benedetti, Anna ; Sandonà, Martina ; Madaro, Luca ; De Bardi, Marco ; Saccone, Valentina ; Puri, Pier Lorenzo ; Gargioli, Cesare ; Lozanoska-Ochser, Biliana ; Bouché, Marina
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2020-01, Vol.21 (3), p.932
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Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy
Author / Creator:Morroni, Jacopo ; Schirone, Leonardo ; Valenti, Valentina ; Zwergel, Clemens ; Riera, Carles Sánchez ; Valente, Sergio ; Vecchio, Daniele ; Schiavon, Sonia ; Ragno, Rino ; Mai, Antonello ; Sciarretta, Sebastiano ; Lozanoska-Ochser, Biliana ; Bouchè, Marina
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-02, Vol.23 (4), p.2256
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TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation
Author / Creator:Wang, Xu-dong ; Gong, Yu ; Chen, Zhi-long ; Gong, Bei-ni ; Xie, Ji-ji ; Zhong, Chuan-qi ; Wang, Qi-long ; Diao, Liang-hui ; Xu, Anlong ; Han, Jiahuai ; Altman, Amnon ; Li, Yingqiu
Publisher:New York: Nature Publishing Group
Journal title:Nature immunology, 2015-11, Vol.16 (11), p.1195-1203
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eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1
Author / Creator:García-Ortiz, Almudena ; Martín-Cofreces, Noa B ; Ibiza, Sales ; Ortega, Ángel ; Izquierdo-Álvarez, Alicia ; Trullo, Antonio ; Victor, Víctor M ; Calvo, Enrique ; Sot, Begoña ; Martínez-Ruiz, Antonio ; Vázquez, Jesús ; Sánchez-Madrid, Francisco ; Serrador, Juan M
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2017-04, Vol.15 (4), p.e2000653
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Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation
Author / Creator:Bi, Kun ; Tanaka, Yoshihiko ; Coudronniere, Nolwenn ; Sugie, Katsuji ; Hong, Sooji ; van Stipdonk, Marianne J. B. ; Altman, Amnon
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2001-06, Vol.2 (6), p.556-563
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T-cell receptor signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-[theta]-mediated phosphorylation of RanGAP1
Author / Creator:He, Yujiao ; Yang, Zhiguo ; Zhao, Chen-si ; Xiao, Zhihui ; Gong, Yu ; Li, Yun-Yi ; Chen, Yiqi ; Du, Yunting ; Feng, Dianying ; Altman, Amnon ; Li, Yingqiu
Publisher:eLife Science Publications, Ltd
Journal title:eLife, 2021-06, Vol.10
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PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization
Author / Creator:Kumar, Raj ; Mani, Arul M. ; Singh, Nikhlesh K. ; Rao, Gadiparthi N.
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-05, Vol.11 (5), p.325, Article 325
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T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1
Author / Creator:He, Yujiao ; Yang, Zhiguo ; Zhao, Chen-si ; Xiao, Zhihui ; Gong, Yu ; Li, Yun-Yi ; Chen, Yiqi ; Du, Yunting ; Feng, Dianying ; Altman, Amnon ; Li, Yingqiu
Publisher:Cambridge: eLife Sciences Publications Ltd
Journal title:eLife, 2021-06, Vol.10
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Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

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Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents

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Targeting PKCθ Promotes Satellite Cell Self-Renewal

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

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PKC-[theta] goes nuclear

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The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells

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Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ

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PKC-theta knockout mice are protected from fat-induced insulin resistance

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TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation

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Ameliorated ConA-induced hepatitis in the absence of PKC-theta

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A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

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PKC theta ablation improves healing in a mouse model of muscular dystrophy

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Lack of PKCθ Promotes Regenerative Ability of Muscle Stem Cells in Chronic Muscle Injury

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Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy

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TCR-induced sumoylation of the kinase PKC-[theta] controls T cell synapse organization and T cell activation

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eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

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Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

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T-cell receptor signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-[theta]-mediated phosphorylation of RanGAP1

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PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization

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T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

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