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408 results for Granzymes+-+metabolism

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ArticlesPeer ReviewedFull Text
How regulatory T cells work
Author / Creator:Vignali, Dario A. A. ; Collison, Lauren W. ; Workman, Creg J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Immunology, 2008-07, Vol.8 (7), p.523-532
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Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Author / Creator:Goodridge, Jodie P. ; Jacobs, Benedikt ; Saetersmoen, Michelle L. ; Clement, Dennis ; Hammer, Quirin ; Clancy, Trevor ; Skarpen, Ellen ; Brech, Andreas ; Landskron, Johannes ; Grimm, Christian ; Pfefferle, Aline ; Meza-Zepeda, Leonardo ; Lorenz, Susanne ; Wiiger, Merete Thune ; Louch, William E. ; Ask, Eivind Heggernes ; Liu, Lisa L. ; Oei, Vincent Yi Sheng ; Kjällquist, Una ; Linnarsson, Sten ; Patel, Sandip ; Taskén, Kjetil ; Stenmark, Harald ; Malmberg, Karl-Johan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-01, Vol.10 (1), p.514-514, Article 514
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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells
Author / Creator:Kurachi, Makoto ; Barnitz, R Anthony ; Yosef, Nir ; Odorizzi, Pamela M ; DiIorio, Michael A ; Lemieux, Madeleine E ; Yates, Kathleen ; Godec, Jernej ; Klatt, Martin G ; Regev, Aviv ; Wherry, E John ; Haining, W Nicholas
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2014-04, Vol.15 (4), p.373-383
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Gasdermin E suppresses tumour growth by activating anti-tumour immunity
Author / Creator:Zhang, Zhibin ; Zhang, Ying ; Xia, Shiyu ; Kong, Qing ; Li, Shunying ; Liu, Xing ; Junqueira, Caroline ; Meza-Sosa, Karla F. ; Mok, Temy Mo Yin ; Ansara, James ; Sengupta, Satyaki ; Yao, Yandan ; Wu, Hao ; Lieberman, Judy
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2020-03, Vol.579 (7799), p.415-420
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Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells
Author / Creator:Benmebarek, Mohamed-Reda ; Karches, Clara Helke ; Cadilha, Bruno Loureiro ; Lesch, Stefanie ; Endres, Stefan ; Kobold, Sebastian
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-03, Vol.20 (6), p.1283
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Spatial predictors of immunotherapy response in triple-negative breast cancer
Author / Creator:Wang, Xiao Qian ; Danenberg, Esther ; Huang, Chiun-Sheng ; Egle, Daniel ; Callari, Maurizio ; Bermejo, Begoña ; Dugo, Matteo ; Zamagni, Claudio ; Thill, Marc ; Anton, Anton ; Zambelli, Stefania ; Russo, Stefania ; Ciruelos, Eva Maria ; Greil, Richard ; Győrffy, Balázs ; Semiglazov, Vladimir ; Colleoni, Marco ; Kelly, Catherine M. ; Mariani, Gabriella ; Del Mastro, Lucia ; Biasi, Olivia ; Seitz, Robert S. ; Valagussa, Pinuccia ; Viale, Giuseppe ; Gianni, Luca ; Bianchini, Giampaolo ; Ali, H. Raza
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-09, Vol.621 (7980), p.868-876
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Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity
Author / Creator:Hay, Zachary L. Z. ; Slansky, Jill E.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2022-02, Vol.23 (3), p.1833
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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity
Author / Creator:Zhang, Yuan ; Li, Na ; Suh, Heikyung ; Irvine, Darrell J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-01, Vol.9 (1), p.6-6, Article 6
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Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling
Author / Creator:Santos-Zas, Icia ; Lemarié, Jeremie ; Zlatanova, Ivana ; Cachanado, Marine ; Seghezzi, Jean-Christophe ; Benamer, Hakim ; Goube, Pascal ; Vandestienne, Marie ; Cohen, Raphael ; Ezzo, Maya ; Duval, Vincent ; Zhang, Yujiao ; Su, Jin-Bo ; Bizé, Alain ; Sambin, Lucien ; Bonnin, Philippe ; Branchereau, Maxime ; Heymes, Christophe ; Tanchot, Corinne ; Vilar, José ; Delacroix, Clement ; Hulot, Jean-Sebastien ; Cochain, Clement ; Bruneval, Patrick ; Danchin, Nicolas ; Tedgui, Alain ; Mallat, Ziad ; Simon, Tabassome ; Ghaleh, Bijan ; Silvestre, Jean-Sébastien ; Ait-Oufella, Hafid
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1483-13, Article 1483
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Improved visualization of protein consensus sequences by iceLogo
Author / Creator:Colaert, Niklaas ; Helsens, Kenny ; Martens, Lennart ; Vandekerckhove, Joël ; Gevaert, Kris
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2009-11, Vol.6 (11), p.786-787
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Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity
Author / Creator:Wang, Mitchell S. ; Hu, Yuesong ; Sanchez, Elisa E. ; Xie, Xihe ; Roy, Nathan H. ; de Jesus, Miguel ; Winer, Benjamin Y. ; Zale, Elizabeth A. ; Jin, Weiyang ; Sachar, Chirag ; Lee, Joanne H. ; Hong, Yeonsun ; Kim, Minsoo ; Kam, Lance C. ; Salaita, Khalid ; Huse, Morgan
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-06, Vol.13 (1), p.3222-15, Article 3222
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ArticlesPeer ReviewedFull Text
Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells
Author / Creator:Oltra, Sara S. ; Colomo, Sara ; Sin, Laura ; Pérez-López, María ; Lázaro, Sara ; Molina-Crespo, Angela ; Choi, Kyoung-Han ; Ros-Pardo, David ; Martínez, Lidia ; Morales, Saleta ; González-Paramos, Cristina ; Orantes, Alba ; Soriano, Mario ; Hernández, Alberto ; Lluch, Ana ; Rojo, Federico ; Albanell, Joan ; Gómez-Puertas, Paulino ; Ko, Jae-Kyun ; Sarrió, David ; Moreno-Bueno, Gema
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2023-05, Vol.30 (5), p.1366-1381
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ArticlesPeer ReviewedFull Text
Cytotoxic CD8⁺ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons
Author / Creator:Coque, Emmanuelle ; Salsac, Céline ; Espinosa-Carrasco, Gabriel ; Varga, Béla ; Degauque, Nicolas ; Cadoux, Marion ; Crabé, Roxane ; Virenque, Anaïs ; Soulard, Claire ; Fierle, Julie K. ; Brodovitch, Alexandre ; Libralato, Margot ; Végh, Attila G. ; Venteo, Stéphanie ; Scamps, Frédérique ; Boucraut, José ; Laplaud, David ; Hernandez, Javier ; Gergely, Csilla ; Vincent, Thierry ; Raoul, Cédric
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-02, Vol.116 (6), p.2312-2317
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CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
Author / Creator:Ahrends, Tomasz ; Busselaar, Julia ; Severson, Tesa M. ; Bąbała, Nikolina ; de Vries, Evert ; Bovens, Astrid ; Wessels, Lodewyk ; van Leeuwen, Fred ; Borst, Jannie
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-12, Vol.10 (1), p.5531-13, Article 5531
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The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells
Author / Creator:Wang, Yufeng ; Zhang, Yibo ; Yi, Ping ; Dong, Wenjuan ; Nalin, Ansel P. ; Zhang, Jianying ; Zhu, Zheng ; Chen, Lichao ; Benson, Don M. ; Mundy-Bosse, Bethany L. ; Freud, Aharon G. ; Caligiuri, Michael A. ; Yu, Jianhua
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2019-01, Vol.20 (1), p.10-17
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IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection
Author / Creator:Younes, Souheil-Antoine ; Freeman, Michael L. ; Mudd, Joseph C. ; Shive, Carey L. ; Reynaldi, Arnold ; Panigrahi, Soumya ; Estes, Jacob D. ; Deleage, Claire ; Lucero, Carissa ; Anderson, Jodi ; Schacker, Timothy W. ; Davenport, Miles P. ; McCune, Joseph M. ; Hunt, Peter W. ; Lee, Sulggi A. ; Serrano-Villar, Sergio ; Debernardo, Robert L. ; Jacobson, Jeffrey M. ; Canaday, David H. ; Sekaly, Rafick-Pierre ; Rodriguez, Benigno ; Sieg, Scott F. ; Lederman, Michael M.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-07, Vol.126 (7), p.2745-2756
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MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets
Author / Creator:Kurioka, A ; Ussher, J E ; Cosgrove, C ; Clough, C ; Fergusson, J R ; Smith, K ; Kang, Y-H ; Walker, L J ; Hansen, T H ; Willberg, C B ; Klenerman, P
Publisher:New York: Nature Publishing Group US
Journal title:Mucosal immunology, 2015-03, Vol.8 (2), p.429-440
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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy
Author / Creator:Abbas, Hussein A. ; Hao, Dapeng ; Tomczak, Katarzyna ; Barrodia, Praveen ; Im, Jin Seon ; Reville, Patrick K. ; Alaniz, Zoe ; Wang, Wei ; Wang, Ruiping ; Wang, Feng ; Al-Atrash, Gheath ; Takahashi, Koichi ; Ning, Jing ; Ding, Maomao ; Beird, Hannah C. ; Mathews, Jairo T. ; Little, Latasha ; Zhang, Jianhua ; Basu, Sreyashi ; Konopleva, Marina ; Marques-Piubelli, Mario L. ; Solis, Luisa M. ; Parra, Edwin Roger ; Lu, Wei ; Tamegnon, Auriole ; Garcia-Manero, Guillermo ; Green, Michael R. ; Sharma, Padmanee ; Allison, James P. ; Kornblau, Steven M. ; Rai, Kunal ; Wang, Linghua ; Daver, Naval ; Futreal, Andrew
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-10, Vol.12 (1), p.6071-13, Article 6071
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Blockade of A₂A receptors potently suppresses the metastasis of CD73⁺ tumors
Author / Creator:Beavis, Paul A ; Divisekera, Upulie ; Paget, Christophe ; Chow, Melvyn T ; John, Liza B ; Devaud, Christel ; Dwyer, Karen ; Stagg, John ; Smyth, Mark J ; Darcy, Phillip K
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2013-09, Vol.110 (36), p.14711-14716
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Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy
Author / Creator:De Biasi, Sara ; Gibellini, Lara ; Lo Tartaro, Domenico ; Puccio, Simone ; Rabacchi, Claudio ; Mazza, Emilia M. C. ; Brummelman, Jolanda ; Williams, Brandon ; Kaihara, Kelly ; Forcato, Mattia ; Bicciato, Silvio ; Pinti, Marcello ; Depenni, Roberta ; Sabbatini, Roberto ; Longo, Caterina ; Dominici, Massimo ; Pellacani, Giovanni ; Lugli, Enrico ; Cossarizza, Andrea
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-03, Vol.12 (1), p.1669-11, Article 1669
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How regulatory T cells work

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Remodeling of secretory lysosomes during education tunes functional potential in NK cells

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The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells

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Gasdermin E suppresses tumour growth by activating anti-tumour immunity

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Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

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Spatial predictors of immunotherapy response in triple-negative breast cancer

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Granzymes: The Molecular Executors of Immune-Mediated Cytotoxicity

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Nanoparticle anchoring targets immune agonists to tumors enabling anti-cancer immunity without systemic toxicity

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Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

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Improved visualization of protein consensus sequences by iceLogo

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Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity

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Distinct GSDMB protein isoforms and protease cleavage processes differentially control pyroptotic cell death and mitochondrial damage in cancer cells

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Cytotoxic CD8⁺ T lymphocytes expressing ALS-causing SOD1 mutant selectively trigger death of spinal motoneurons

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CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities

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The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells

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IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection

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MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets

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Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy

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Blockade of A₂A receptors potently suppresses the metastasis of CD73⁺ tumors

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Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy

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