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187 results for Kupffer+Cells+-+drug+effects

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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Author / Creator:Malehmir, Mohsen ; Pfister, Dominik ; Gallage, Suchira ; Szydlowska, Marta ; Inverso, Donato ; Kotsiliti, Elena ; Leone, Valentina ; Peiseler, Moritz ; Surewaard, Bas G. J. ; Rath, Dominik ; Ali, Adnan ; Wolf, Monika Julia ; Drescher, Hannah ; Healy, Marc E. ; Dauch, Daniel ; Kroy, Daniela ; Krenkel, Oliver ; Kohlhepp, Marlene ; Engleitner, Thomas ; Olkus, Alexander ; Sijmonsma, Tjeerd ; Volz, Julia ; Deppermann, Carsten ; Stegner, David ; Helbling, Patrick ; Nombela-Arrieta, César ; Rafiei, Anahita ; Hinterleitner, Martina ; Rall, Marcel ; Baku, Florian ; Borst, Oliver ; Wilson, Caroline L. ; Leslie, Jack ; O’Connor, Tracy ; Weston, Christopher J. ; Chauhan, Abhishek ; Adams, David H. ; Sheriff, Lozan ; Teijeiro, Ana ; Prinz, Marco ; Bogeska, Ruzhica ; Anstee, Natasha ; Bongers, Malte N. ; Notohamiprodjo, Mike ; Geisler, Tobias ; Withers, Dominic J. ; Ware, Jerry ; Mann, Derek A. ; Augustin, Hellmut G. ; Vegiopoulos, Alexandros ; Milsom, Michael D. ; Rose, Adam J. ; Lalor, Patricia F. ; Llovet, Josep M. ; Pinyol, Roser ; Tacke, Frank ; Rad, Roland ; Matter, Matthias ; Djouder, Nabil ; Kubes, Paul ; Knolle, Percy A. ; Unger, Kristian ; Zender, Lars ; Nieswandt, Bernhard ; Gawaz, Meinrad ; Weber, Achim ; Heikenwalder, Mathias
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-04, Vol.25 (4), p.641-655
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Acute liver failure is regulated by MYC- and microbiome-dependent programs
Author / Creator:Kolodziejczyk, Aleksandra A. ; Federici, Sara ; Zmora, Niv ; Mohapatra, Gayatree ; Dori-Bachash, Mally ; Hornstein, Shanni ; Leshem, Avner ; Reuveni, Debby ; Zigmond, Ehud ; Tobar, Ana ; Salame, Tomer Meir ; Harmelin, Alon ; Shlomai, Amir ; Shapiro, Hagit ; Amit, Ido ; Elinav, Eran
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2020-12, Vol.26 (12), p.1899-1911
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Multi-cell type human liver microtissues for hepatotoxicity testing
Author / Creator:Messner, S. ; Agarkova, I. ; Moritz, W. ; Kelm, J. M.
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Archives of toxicology, 2013-01, Vol.87 (1), p.209-213
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A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery
Author / Creator:Wolfram, Joy ; Nizzero, Sara ; Liu, Haoran ; Li, Feng ; Zhang, Guodong ; Li, Zheng ; Shen, Haifa ; Blanco, Elvin ; Ferrari, Mauro
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-10, Vol.7 (1), p.13738-13, Article 13738
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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
Author / Creator:Lanaya, Hanane ; Natarajan, Anuradha ; Komposch, Karin ; Li, Liang ; Amberg, Nicole ; Chen, Lei ; Wculek, Stefanie K. ; Hammer, Martina ; Zenz, Rainer ; Peck-Radosavljevic, Markus ; Sieghart, Wolfgang ; Trauner, Michael ; Wang, Hongyang ; Sibilia, Maria
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2014-10, Vol.16 (10), p.972-981
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FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis
Author / Creator:Verbeke, Len ; Mannaerts, Inge ; Schierwagen, Robert ; Govaere, Olivier ; Klein, Sabine ; Vander Elst, Ingrid ; Windmolders, Petra ; Farre, Ricard ; Wenes, Mathias ; Mazzone, Massimiliano ; Nevens, Frederik ; van Grunsven, Leo A. ; Trebicka, Jonel ; Laleman, Wim
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-09, Vol.6 (1), p.33453, Article 33453
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Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis
Author / Creator:Norona, Leah M. ; Nguyen, Deborah G. ; Gerber, David A. ; Presnell, Sharon C. ; Mosedale, Merrie ; Watkins, Paul B.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2019-01, Vol.14 (1), p.e0208958-e0208958
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Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
Author / Creator:Huang, Wan ; Metlakunta, Anantha ; Dedousis, Nikolaos ; Zhang, Pili ; Sipula, Ian ; Dube, John J. ; Scott, Donald K. ; O'Doherty, Robert M.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2010-02, Vol.59 (2), p.347-357
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Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin
Author / Creator:Jiang, Kuan ; Tian, Kaisong ; Yu, Yifei ; Wu, Ercan ; Yang, Min ; Pan, Feng ; Qian, Jun ; Zhan, Changyou
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-07, Vol.15 (1), p.6136-13, Article 6136
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TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
Author / Creator:Armando Andres Roca Suarez ; Plissonnier, Marie-Laure ; Grand, Xavier ; Michelet, Maud ; Giraud, Guillaume ; Saez-Palma, Maria ; Dubois, Anaëlle ; Heintz, Sarah ; Diederichs, Audrey ; Nicolaas Van Renne ; Vanwolleghem, Thomas ; Daffis, Stephane ; Li, Li ; Kolhatkar, Nikita ; Yao-Chun, Hsu ; Wallin, Jeffrey J ; Lau, Audrey H ; Fletcher, Simon P ; Rivoire, Michel ; Levrero, Massimo ; Testoni, Barbara ; Zoulim, Fabien
Publisher:London: BMJ Publishing Group LTD
Journal title:Gut, 2024-12, p.gutjnl-2023-331396
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Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis
Author / Creator:Baeza-Raja, Bernat ; Goodyear, Andrew ; Liu, Xiao ; Lam, Kevin ; Yamamoto, Lynn ; Li, Yingwu ; Dodson, G. Steven ; Takeuchi, Toshi ; Kisseleva, Tatiana ; Brenner, David A. ; Dabbagh, Karim
Publisher:United States: Public Library of Science
Journal title:PloS one, 2020-06, Vol.15 (6), p.e0234038
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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection
Author / Creator:Sivangala Thandi, Ramya ; Radhakrishnan, Rajesh Kumar ; Tripathi, Deepak ; Paidipally, Padmaja ; Azad, Abul K ; Schlesinger, Larry S ; Samten, Buka ; Mulik, Sachin ; Vankayalapati, Ramakrishna
Publisher:England: Nature Publishing Group
Journal title:Nature communications, 2020-07, Vol.11 (1), p.3535-3535
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Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner
Author / Creator:Meier, Raphael P. H. ; Meyer, Jeremy ; Montanari, Elisa ; Lacotte, Stephanie ; Balaphas, Alexandre ; Muller, Yannick D. ; Clément, Sophie ; Negro, Francesco ; Toso, Christian ; Morel, Philippe ; Buhler, Leo H.
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-03, Vol.20 (6), p.1295
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A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates
Author / Creator:Ströbel, Simon ; Kostadinova, Radina ; Fiaschetti-Egli, Katia ; Rupp, Jana ; Bieri, Manuela ; Pawlowska, Agnieszka ; Busler, Donna ; Hofstetter, Thomas ; Sanchez, Katarzyna ; Grepper, Sue ; Thoma, Eva
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2021-11, Vol.11 (1), p.22765-18, Article 22765
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Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models
Author / Creator:Nono, Justin Komguep ; Fu, Kai ; Mpotje, Thabo ; Varrone, Georgianna ; Aziz, Nada Abdel ; Mosala, Paballo ; Hlaka, Lerato ; Kamdem, Severin Donald ; Xu, Daigen ; Spangenberg, Thomas ; Brombacher, Frank
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-06, Vol.10 (1), p.10638-10638, Article 10638
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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist
Author / Creator:Iwaisako, Keiko ; Haimerl, Michael ; Paik, Yong-Han ; Taura, Kojiro ; Kodama, Yuzo ; Sirlin, Claude ; Yu, Elizabeth ; Yu, Ruth T ; Downes, Michael ; Evans, Ronald M ; Brenner, David A ; Schnabl, Bernd
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (21), p.E1369-E1376
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Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate Cells
Author / Creator:Araújo Júnior, Raimundo Fernandes de ; Garcia, Vinícius Barreto ; Leitão, Renata Ferreira de Carvalho ; Brito, Gerly Anne de Castro ; Miguel, Emilio de Castro ; Guedes, Paulo Marcos Matta ; de Araújo, Aurigena Antunes
Publisher:United States: Public Library of Science
Journal title:PloS one, 2016-02, Vol.11 (2), p.e0148868-e0148868
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The role of heme in sepsis induced Kupffer cell PANoptosis and senescence
Author / Creator:Li, Tingting ; Adams, Joseph ; Zhu, Peilin ; Zhang, Tao ; Tu, Fei ; Gravitte, Amy ; Zhang, Xiaojin ; Liu, Li ; Casteel, Jared ; Yakubenko, Valentin ; Williams, David L. ; Li, Chuanfu ; Wang, Xiaohui
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2025-04, Vol.16 (1), p.284-14, Article 284
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Targeted Sodium Acetate Liposomes for Hepatocytes and Kupffer Cells: An Oral Dual-Targeted Therapeutic Approach for Non-Alcoholic Fatty Liver Disease Alleviation
Author / Creator:Hou, Yichao ; Gao, Xilong ; Gong, Jiahui ; Dong, Xinrui ; Hao, Yanling ; Zhai, Zhengyuan ; Zhang, Hao ; Zhang, Ming ; Liu, Rong ; Wang, Ran ; Zhao, Liang
Publisher:Switzerland: MDPI AG
Journal title:Nutrients, 2025-03, Vol.17 (5), p.930
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Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high‐fat diet
Author / Creator:Miura, Kouichi ; Ohnishi, Hirohide ; Morimoto, Naoki ; Minami, Shinichiro ; Ishioka, Mitsuaki ; Watanabe, Shunji ; Tsukui, Mamiko ; Takaoka, Yoshinari ; Nomoto, Hiroaki ; Isoda, Norio ; Yamamoto, Hironori
Publisher:England: John Wiley & Sons, Inc
Journal title:Cancer science, 2019-02, Vol.110 (2), p.771-783
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Showing 1 to 20 of 187 results

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Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

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Acute liver failure is regulated by MYC- and microbiome-dependent programs

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Multi-cell type human liver microtissues for hepatotoxicity testing

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A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery

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EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation

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FXR agonist obeticholic acid reduces hepatic inflammation and fibrosis in a rat model of toxic cirrhosis

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Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

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Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

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Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin

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TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism

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Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis

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Ornithine-A urea cycle metabolite enhances autophagy and controls Mycobacterium tuberculosis infection

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Interleukin-1 Receptor Antagonist Modulates Liver Inflammation and Fibrosis in Mice in a Model-Dependent Manner

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A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidates

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Investigating the antifibrotic effect of the antiparasitic drug Praziquantel in in vitro and in vivo preclinical models

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Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist

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Carvedilol Improves Inflammatory Response, Oxidative Stress and Fibrosis in the Alcohol-Induced Liver Injury in Rats by Regulating Kuppfer Cells and Hepatic Stellate Cells

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The role of heme in sepsis induced Kupffer cell PANoptosis and senescence

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Targeted Sodium Acetate Liposomes for Hepatocytes and Kupffer Cells: An Oral Dual-Targeted Therapeutic Approach for Non-Alcoholic Fatty Liver Disease Alleviation

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Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high‐fat diet

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