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ArticlesPeer ReviewedFull Text
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis
Author / Creator:Orozco, S ; Yatim, N ; Werner, M R ; Tran, H ; Gunja, S Y ; Tait, S WG ; Albert, M L ; Green, D R ; Oberst, A
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2014-10, Vol.21 (10), p.1511-1521
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Targeting RIPK1 for the treatment of human diseases
Author / Creator:Degterev, Alexei ; Ofengeim, Dimitry ; Yuan, Junying
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-05, Vol.116 (20), p.9714-9722
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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Author / Creator:Mifflin, Lauren ; Ofengeim, Dimitry ; Yuan, Junying
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2020-08, Vol.19 (8), p.553-571
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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
Author / Creator:Strilic, Boris ; Yang, Lida ; Albarrán-Juárez, Julián ; Wachsmuth, Laurens ; Han, Kang ; Müller, Ulrike C. ; Pasparakis, Manolis ; Offermanns, Stefan
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-08, Vol.536 (7615), p.215-218
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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis
Author / Creator:Newton, Kim ; Dugger, Debra L. ; Wickliffe, Katherine E. ; Kapoor, Neeraj ; de Almagro, M. Cristina ; Vucic, Domagoj ; Komuves, Laszlo ; Ferrando, Ronald E. ; French, Dorothy M. ; Webster, Joshua ; Roose-Girma, Merone ; Warming, Søren ; Dixit, Vishva M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2014-03, Vol.343 (6177), p.1357-1360
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Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury
Author / Creator:Tonnus, Wulf ; Meyer, Claudia ; Steinebach, Christian ; Belavgeni, Alexia ; von Mässenhausen, Anne ; Gonzalez, Nadia Zamora ; Maremonti, Francesca ; Gembardt, Florian ; Himmerkus, Nina ; Latk, Markus ; Locke, Sophie ; Marschner, Julian ; Li, Wenjun ; Short, Spencer ; Doll, Sebastian ; Ingold, Irina ; Proneth, Bettina ; Daniel, Christoph ; Kabgani, Nazanin ; Kramann, Rafael ; Motika, Stephen ; Hergenrother, Paul J. ; Bornstein, Stefan R. ; Hugo, Christian ; Becker, Jan Ulrich ; Amann, Kerstin ; Anders, Hans-Joachim ; Kreisel, Daniel ; Pratt, Derek ; Gütschow, Michael ; Conrad, Marcus ; Linkermann, Andreas
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-07, Vol.12 (1), p.4402-14, Article 4402
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ArticlesPeer ReviewedFull Text
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
Author / Creator:Newton, K ; Dugger, D L ; Maltzman, A ; Greve, J M ; Hedehus, M ; Martin-McNulty, B ; Carano, R A D ; Cao, T C ; van Bruggen, N ; Bernstein, L ; Lee, W P ; Wu, X ; DeVoss, J ; Zhang, J ; Jeet, S ; Peng, I ; McKenzie, B S ; Roose-Girma, M ; Caplazi, P ; Diehl, L ; Webster, J D ; Vucic, D
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2016-09, Vol.23 (9), p.1565-1576
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ArticlesPeer ReviewedFull Text
When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157
Author / Creator:Rojas-Rivera, Diego ; Delvaeye, Tinneke ; Roelandt, Ria ; Nerinckx, Wim ; Augustyns, Koen ; Vandenabeele, Peter ; Bertrand, Mathieu J M
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2017-06, Vol.24 (6), p.1100-1110
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ArticlesPeer ReviewedFull Text
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Author / Creator:Patel, Snahel ; Webster, Joshua D. ; Varfolomeev, Eugene ; Kwon, Youngsu C. ; Cheng, Jason H. ; Zhang, Juan ; Dugger, Debra L. ; Wickliffe, Kate E. ; Maltzman, Allie ; Sujatha-Bhaskar, Swathi ; Bir Kohli, Pawan ; Ramaswamy, Sreema ; Deshmukh, Gauri ; Liederer, Bianca M. ; Fong, Rina ; Hamilton, Greg ; Lupardus, Patrick ; Caplazi, Patrick ; Lee, Wyne P. ; van Lookeren Campagne, Menno ; Johnson, Adam ; McKenzie, Brent S. ; Junttila, Melissa R. ; Newton, Kim ; Vucic, Domagoj
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2020-01, Vol.27 (1), p.161-175
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ArticlesPeer ReviewedFull Text
Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury
Author / Creator:Linkermann, Andreas ; Bräsen, Jan H. ; Himmerkus, Nina ; Liu, Shuya ; Huber, Tobias B. ; Kunzendorf, Ulrich ; Krautwald, Stefan
Publisher:Basingstoke: Elsevier Inc
Journal title:Kidney international, 2012-04, Vol.81 (8), p.751-761
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RIP3 mediates the embryonic lethality of caspase-8-deficient mice
Author / Creator:Kaiser, William J. ; Upton, Jason W. ; Long, Alyssa B. ; Livingston-Rosanoff, Devon ; Daley-Bauer, Lisa P. ; Hakem, Razqallah ; Caspary, Tamara ; Mocarski, Edward S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-03, Vol.471 (7338), p.368-372
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ArticlesPeer ReviewedFull Text
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Author / Creator:Dondelinger, Yves ; Delanghe, Tom ; Rojas-Rivera, Diego ; Priem, Dario ; Delvaeye, Tinneke ; Bruggeman, Inge ; Van Herreweghe, Franky ; Vandenabeele, Peter ; Bertrand, Mathieu J. M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2017-10, Vol.19 (10), p.1237-1247
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The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873
Author / Creator:Wang, K ; Liu, F ; Liu, C-Y ; An, T ; Zhang, J ; Zhou, L-Y ; Wang, M ; Dong, Y-H ; Li, N ; Gao, J-N ; Zhao, Y-F ; Li, P-F
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2016-08, Vol.23 (8), p.1394-1405
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ArticlesPeer ReviewedFull Text
Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium
Author / Creator:Robinson, Nirmal ; McComb, Scott ; Mulligan, Rebecca ; Dudani, Renu ; Krishnan, Lakshmi ; Sad, Subash
Publisher:New York: Nature Publishing Group US
Journal title:Nature immunology, 2012-10, Vol.13 (10), p.954-962
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ArticlesPeer ReviewedFull Text
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation
Author / Creator:Xu, Gang ; Li, Ying ; Zhang, Shengyuan ; Peng, Haoran ; Wang, Yunyun ; Li, Dekang ; Jin, Taijie ; He, Zhuohao ; Tong, Yilun ; Qi, Chunting ; Wu, Guowei ; Dong, Kangyun ; Gou, Jizhou ; Liu, Yang ; Xiao, Tongyang ; Qu, Jing ; Li, Liang ; Liu, Liang ; Zhao, Ping ; Zhang, Zheng ; Yuan, Junying
Publisher:Singapore: Springer Singapore
Journal title:Cell research, 2021-12, Vol.31 (12), p.1230-1243
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ArticlesPeer ReviewedFull Text
Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation
Author / Creator:Duan, Xiaoru ; Liu, Xinxin ; Liu, Nian ; Huang, Yuqiong ; Jin, Zilin ; Zhang, Song ; Ming, Zhangyin ; Chen, Hongxiang
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2020-02, Vol.11 (2), p.134, Article 134
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RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)
Author / Creator:Liu, Yuping ; Liu, Ting ; Lei, Tiantian ; Zhang, Dingding ; Du, Suya ; Girani, Lea ; Qi, Dandan ; Lin, Chen ; Tong, Rongsheng ; Wang, Yi
Publisher:Athens: Spandidos Publications
Journal title:International journal of molecular medicine, 2019-09, Vol.44 (3), p.771-786
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ArticlesPeer ReviewedFull Text
Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
Author / Creator:Kist, Matthias ; Kőműves, László G. ; Goncharov, Tatiana ; Dugger, Debra L. ; Yu, Charles ; Roose-Girma, Merone ; Newton, Kim ; Webster, Joshua D. ; Vucic, Domagoj
Publisher:London: Nature Publishing Group UK
Journal title:Cell death and differentiation, 2021-03, Vol.28 (3), p.985-1000
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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
Author / Creator:Welz, Patrick-Simon ; Wullaert, Andy ; Vlantis, Katerina ; Kondylis, Vangelis ; Fernández-Majada, Vanesa ; Ermolaeva, Maria ; Kirsch, Petra ; Sterner-Kock, Anja ; van Loo, Geert ; Pasparakis, Manolis
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2011-09, Vol.477 (7364), p.330-334
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Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models
Author / Creator:Takahashi, N ; Duprez, L ; Grootjans, S ; Cauwels, A ; Nerinckx, W ; DuHadaway, J B ; Goossens, V ; Roelandt, R ; Van Hauwermeiren, F ; Libert, C ; Declercq, W ; Callewaert, N ; Prendergast, G C ; Degterev, A ; Yuan, J ; Vandenabeele, P
Publisher:London: Nature Publishing Group UK
Journal title:Cell death & disease, 2012-11, Vol.3 (11), p.e437-e437
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RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis

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Targeting RIPK1 for the treatment of human diseases

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Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target

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Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis

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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

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Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury

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RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

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When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

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Rip1 (Receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury

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RIP3 mediates the embryonic lethality of caspase-8-deficient mice

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MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death

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The long noncoding RNA NRF regulates programmed necrosis and myocardial injury during ischemia and reperfusion by targeting miR-873

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Type I interferon induces necroptosis in macrophages during infection with Salmonella enterica serovar Typhimurium

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SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

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Inhibition of keratinocyte necroptosis mediated by RIPK1/RIPK3/MLKL provides a protective effect against psoriatic inflammation

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RIP1/RIP3-regulated necroptosis as a target for multifaceted disease therapy (Review)

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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

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FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation

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Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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